Sonographic Features of Triple-Negative and Non-Triple-Negative Breast Cancer

Wojcinski, Sebastian; Soliman, Amr A.; Schmidt, Julia; Makowski, Lars; Degenhardt, F; Hillemanns, Peter

doi:10.7863/jum.2012.31.10.1531

Cited by 72 publications

(80 citation statements)

References 35 publications

(36 reference statements)

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“…Another study (35) reported that TNBC was associated with younger age; however, in this study, we found no significant differences associated with age.…”

Section: Discussioncontrasting

confidence: 99%

Immunohistochemical Subtypes of Breast Cancer: Correlation with Clinicopathological and Radiological Factors

Sohn

Han²,

Seo

2016

Iran J Radiol

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BackgroundThe relationship between biomarkers and imaging features is important because imaging findings can predict molecular features.ObjectivesTo investigate the relationship between clinicopathologic and radiologic factors and the immunohistochemical (IHC) profiles associated with breast cancer.Patients and MethodsFrom December 2004 to September 2013, 200 patients (mean age, 56 years; range, 29 - 82 years) were diagnosed with breast cancer and underwent surgery at our institution. Their medical records were reviewed to determine age, symptom presence, mammographic findings (including mass, asymmetry, microcalcifications, or negativity), sonographic Breast Imaging-Reporting and Data System (BI-RADS) category, pathologic type of cancer (invasive ductal, mucinous, medullary, or papillary carcinoma), histologic grade, T-stage, and IHC subtypes. Based on the IHC profiles, tumor subtypes were classified as luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) enriched, or triple-negative (TN) cancers. Using univariate and multivariate logistic regression analyses, we looked for correlations between four IHC subtypes and two IHC subtypes (TN and non-triple negative [non-TN]) and clinicopathologic and radiologic factors, respectively.ResultsBased on our univariate analyses with the four subtypes, the TN subtype showed a higher incidence of masses on mammography compared to the other subtypes (P = 0.037), and the TN subtype also tended to have the highest histologic grade among the subtypes (P < 0.001). With regard to the two IHC subtypes, the TN subtype had a significant association with medullary cancer (P = 0.021), higher histologic grade (grade 3; P < 0.001), and higher T stage (T2; P = 0.027) compared to the non-TN subtypes. In a multivariate logistic regression analysis of the clinicoradiologic factors compared to luminal A, the HER2 subtype had a significant association with BI-RADS category 4b (odds ratio [OR], 9.005; 95% confidence interval [CI], 1.414 - 57.348; P = 0.020) and borderline significance with category 4c (OR, 4.669; 95% CI, 0.970 - 22.468; P = 0.055). In a multivariate logistic regression analysis of the clinicoradiologic factors associated with the non-TN subtypes, the TN subtype was significantly correlated with medullary carcinoma (OR, 7.092; 95% CI, 1.149 - 43.772; P = 0.035).ConclusionThese results suggest that patients with the TN subtypes are more likely to have higher-histologic-grade tumors and medullary cancer. The HER2 subtype was typically associated with a higher BI-RADS category.

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“…Another study (35) reported that TNBC was associated with younger age; however, in this study, we found no significant differences associated with age.…”

Section: Discussioncontrasting

confidence: 99%

Immunohistochemical Subtypes of Breast Cancer: Correlation with Clinicopathological and Radiological Factors

Sohn

Han²,

Seo

2016

Iran J Radiol

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“…Wojcinski et al described this smooth appearance as a pushing border that is associated with non-infiltrative process by rapid tumor growth. In our study, TNBC was likely to be hypoechoic mass (82.2%) or complex mass (17.8%) with microlobulated (46.7%) or circumscribed (17.8%) or indistinct (17.8%) or angular (15.6%) margin (13). Mass lesion with circumscribed margin might be misinterpreted as benign.…”

Section: Discussionmentioning

confidence: 63%

Mammographic and ultrasonographic features of triple-negative breast cancer: a comparison with other breast cancer subtypes

Kim

Choi

2013

Acta Radiol

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“…Breast cancer may simulate a benign lesion and vice versa, as there is some overlap in the sonographic features of malignant and benign tumors. Triple-negative breast cancer (TNBC), for example, exhibits significantly different features in ultrasound than non-TNBC [15]. False-positive diagnosis may result in an elevated rate of unnecessary biopsies.…”

Section: Introductionmentioning

confidence: 99%

The biology of malignant breast tumors has an impact on the presentation in ultrasound: an analysis of 315 cases

et al. 2013

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BackgroundThe aim of this study was to evaluate the relation of some ultrasound morphological parameters to biological characteristics in breast carcinoma.MethodsUltrasound data from 315 breast masses were collected. We analyzed the ultrasound features of the tumors according to the ACR BI-RADS®-US classification system stratified by hormone receptor status, HER2 status, histology grade, tumor type (ductal versus lobular), triple-negativity, breast density, tumor size, lymph node involvement and patient’s age.ResultsWe found a variety of ultrasound features that varied between the groups. Invasive lobular tumors were more likely to have an angulated margin (39% versus 22%, p = 0.040) and less likely to show posterior acoustic enhancement (3% versus 16%, p = 0.023) compared to invasive ductal carcinoma. G3 tumors were linked to a higher chance of posterior acoustic enhancement and less shadowing and the margin of G3 tumors was more often described as lobulated or microlobulated compared to G1/G2 tumors (67% versus 46%, p = 0.001). Tumors with an over-expression of HER2 exhibited a higher rate of architectural distortions in the surrounding tissue, but there were no differences regarding the other features. Hormone receptor negative tumors were more likely to exhibit a lobulated or microlobulated margin (67% versus 50%, p = 0.037) and less likely to have an echogenic halo (39% versus 64%, p = 0.001). Furthermore, the posterior acoustic feature was more often described as enhancement (33% versus 13%, p = 0.001) and less often as shadowing (20% versus 47%, p < 0.001) compared to hormone receptor positive tumors.ConclusionDepending on their biological and clinical profile, breast cancers are more or less likely to exhibit the typical criteria for malignancy in ultrasound. Moreover, certain types of breast cancer tend to possess criteria that are usually associated with benign masses. False-negative diagnosis may result in serious consequences for the patient. For the sonographer it is essential to be well aware of potential variations in the ultrasound morphology of breast tumors, as described in this paper.

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Sonographic Features of Triple-Negative and Non-Triple-Negative Breast Cancer

Cited by 72 publications

References 35 publications

Immunohistochemical Subtypes of Breast Cancer: Correlation with Clinicopathological and Radiological Factors

Immunohistochemical Subtypes of Breast Cancer: Correlation with Clinicopathological and Radiological Factors

Mammographic and ultrasonographic features of triple-negative breast cancer: a comparison with other breast cancer subtypes

The biology of malignant breast tumors has an impact on the presentation in ultrasound: an analysis of 315 cases

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