Sonodynamic Therapy on Intracranial Glioblastoma Xenografts Using Sinoporphyrin Sodium Delivered by Ultrasound with Microbubbles

Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Section: Biomedical Applications Of Sonosensitizersmentioning

confidence: 90%

“…In addition, Pi et al. have also reported DVDMS‐mediated SDT against intracranial glioblastoma xenografts (Figure D) . DVDMS accumulated at the tumor sites upon US‐induced BBB opening and produced microbubbles, which effectively cleared the glioma in an intracellular concentration‐dependent manner.…”

Section: Biomedical Applications Of Sonosensitizersmentioning

confidence: 99%

Ultrasound‐Activated Sensitizers and Applications

et al. 2020

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“…The PET images were performed before (at the 13th day) and after three MHT applications (at the 22nd day), as depicted in Figure 10, using a small animal equipment Triumph ® II preclinical scanner (Gamma Medica-Ideas, Nortridge, CA, USA). 18 F-FDG (38)(39)(40) was injected in the penile vein and after 45 min, the animal was posionited with the brain in the center of the field of view. Image was acquired for 30 min and reconstructed using OSEM 3D algoritm, 20 interactions, and 4 subgroups.…”

Section: Evaluation Of Mht Therapeutic Effect By 18 F-fdg-petmentioning

confidence: 99%

“…The imaging techniques most used are: bioluminescence (BLI) [40][41][42][43], near-infrared fluorescence (NIRF) [44], magnetic resonance imaging (MRI) [45,46], positron emission tomography (PET) [47][48][49], single photon emission computed tomography (SPECT) [50], magnetic particle imaging (MPI) [51], computed tomography (CT) [52], and behavioral assessment [53,54], which also has been indicate as tools for functional preclinical evaluations of longitudinal processes [40][41][42][43][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

“…The bioluminescence technique has shown to be an excellent tool due to the best cost-effectivity for therapeutic outcomes evaluation in glioblastoma model [40][41][42][43], by having the advantage of high sensitivity with low background [55][56][57]. This technique involves the luciferin application to in vitro or in vivo models; luceferin reacts with luciferase enzyme, contained only in implanted tumor cells, this reaction is dependent of factors such as Mg 2+ , adenosinetriphosphate (ATP) and oxygen.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Efficiency of Multiple Applications of Magnetic Hyperthermia Technique in Glioblastoma Using Aminosilane Coated Iron Oxide Nanoparticles: In Vitro and In Vivo Study

Rego

Nucci

Mamani

et al. 2020

IJMS

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Magnetic hyperthermia (MHT) has been shown as a promising alternative therapy for glioblastoma (GBM) treatment. This study consists of three parts: The first part evaluates the heating potential of aminosilane-coated superparamagnetic iron oxide nanoparticles (SPIONa). The second and third parts comprise the evaluation of MHT multiple applications in GBM model, either in vitro or in vivo. The obtained heating curves of SPIONa (100 nm, +20 mV) and their specific absorption rates (SAR) stablished the best therapeutic conditions for frequencies (309 kHz and 557 kHz) and magnetic field (300 Gauss), which were stablished based on three in vitro MHT application in C6 GBM cell line. The bioluminescence (BLI) signal decayed in all applications and parameters tested and 309 kHz with 300 Gauss have shown to provide the best therapeutic effect. These parameters were also established for three MHT applications in vivo, in which the decay of BLI signal correlates with reduced tumor and also with decreased tumor glucose uptake assessed by positron emission tomography (PET) images. The behavior assessment showed a slight improvement after each MHT therapy, but after three applications the motor function displayed a relevant and progressive improvement until the latest evaluation. Thus, MHT multiple applications allowed an almost total regression of the GBM tumor in vivo. However, futher evaluations after the therapy acute phase are necessary to follow the evolution or tumor total regression. BLI, positron emission tomography (PET), and spontaneous locomotion evaluation techniques were effective in longitudinally monitoring the therapeutic effects of the MHT technique.

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Intelligent Sonocatalytic Nanoagents for Energy Conversion‐Based Therapies

Feng,

Xiang,

Huang

et al. 2023

Adv Funct Materials

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Sonodynamic therapy (SDT) utilizes ultrasound‐irradiating sonosensitizers to convert ultrasonic vibrations into chemical energy and produce reactive oxygen species (ROS) that cause cell apoptosis or necrosis. SDT demonstrates significant potential in the treatment of deep tumors without normal tissue damage. Rapid advances in the efficacy of SDT have enabled the rational design and construction of novel intelligent sonocatalytic nanoagents (SCNs) with various functions for versatile biomedical applications. Herein, the most recent critical advancements in intelligent SCNs for energy conversion‐based therapies are discussed. Typical SCNs including organic molecules, organic micro‐/nanoparticles, inorganic micro‐/nanoparticles, organic/inorganic hybrids, and piezoelectric materials are introduced and summarized in detail. Furthermore, these intelligent SCNs are designed for different energy conversion‐based therapies such as SDT, SDT‐assisted chemotherapy, SDT‐assisted photodynamic therapy, SDT‐assisted photothermal therapy, SDT‐assisted gas therapy, SDT‐assisted sonoporation from the cell membrane to the blood brain barrier, and high‐intensity focused ultrasound‐based sonothermal therapy. It is believed that this review will provide an overview of the application of intelligent SCNs in sonodynamic therapies to better understand the limitations and challenges of these SCNs and further promote their advancements for a broad range of biomedical applications.

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Sonodynamic Therapy on Intracranial Glioblastoma Xenografts Using Sinoporphyrin Sodium Delivered by Ultrasound with Microbubbles

Cited by 42 publications

References 29 publications

Ultrasound‐Activated Sensitizers and Applications

Ultrasound‐Activated Sensitizers and Applications

Therapeutic Efficiency of Multiple Applications of Magnetic Hyperthermia Technique in Glioblastoma Using Aminosilane Coated Iron Oxide Nanoparticles: In Vitro and In Vivo Study

Intelligent Sonocatalytic Nanoagents for Energy Conversion‐Based Therapies

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