2023
DOI: 10.1007/s00339-022-06377-0
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Sonodynamic therapy of pancreatic cancer cells based on synergistic chemotherapeutic effects of selenium-PEG-curcumin nanoparticles and gemcitabine

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Cited by 5 publications
(4 citation statements)
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“…Macrophages incubated with curcumin and exposed to ultrasound irradiation experience an interaction between activated curcumin and molecular oxygen, producing cytotoxic ROS, especially singlet oxygen, which ultimately leads to cell death [42,[52][53][54][55]. Wang F. et al investigated the sonodynamic effect of curcumin on THP-1-derived macrophages using slightly different parameters than our study [17].…”
Section: Discussionmentioning
confidence: 85%
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“…Macrophages incubated with curcumin and exposed to ultrasound irradiation experience an interaction between activated curcumin and molecular oxygen, producing cytotoxic ROS, especially singlet oxygen, which ultimately leads to cell death [42,[52][53][54][55]. Wang F. et al investigated the sonodynamic effect of curcumin on THP-1-derived macrophages using slightly different parameters than our study [17].…”
Section: Discussionmentioning
confidence: 85%
“…The combined effect of these factors can facilitate curcumin delivery, significantly enhancing its effectiveness while minimizing side effects [40,41]. Several reports indicate the dual role of curcumin-based nanoparticles in photothermal (PTT) and SDT therapies [24,42].…”
Section: Introductionmentioning
confidence: 99%
“…However, accumulation under physiological conditions and elimination from circulation lead to formation of less ROS and ultimately decreased therapeutic efficacy [10] , [12] . Nowadays, the emergence of nanotechnology has led to the development of nanoparticles (NPs)-based acoustic sensitizers [13] , [14] , [15] , [16] , [17] , [18] . It has been demonstrated that the presence of NPs amplifies the cavitation effects and improves their efficiency by lowering the cavitation threshold [13] , [14] .…”
Section: Introductionmentioning
confidence: 99%
“…Targeted, photothermal, photodynamic, sonodynamic, radiation-chemo, and stem cell therapy are among the new routes of cancer treatment. Nanomedicine has introduced novel treatment approaches and represented solutions for challenges in cancer medicine [2][3][4][5][6][7][8][9].…”
mentioning
confidence: 99%