Sonographic assessment of optic nerve and ophthalmic vessels in patients with idiopathic intracranial hypertension

Ebraheim, Asmaa M.; Mourad, Husam S; Kishk, Nirmeen A.; Eldin, Nashwa Badr; Saad, Abdullah A

doi:10.1080/01616412.2018.1473097

Cited by 32 publications

(42 citation statements)

References 38 publications

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“…). A total of 34 studies provided mean values for ONSD measurement . The pool of mean ONSD measurements was 4.78 mm (95% CI, 4.63‐4.94 mm; Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The interrater reliability has been shown to be very high in several studies, so that for trained examiners no relevant variability effect on the measured values should occur. In over two thirds of the evaluated studies, authors used the mean value from three subsequent measurements to reduce further the effect of intrarater variability.…”

Section: Discussionmentioning

confidence: 99%

“…This larger heterogeneity could be an expression of the inconsistent compliance with the correct definition of ONSD in some of the published studies, as some authors incorrectly include the hypoechogenic dura mater also into the measurement of the ONSD. 49 The interrater reliability has been shown to be very high in several studies, 5,18,27 so that for trained examiners no relevant variability effect on the measured values should occur. In over two thirds of the evaluated studies, authors used the mean value from three subsequent measurements to reduce further the effect of intrarater variability.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 34 studies provided mean values for ONSD measurement. 13,[15][16][17][18] The pool of mean ONSD measurements was 4.78 mm (95% CI, 4.63-4.94 mm; Fig. 4), with evidence of substantial heterogeneity between estimates ONSD (I 2 = 50.6%).…”

Section: Study Selection and Study Characteristicsmentioning

confidence: 98%

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Quantification of Optic Nerve and Sheath Diameter by Transorbital Sonography: A Systematic Review and Metanalysis

Schroeder

Katsanos

Richter

et al. 2020

Journal of Neuroimaging

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BACKGROUND AND PURPOSE To date, normal values for optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) for transorbital sonography (TOS) have only been reported by individual small‐scale studies, exposing a great variability in the measurement of the OND and ONSD. METHODS We performed a systematic review and metanalysis of available to date studies on TOS evaluation of adults without elevated intracranial pressure to provide an overview of the published literature, measuring methods and further specify normal values for OND and ONSD. RESULTS In total, we included 39 studies with 2,927 healthy volunteers (mean age 36.1 years, 44.4% female), so that a total of 5,854 eyes were examined. All pooled analyses were based on random effect models. Mean values for OND were provided in 13 studies. Calculated mean pooled OND value was 3.08 mm (95% confidence interval [CI], 2.9‐3.25), with low heterogeneity across studies (I2 = 12.7%). Thirty‐four studies provided mean values for ONSD measurement. The pool of mean ONSD measurements was 4.78 mm (95% CI, 4.63‐4.94), with evidence of substantial heterogeneity between estimates ONSD (I2 = 50.6%). There were no significant differences (P = .139) in the subsequent subgroup analysis for the different geographic continents. Also, no significant differences could be recorded for the effect of age (P = .824) or gender (P = .093). CONCLUSIONS TOS is a frequently described and widely used method. We provide reference values of OND and ONSD that are based on metanalytical analysis. Different measuring methods of ONSD result in higher heterogeneity. Subgroup analysis revealed no significant correlation between ONSD and age, gender, or geographic origin.

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“…). A total of 34 studies provided mean values for ONSD measurement . The pool of mean ONSD measurements was 4.78 mm (95% CI, 4.63‐4.94 mm; Fig.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Selection and Study Characteristicsmentioning

confidence: 98%

See 2 more Smart Citations

Quantification of Optic Nerve and Sheath Diameter by Transorbital Sonography: A Systematic Review and Metanalysis

Schroeder

Katsanos

Richter

et al. 2020

Journal of Neuroimaging

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show abstract

“…14 It should be noted that the effect of elevated ICP on the ophthalmic vessel parameters has not been established yet because of the conflicting reports in the current literature. Ebraheim et al 30 performed color Doppler ophthalmic ultrasound in 24 adult PTCS patients. However, they did not detect any significant differences in the parameters between the patient and healthy control groups.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Sheath Diameter and Retinal Artery Resistive Index Measurements with Bedside Ophthalmic Ultrasound in Pediatric Patients with Pseudotumor Cerebri Syndrome

Aslan

Yıldızdaş

Özcan

et al. 2020

J Pediatr Intensive Care

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Pseudotumor cerebri syndrome (PTCS) is characterized by raised intracranial pressure (ICP) with no neuroradiological abnormalities. Ocular ultrasound has been in use to measure optic nerve sheath diameter (ONSD), and retinal artery Doppler indices have been used for indirect assessment of ICP by pediatric intensivists. Here, we aimed to evaluate the correlation of the lumbar puncture (LP) opening pressure with the ultrasonographic ONSD and retinal resistive index (RRI) measures in patients with PTCS. And we wanted to find an answer to the following question: Can ultrasonographic ONSD measures serve as a follow-up tool in patients with PTCS? A prospective, single-center, case–control study was performed by pediatric intensive care and pediatric neurology departments. A total of 7 patients with PTCS were evaluated as patient group and 15 healthy children were evaluated as control group. The mean age of patient group was 138.8 ± 43.7 months. The mean right ONSD was 6.7 ± 0.5 mm and the mean left ONSD was 6.7 ± 0.6 mm. The mean right RRI value was 0.73 ± 0.03 and the mean left RRI was 0.73 ± 0.09. For the patient group, ONSD and RRI values of both eyes were statistically significant higher values than for the control group. The mean LP opening pressure was 56.57 ± 16.36 cmH2O. We detected strong, positive, and statistically significant correlations between the LP opening pressure and ONSD baseline measures for both the right eye (r = 0.882, p = 0.009) and the left eye (r = 0.649, p = 0.004). There was no correlation between opening pressure in LP and RRI measurements. We detected a statistically significant decrease in the right ONSD and left ONSD values and visual analog scale scores at the third-month follow-up. Our study results demonstrate that ultrasonographic ONSD measurements can be used as a noninvasive tool for assessment of the ICP at first admission and can be used as a follow-up tool in PTSC patients.

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Transcranial Doppler and Optic Nerve Ultrasonography for Non-invasive ICP Assessment

Cardim

Robba

2020

Echography and Doppler of the Brain

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Sonographic assessment of optic nerve and ophthalmic vessels in patients with idiopathic intracranial hypertension

Cited by 32 publications

References 38 publications

Quantification of Optic Nerve and Sheath Diameter by Transorbital Sonography: A Systematic Review and Metanalysis

Quantification of Optic Nerve and Sheath Diameter by Transorbital Sonography: A Systematic Review and Metanalysis

Optic Nerve Sheath Diameter and Retinal Artery Resistive Index Measurements with Bedside Ophthalmic Ultrasound in Pediatric Patients with Pseudotumor Cerebri Syndrome

Transcranial Doppler and Optic Nerve Ultrasonography for Non-invasive ICP Assessment

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