Sonographic appearance of subungual squamous cell carcinoma in the hand

Quintana-Codina, Monica; Creus-Vila, L.; Iglesias-Plaza, Ana; Iglesias‐Sancho, Maribel; Melé‐Ninot, Gemma; Lázaro-Simó, Anna Isabel; Salleras-Redonnet, Montse

doi:10.1002/jcu.22506

Cited by 9 publications

(5 citation statements)

References 9 publications

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“…53,54 Plain films have low sensitivity and specificity for detecting bone invasion, and although ultrasound may be helpful in differentiating subungual tumors, it has not been studied as a tool to assess nSCC invasion. 38,49,50 Histopathologic analysis, whether through bone biopsy or modified MMS, remains necessary to confirm bone invasion of nSCC. Once confirmed, a multidisciplinary approach to amputation using MMS for primary tumor excision combined with subsequent amputation may maximize digit preservation and function but requires further study.…”

Section: Discussionmentioning

confidence: 99%

“…46 However, there is currently no standard protocol for imaging of nSCC to detect bone involvement, and routine imaging before treatment has not been shown to influence choice of treatment. [47][48][49][50] On radiographic imaging, nSCC involving the bone cannot be distinguished from other causes of bone marrow edema, including subungual keratoacanthoma. 51,52 Subungual keratoacanthoma can cause resorption of underlying bone and appear lytic on imaging but is pathologically distinct from nSCC.…”

Section: Discussionmentioning

confidence: 99%

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Treatment Options and Outcomes for Squamous Cell Carcinoma of the Nail Unit: A Systematic Review

et al. 2021

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BACKGROUND Nail squamous cell carcinoma (nSCC) is the most common nail unit malignancy. However, no studies to date have evaluated treatment options for nSCC based on recurrence data while controlling for invasion. OBJECTIVE To identify temporal trends in nSCC treatment modalities and compare treatment outcomes based on invasion. METHODS AND MATERIALSThe authors performed a systematic review of articles published on PubMed, MEDLINE, and Scopus from inception to April 2020 reporting treatment of nSCC. The primary outcome was disease recurrence. RESULTS Reports of nSCC treatments have increased in the past decade. Mohs micrographic surgery (MMS) is the most common treatment reported overall. The lowest recurrence rates for in situ nSCC were seen with wide surgical excision (WSE) and MMS. For invasive disease, the recurrence rates were lowest with amputation, MMS, and WSE. CONCLUSION Complete surgical excision of nSCC with either WSE or MMS is associated with lower recurrence rates than limited excision and nonsurgical therapies, regardless of degree of invasion. The prognostic significance of in situ versus invasive disease remains unclear. Confirmation of complete excision may improve outcomes. Digital amputation is indicated for nSCC with bone invasion. Prospective studies and randomized controlled trials are needed to directly compare surgical modalities for nSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treatment Options and Outcomes for Squamous Cell Carcinoma of the Nail Unit: A Systematic Review

et al. 2021

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“…the most common feature being that of a highly vascular, heterogeneously hypoechoic, mass with irregular margins. [21][22][23] The key points that emerged in this study are discussed below. (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound features of the subungual glomus tumor and squamous cell carcinomas

Sechi

Alessandrini

Patrizi

et al. 2020

Skin Research and Technology

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The nail is a complex skin appendage which plays a key role not only in tactile sensitivity and proprioception but also in picking up and handling small objects by exerting a counterpressure against the fingertip. The nail plate, commonly called the nail, originates from the nail matrix, a cul-de-sac highly proliferative structure lying below the proximal nail fold. The nail plate covers and protects the nail bed, which consists of a superficial epidermal layer and deeper dermis. Due to the lack of subcutaneous tissue, the nail bed is closely attached to the underlying periosteum of the distal phalanx. The area between the nail plate and the bony margin

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“…Scientific evidence to date on US and subungual tumors is very scarce, mostly as isolated clinical cases describing the ultrasonographic features of tumors, such as subungual schwannoma [417], keratoacanthoma [418], and squamous cell carcinoma [419].…”

Section: Nail Tumorsmentioning

confidence: 99%

The EFSUMB Guidelines and Recommendations for Musculoskeletal Ultrasound – Part I: Extraarticular Pathologies

et al. 2021

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The first part of the guidelines and recommendations for musculoskeletal ultrasound, produced under the auspices of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB), provides information about the use of musculoskeletal ultrasound for assessing extraarticular structures (muscles, tendons, entheses, ligaments, bones, bursae, fasciae, nerves, skin, subcutaneous tissues, and nails) and their pathologies. Clinical applications, practical points, limitations, and artifacts are described and discussed for every structure. After an extensive literature review, the recommendations have been developed according to the Oxford Centre for Evidence-based Medicine and GRADE criteria and the consensus level was established through a Delphi process. The document is intended to guide clinical users in their daily practice.

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Sonographic appearance of subungual squamous cell carcinoma in the hand

Cited by 9 publications

References 9 publications

Treatment Options and Outcomes for Squamous Cell Carcinoma of the Nail Unit: A Systematic Review

Treatment Options and Outcomes for Squamous Cell Carcinoma of the Nail Unit: A Systematic Review

Ultrasound features of the subungual glomus tumor and squamous cell carcinomas

The EFSUMB Guidelines and Recommendations for Musculoskeletal Ultrasound – Part I: Extraarticular Pathologies

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