Sonographic features suggestive of amyloidosis in hemodialysis patients: Relations to serum beta2-microglobulin

Kamel, Shereen R.; Mohamed, Fatma; Darwish, Ayman F.; Kamal, Amal; Mohamed, Assmaa K.; Ali, Lamia H

doi:10.1016/j.ejr.2014.03.004

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…In pathological samples from tendon and capsular materials of individuals with dialysis-related amyloidosis, thickening in the supraspinatus tendon was proven to be a considerably significant indicator of amyloid deposition in MRI [31]. MRI observations of dialysis-related shoulder arthropathy have included thickening of the supraspinatus and subscapular tendons, aberrant liquid collection in the joint and bursa, and periarticular osseous lesions [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

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Ultrasound Versus Magnetic Resonance Imaging in the Evaluation of Shoulder Pain in End Stage Renal Disease Patients on Chronic Hemodialysis

Tharwat

Nagy

Mohsen

et al. 2022

International Journal of Clinical Practice

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Background. Musculoskeletal pain is common in hemodialysis (HD) patients and may be related to articular or periarticular amyloid deposition. The shoulder is one of the most common afflicted joints, but not all causes of shoulder pain are detectable on radiography, and magnetic resonance imaging (MRI) is not always available. The aim of this study was to evaluate the validity of musculoskeletal ultrasound (MSUS) to properly detect shoulder disorders in HD patients by identifying US abnormalities in the shoulder and comparing them to those identified on MRI, with MRI serving as the gold standard test. Methods. This cross-sectional observational study was conducted on 28 HD patients (16 males and 12 females, mean age 46.89) with either unilateral or bilateral shoulder pain. Demographic data and clinical characteristics were recruited. All patients were subjected to clinical assessment, MSUS and MRI of both shoulders. Results. US abnormalities were prevalent in almost all patients. Supraspinatus tendinopathy was the most common abnormality in symptomatic shoulders (92.1%), followed by subacromial-subdeltoid (SASD) bursitis (65.8%), humoral erosions (57.9%), and acromioclavicular joint (ACJ) osteoarthritis (52.6%). MSUS shows high sensitivity and specificity when compared to MRI in all the studied shoulder pathologies except glenohumeral joint (GHJ) effusion (sensitivity, 33.3%) and infraspinatus tendinopathy (sensitivity, 58.3%). The percentage of agreement between MSUS and MRI in detecting biceps tenosynovitis was 82.14% (kappa, 0.64), subscapularis tendinopathy 83.93% (kappa, 0.654), supraspinatus tendinopathy 91.07% (kappa, 0.617), infraspinatus tendinopathy 82.14% (kappa, 0.470), SASD bursitis 80.36% (kappa, 0.569), humeral head erosions 82.14% (kappa, 0.635), GHJ effusion 82.14% (kappa, 0.352), and ACJ osteoarthritis 76.79% (kappa, 0.539). Conclusions. Shoulder problems are common in HD patients, even in people who do not have obvious shoulder complaints. MSUS is a valuable imaging technique that assists in the diagnosis of HD patients who report shoulder pain.

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Section: Discussionmentioning

confidence: 99%

“…MRI observations of dialysis-related shoulder arthropathy have included thickening of the supraspinatus and subscapular tendons, aberrant liquid collection in the joint and bursa, and periarticular osseous lesions [ 32 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Versus Magnetic Resonance Imaging in the Evaluation of Shoulder Pain in End Stage Renal Disease Patients on Chronic Hemodialysis

Tharwat

Nagy

Mohsen

et al. 2022

International Journal of Clinical Practice

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“…In hemodialysis patients, serum β2M cannot pass through the cellulose dialysis membrane, and the accumulated β2M tends to be deposited in the musculoskeletal system, especially in the bones, ligaments, tendons, synovium and cartilage [34]. In a study of sonographic features of shoulder joints in hemodialysis patients, Kamel et al [19] demonstrated that the serum level of β2M was significantly correlated with a thickened supraspinatus tendon, tear of the supraspinatus tendon and humeral head erosion. In addition, irregularity and thickening were also found in the supraspinatus tendon in patients with amyloid accumulation on MRI [35]; this is postulated to be closely related to and interfere with the outcome of tendon repair.…”

Section: Discussionmentioning

confidence: 99%

“…In a study of musculoskeletal complications in hemodialysis patients, an occurrence rate of almost 80% for supraspinatus tendinitis was found in patients with chronic hemodialysis [16]. Furthermore, the reported incidence of rotator cuff rupture ranges from 9 to 33% among chronic hemodialysis patients [17–19]. Spontaneous major tendon rupture has been noted in patients under hemodialysis, although the exact pathomechanism remains controversial [20].…”

Section: Introductionmentioning

confidence: 99%

Inferior outcome of rotator cuff repair in chronic hemodialytic patients

Siu

et al. 2019

BMC Musculoskelet Disord

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Background Repair of rotator cuff tears has yielded excellent functional outcomes in recent decades; however, poor outcomes and dissatisfaction have been noted in specific groups. Spontaneous tendon rupture has been reported in patients receiving long-term hemodialysis owing to alteration of tendon structure, which might impede functional recovery after rotator cuff repair. The purpose of the present study was to compare the clinical outcomes between hemodialysis and non-hemodialysis patients after rotator cuff repair. Methods We retrospectively reviewed patients who underwent mini-open rotator cuff repair from Jan 2013 to Jan 2017. A total of 14 patients under chronic hemodialysis (HD) were matched to non-hemodialysis (NHD) patients at a 1:2 ratio according to age, gender, tear size, severity of fatty infiltration and history of diabetes. Pre- and post-operative functional outcome was assessed using the simple shoulder test (SST), American Shoulder and Elbow Surgeons (ASES), Shoulder Rating Scale of the University of California at Los Angeles (UCLA) and visual analog scale (VAS) scores. Clinical functional outcome at the last follow-up was adopted for comparison of the HD and NHD groups. Results A total of 42 patients were enrolled in this comparative study, with a mean age of 66.64 ± 1.68 years in the HD group and 65.71 ± 5.40 years in the NHD group. At the final clinical assessment, the post-operative functional outcome was significantly improved in both groups ( p < 0.001). However, the functional outcome of the HD group was significantly inferior to that of the NHD group in terms of the SST score (6.50 ± 2.24 vs 9.39 ± 1.87, p < 0.001), ASES score (63.17 ± 15.93 vs 86.96 ± 11.43, p < 0.001), UCLA score (20.14 ± 7.71 vs 29.82 ± 5.08, p < 0.001) and VAS score (3.00 ± 0.96 vs 1.21 ± 1.03, p < 0.001). Conclusion The improvement of pain and functional improvement of long-term hemodialysis patients were inferior to those of patients without hemodialysis after mini-open rotator cuff repair.

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Painful and painless shoulder Magnetic Resonance Imaging comparisons in hemodialysis patients and correlation with clinical findings

Türk

Fidan

Özcan

et al. 2016

BMR

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Sonographic features suggestive of amyloidosis in hemodialysis patients: Relations to serum beta2-microglobulin

Cited by 5 publications

References 28 publications

Ultrasound Versus Magnetic Resonance Imaging in the Evaluation of Shoulder Pain in End Stage Renal Disease Patients on Chronic Hemodialysis

Ultrasound Versus Magnetic Resonance Imaging in the Evaluation of Shoulder Pain in End Stage Renal Disease Patients on Chronic Hemodialysis

Inferior outcome of rotator cuff repair in chronic hemodialytic patients

Painful and painless shoulder Magnetic Resonance Imaging comparisons in hemodialysis patients and correlation with clinical findings

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