Sonographic diagnosis of thyroid metastasis from hepatocellular carcinoma

Park, Ji Yeon; Yi, Seong Yoon; Kwon, Taejung; Baek, Soo Heui; Kim, Seon-Jeong; Kwon, Ki Eon; Choi, Jiyoun

doi:10.1002/jcu.22652

Cited by 6 publications

(1 citation statement)

References 12 publications

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“…The patients were in the supine position with their necks exposed, the color Doppler ultrasonic diagnostic apparatus (model: HD15; manufacturer: PHILIPS company) was used, with the probe frequency of 10.0 MHz. First, two-dimensional ultrasound was performed to observe the position, size, morphology, internal echogenicity, etc., of the thyroid and the number, size, and morphology of intraglandular masses and at the same time closely monitor the mass for encapsulation, posterior failure, and lymphadenectasis, with particular attention paid to echogenic foci [ 11 – 13 ]. Then, the color Doppler flow imaging instrument was used to further observe the thyroid mass for internal status and peripheral blood flow change and record the relevant parameters in detail.…”

Section: Methodsmentioning

confidence: 99%

Application Value of Color Doppler Ultrasonography Combined with Thyroid Autoantibody Tests in Early Diagnosis of Thyroid Cancer

Song

Dong

Zheng

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the application value of color Doppler ultrasonography combined with thyroid autoantibody tests in the early diagnosis of thyroid cancer. Methods. The medical data of 100 patients with thyroid nodules treated in our hospital from June 2019 to June 2021 were retrospectively analyzed; all patients received color Doppler ultrasonography and thyroid autoantibody tests before surgery and were divided into the benign lesion group ( n = 45 ) and the malignant lesion group ( n = 55 ) according to the postoperative pathological findings (the gold standard), so as to compare and analyze the application value of color Doppler ultrasonography, thyroid autoantibody tests, and their combination in the early diagnosis of thyroid cancer. Results. Compared with the pathological findings, the accuracy rate, sensitivity, specificity, positive predictive value, and negative predictive value of the combined diagnosis were significantly higher than those in the single diagnosis of color Doppler ultrasonography, TgAb test, TPOAb test, and TRAb test ( P < 0.05 ), and by plotting the ROC curves to analyze the effect of these modalities in diagnosing early thyroid diseases, the results showed that the areas under the curve from large to small were combined diagnosis, color Doppler ultrasonography, TgAb test, TPOAb test, and TRAb test. Conclusion. Color Doppler ultrasonography has many advantages in the diagnosis of thyroid nodules, such as easy operation, painlessness, noninvasiveness, high efficiency, and repeatable detection, and the high-definition probe is able to show tiny lesions, echogenicity, blood flow signal, and other characteristics of foci. Combining color Doppler ultrasonography with testing thyroid autoantibodies such as TgAb, TPOAb, and TRAb can effectively improve the detection rate of early thyroid cancer, presenting significant reference value and meaning to clinical diagnosis and treatment of thyroid cancer.

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Section: Methodsmentioning

confidence: 99%

Application Value of Color Doppler Ultrasonography Combined with Thyroid Autoantibody Tests in Early Diagnosis of Thyroid Cancer

Song

Dong

Zheng

et al. 2022

Computational and Mathematical Methods in Medicine

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The efficacy of incorporating ultrasound-guided core biopsy into the clinical workflow of indeterminate thyroid tumors

Chen

Hsieh

Lee

et al. 2022

Journal of the Formosan Medical Association

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Thyroid Gland as a Metastatic Site for Hepatocellular Carcinoma: A Rare Case Report

Ge,

Jin,

Han

et al. 2024

OTT

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Background Thyroid gland metastasis from distant primary tumors is uncommon, with liver cancer being a particularly rare source. This case report describes the clinical challenges and diagnostic journey of a thyroid mass in a patient with chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma, underscoring the rarity and complexity of such metastatic relationships. Case Presentation A 63-year-old male with a long-standing history of hepatitis B-related liver cirrhosis and a recent diagnosis of hepatocellular carcinoma presented with a rapidly enlarging painful right-sided thyroid mass associated with swelling but no systemic symptoms such as fever or dysphonia. This prompted a thorough diagnostic workup. Enhanced neck scans indicated a mass potentially originating from the thyroid with tracheal compression, yet crucially, there was no evidence of lung involvement based on the chest CT. Despite the rarity of liver-to-thyroid metastasis, the patient’s multifaceted medical history warranted a broad differential diagnosis. Intervention and Outcome Surgical intervention included a right-sided thyroidectomy and partial left thyroidectomy under general anesthesia. Histopathological examination unexpectedly confirmed the presence of metastatic thyroid cancer originating from the primary liver tumor. This led to further extensive surgical management, including lymph node dissection in the central neck area. The postoperative regimen was adapted to include thyroid hormone replacement and ongoing treatment for hepatocellular carcinoma. The patient’s postoperative recovery was closely monitored, reflecting stable disease with no immediate complications. Conclusion This case highlights the clinical rarity and diagnostic challenges of liver cancer metastasizing to the thyroid. It emphasizes the need for vigilance in patients with known primary malignancies, especially hepatocellular carcinoma, presenting with new thyroid abnormalities. This advocates for a comprehensive diagnostic approach in such atypical presentations.

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Sonographic diagnosis of thyroid metastasis from hepatocellular carcinoma

Cited by 6 publications

References 12 publications

Application Value of Color Doppler Ultrasonography Combined with Thyroid Autoantibody Tests in Early Diagnosis of Thyroid Cancer

Application Value of Color Doppler Ultrasonography Combined with Thyroid Autoantibody Tests in Early Diagnosis of Thyroid Cancer

The efficacy of incorporating ultrasound-guided core biopsy into the clinical workflow of indeterminate thyroid tumors

Thyroid Gland as a Metastatic Site for Hepatocellular Carcinoma: A Rare Case Report

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