Sonodynamic therapy reduces iron retention of hemorrhagic plaque

Li, Bicheng; Gong, Jie; Sheng, Siqi; Lu, Minqiao; Guo, Shuyuan; Yao, Jianting; Zhang, Haiyu; Zhao, Xingjuan; Cao, Zhengyu; Sun, Xin; Wang, Huan; Cao, Yang; Jiang, Yongxing; Tian, Zhen; Liu, Bin; Zhao, Hua; Zhang, Zhiguo; Jin, Hong; Tian, Ye

doi:10.1002/btm2.10193

Cited by 13 publications

(13 citation statements)

References 35 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sonodynamic therapy (SDT) has gained widespread attention recently due to its safety, deep tissue penetration depth, and cost-effectiveness. [244,245] SDT, as a burgeoning therapeutic modality, enables US irradiation to trigger sonosensitizers to generate ROS for CVD therapy. [246,247] For example, Li et al designed US-propelled Janus rod (JR)-shaped micromotors (Pc/Ca@r-JRs) for US-driven thrombus penetration and SDT of thrombosis without using any thrombolytic agents (Figure 18A).…”

Section: Ultrasound-based Therapymentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Wei

Jiang

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels the development of advanced technologies for CVD diagnosis and treatment. Biomarker-responsive nanomaterials are appealing therapeutic platforms that provide new horizons for CVD theranostics. In this review, recent advances in nanomaterials with endogenous biomarkers as stimuli or targets for CVD theranostics is presented. First, the categories of biomarkers involved are comprehensively itemized based on pathological mechanisms including pH, reactive oxygen species, lipids, enzymes, macrophage receptors, subendothelium components, platelet receptors, inflammation, and osteopontin. The role of these biomarkers in bridge-building between nanomaterials and CVD is then presented. Next, the biomedical applications of nanomaterials responsive to endogenous biomarkers as stimuli or targets for the diagnosis and treatment of CVD are elaborated. Finally, the challenges and future research directions of biomarker-responsive nanomaterials in CVD are also discussed. This review will provide scientific guidance to facilitate clinical applications of biomarker-responsive nanomaterials.

show abstract

Section: Ultrasound-based Therapymentioning

confidence: 99%

“…Sonodynamic therapy (SDT) has gained widespread attention recently due to its safety, deep tissue penetration depth, and cost‐effectiveness. [ 244,245 ] SDT, as a burgeoning therapeutic modality, enables US irradiation to trigger sonosensitizers to generate ROS for CVD therapy. [ 246,247 ] For example, Li et al.…”

Section: Cvd Therapymentioning

confidence: 99%

Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Wei

Jiang

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…by activating the ROS-Nrf2-PFN1 signaling pathway and promoted transferrin efflux, which reduced iron retention in plaques and especially in the macrophages. [237] Another representative sonosensitizer is a natural extract represented by hydroxysafflor yellow and curcumin. The former induced THP-1 macrophage autophagy and cleared local inflammation in plaque by inhibiting PI3K/Akt/mTOR induction under US irradiation.…”

Section: Sonodynamic Therapy (Sdt)mentioning

confidence: 99%

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

Cheng,

Huang,

Chen

et al. 2023

Advanced Science

View full text Add to dashboard Cite

With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and the associated diseases have emerged as the leading cause of death. Due to their fascinating physical, chemical, and biological characteristics, nanomaterials are regarded as a promising tool to tackle enormous challenges in medicine. The emerging discipline of nanomedicine has filled a huge application gap in the atherosclerotic field, ushering a new generation of diagnosis and treatment strategies. Herein, based on the essential pathogenic contributors of atherogenesis, as well as the distinct composition/structural characteristics, synthesis strategies, and surface design of nanoplatforms, the three major application branches (nanodiagnosis, nanotherapy, and nanotheranostic) of nanomedicine in atherosclerosis are elaborated. Then, state‐of‐art studies containing a sequence of representative and significant achievements are summarized in detail with an emphasis on the intrinsic interaction/relationship between nanomedicines and atherosclerosis. Particularly, attention is paid to the biosafety of nanomedicines, which aims to pave the way for future clinical translation of this burgeoning field. Finally, this comprehensive review is concluded by proposing unresolved key scientific issues and sharing the vision and expectation for the future, fully elucidating the closed loop from atherogenesis to the application paradigm of nanomedicines for advancing the early achievement of clinical applications.

show abstract

“…In recent years, SDT has been elucidated to show the therapeutic effect on atherosclerosis [58][59][60][61][62][63][64]. Studies have shown the SDT-induced foam-cell apoptosis, iron retention alleviation and cytokine secretion inhibition contributed to the stabilization in advanced plaques by using 5aminolevulinic acid, sinoporphyrin sodium, etc [59,61]. Advanced progress has been achieved in clinical trials [65].…”

Section: Othersmentioning

confidence: 99%

Emerging diagnostic and therapeutic technologies based on ultrasound-triggered biomaterials

et al. 2023

View full text Add to dashboard Cite

Ultrasound (US) is a kind of acoustic waves with frequency higher than 20 kHz. Learning from the echo detection ability of bats and dolphins, scientists applied US for clinical imaging by sending out US waves and detecting echo with shifted intensities and frequencies from human tissue. US has long been played a critical role in noninvasive, real-time, low cost and portable diagnostic imaging. With the in-depth study of US in multidisciplinary fields, US and US-responsive materials has shown practical value in not only disease diagnosis, but also disease treatment. In this review, we introduce the lately proposed and representative US-responsive materials for biomedical applications, including diagnostic and therapeutic applications. We focused on US-mediated physiochemical therapies, such as sonodynamic therapy, high-intensity focused US ablation, sonothermal therapy, thrombolysis, etc., and US-controlled delivery of chemotherapeutics, gas, gene, protein, and bacteria. We also conclude the current challenges facing the clinical translation of the smart US-responsive materials and prospect future development of US medicine.

show abstract

Sonodynamic therapy reduces iron retention of hemorrhagic plaque

Cited by 13 publications

References 35 publications

Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

Emerging diagnostic and therapeutic technologies based on ultrasound-triggered biomaterials

Contact Info

Product

Resources

About