Sonographic appearance of gestational trophoblastic disease evolving into epithelioid trophoblastic tumor

Okumura, M.; Fushida, Koji; Rezende, Waldemir Washington; Schultz, R. T.; Zugaib, Marcelo

doi:10.1002/uog.7560

Cited by 22 publications

(18 citation statements)

References 12 publications

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“…Four cases among five previous reports exhibited cystic components within lesions on radiological images . The ETT in our case did not show cystic components within the lesion on CT and MR images.…”

Section: Discussionsupporting

confidence: 47%

“…Four cases among five previous reports exhibited cystic components within lesions on radiological images. 4,[6][7][8][9] The ETT in our case did not show cystic components within the lesion on CT and MR images. Kageyama et al reported that the cystic component contained massive amounts of necrotic tissue and hemorrhagic materials, and no cystic wall was present.…”

Section: Figuresupporting

confidence: 41%

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Epithelioid trophoblastic tumor of the uterus: A case report with radiologic–pathologic correlation

Ohya

Higuchi

Shimojo

et al. 2017

J of Obstet and Gynaecol

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Herein, we report a rare case of an epithelioid trophoblastic tumor of the uterus with radiologic-pathologic correlation in a 56-year-old postmenopausal woman. On T2-weighted magnetic resonance (MR) imaging, the tumor appeared as a hypointense irregular mass compared with the surrounding myometrium of the uterine corpus and encircled the cavity of the lower uterine segment. On dynamic contrast-enhanced MR images, the tumor appeared as a hypovascular mass and an inhomogeneously hyperintense mass in the delayed phase. In addition, non-contrast computed tomography images showed some spotty areas of very high density within the tumor. These radiologic findings were well correlated with the histological features, such as abundant hyalinization and calcification within the tumor. Accurate interpretation of MR and computed tomography findings was helpful to differentiate epithelioid trophoblastic tumor from other gestational trophoblastic diseases and uterine carcinomas.

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Section: Discussionsupporting

confidence: 47%

Section: Figuresupporting

confidence: 41%

Epithelioid trophoblastic tumor of the uterus: A case report with radiologic–pathologic correlation

Ohya

Higuchi

Shimojo

et al. 2017

J of Obstet and Gynaecol

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“…Radiologically, these tumors are well-circumscribed. Doppler ultrasound has demonstrated an increase in blood flow [2,19,20]. …”

Section: Discussionmentioning

confidence: 99%

Epithelioid Trophoblastic Tumor: Report of Two Cases in Postmenopausal Women with Literature Review and Emphasis on Cytological Findings

Almarzooqi

Al-Safi²,

Al-Jassar³

et al. 2014

Acta Cytologica

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Background: Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm of intermediate trophoblasts. It was first described by Shih and Kurman [Am J Surg Pathol 1998;22:1393-1403] who outlined its clinicopathologic characteristics in 14 cases, establishing it as a distinct entity of gestational trophoblastic tumors. It represents 1.39% of all gestational trophoblastic diseases. Most cases are reported in reproductive-age women following a prior gestation with a time interval between 2 weeks and 30 years. ETT is extremely rare in postmenopausal women. It is commonly misdiagnosed as a squamous cell carcinoma (SCC), poorly differentiated carcinoma or another gestational trophoblastic tumor. Limited data is available regarding its cytological features on Pap smears. Cases: We report 2 cases of uterine ETT occurring in postmenopausal women. In both cases, an initial diagnosis of an SCC and a poorly differentiated carcinoma was rendered. We highlight the features of ETT helpful in differentiating it from other mimickers with emphasis on rarely reported cytological features of this neoplasm. Conclusion: ETT is a rare tumor with characteristic cytological features, but is commonly confused with SCC. A high index of suspicion is needed to make the correct diagnosis or to raise the consideration of ETT, especially in cases with an increased β-human chorionic gonadotropin.

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“…• Epithelioid trophoblastic tumor appear early in the course of disease with irregular echolucent lacunae within the myometrium on transvaginal ultrasound, but later in the disease with a well-circumscribed solitary echogenic lesion in the fundal myometrium without blood fl ow [ 50 ]. …”

Section: Ultrasound In the Diagnosis And Management Of Gtnmentioning

confidence: 98%

First-Trimester Ultrasound in Gestational Trophoblastic Disease

Esselen

Goldstein

Horowitz

et al. 2016

First-Trimester Ultrasound

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Sonographic appearance of gestational trophoblastic disease evolving into epithelioid trophoblastic tumor

Abstract: ABSTRACT

Cited by 22 publications

References 12 publications

Epithelioid trophoblastic tumor of the uterus: A case report with radiologic–pathologic correlation

Epithelioid trophoblastic tumor of the uterus: A case report with radiologic–pathologic correlation

Epithelioid Trophoblastic Tumor: Report of Two Cases in Postmenopausal Women with Literature Review and Emphasis on Cytological Findings

First-Trimester Ultrasound in Gestational Trophoblastic Disease

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