Sonodynamic therapy of cancer. A comprehensive experimental study

Николаев, А. Л.; Гопин, А. В.; Bozhevol’nov, V. E.; Mazina, Svetlana E.; Северин, А. В.; Рудин, В. Н.; Andronova, N. A.; Treschalina, Helen M.; Kaliya, O. L.; Solovyeva, L. I.; Luk'yanets, E. A.

doi:10.1007/s11172-014-0546-2

Cited by 13 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent developments in the field of sonosensitizers have led to a renewed interest in applications of SDT. In recent years, various nanoparticles (NPs) have been used to develop sonosensitizers for SDT, including ones assembled from organic molecules and inorganic NPs such as MnTTP‐HSA NPs, TiO 2 , Si‐based nanomaterials, and gold (Au) NPs . Recently developed new sonosensitizers include black‐titanium NPs and black‐phosphorus‐based sonosensitizers, which prompted us to make a new classification and discussion .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

View full text Add to dashboard Cite

Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Jüngste Entwicklungen im Gebiet der Sonosensibilisatoren haben zu einem wiedererstarkten Interesse an Anwendungen von SDT geführt. In den letzten Jahren wurden diverse Nanopartikel (NPs) verwendet, um Sonosensibilisatoren für die SDT zu entwickeln, darunter solche, die aus organischen Molekülen und anorganischen NPs wie MnTTP‐HSA‐NPs, TiO 2 , Si‐basierten Nanomaterialien und Gold‐NPs zusammengesetzt waren . Kürzlich entwickelte neue Sonosensibilisatoren umfassen schwarze Titan‐NPs und schwarze Phosphor‐basierte Sonosensibilisatoren, was uns zu einer neuen Klassifizierung und Diskussion veranlasste .…”

Section: Introductionunclassified

Ultraschallaktivierte Sensibilisatoren

et al. 2020

View full text Add to dashboard Cite

Durch Licht ausgelöste Verfahren in der Krebstherapie sind üblicherweise durch ihre geringe Penetrationstiefe limitiert. Die Sonotheranostika, insbesondere die sonodynamische Therapie (SDT), die sich von der photodynamischen Therapie (PDT) unterscheidet und hoch penetrierende Schallwellen zur Aktivierung einer Klasse von schallresponsiven Materialien verwendet, die als Sonosensibilisatoren bezeichnet werden, hat in den letzten Jahren an erheblichem Interesse gewonnen. Der Effekt der SDT hängt eng mit den strukturellen und physikochemischen Eigenschaften der Sonosensibilisatoren zusammen, was die Entwicklung von neuen schallaktivierbaren Materialien als Sonosensibilisatoren für diverse biomedizinische Anwendungen erforderlich gemacht hat. Dieser Aufsatz enthält eine Zusammenfassung und Diskussion der neuartigen Typen von Sonosensibilisatoren, die in den letzten Jahren entwickelt wurden. Anwendungen von Sonosensibilisatoren mit vielfältigen Funktionen wie Bildgebung, Wirkstofftransport und die Kombination mit anderen Behandlungsmethoden sollten neue Strategien für die Krankheitstherapie zur Verfügung stellen.

show abstract

“…The sonosensitizers play a significant role in SDT. From early organic molecules such as various types of porphyrin derivatives to current inorganic nanoparticles have been developed to sonosensitizers 24 , including ones assembled from organic molecules and inorganic nanoparticles such as MnTTP-HSA NPs 25 , Si-based nanomaterials 26 , and blackphosphorus-based sonosensitizers 27 . However, organic sonosensitizers often exhibit limited stability under US irradiation [28][29][30] , and some of complicated nanoparticles show low ROS thus quantum yield decreasing SDT efficiency 31 .…”

mentioning

confidence: 99%

A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

et al. 2021

View full text Add to dashboard Cite

As a basic structure of most polypyridinal metal complexes, [Ru(bpy)3]2+, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)3]2+ has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)3]2+ is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)3]2+ can produce singlet oxygen (1O2) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimulation in cancer cells. Furthermore, [Ru(bpy)3]2+ enables effective destruction of mice tumors, and the therapeutic effect can reach deep tissues over 10 cm under US irradiation. This work paves a way for polypyridinal metal complexes to be applied to the noninvasive precise sonotherapy of cancer.

show abstract

Sonodynamic therapy of cancer. A comprehensive experimental study

Cited by 13 publications

References 15 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

Ultraschallaktivierte Sensibilisatoren

A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

Contact Info

Product

Resources

About