Sonographic Investigation of Transitional Cell Carcinoma of the Urinary Bladder in Small Animals

Léveillé, Renée; Biller, David S.; Partington, Beth P.; Miyabayashi, Takayoshi

doi:10.1111/j.1740-8261.1992.tb01969.x

Cited by 42 publications

(43 citation statements)

References 11 publications

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“…Blood clots usually move when the bladder is agitated. If a focal hypoechoic mass is seen, it is most likely a tumor [9]. The location of the polyps within the urinary bladder was cranioventral (n=4), cranioventral to craniodorsal (n=1), and craniodorsal (n=3) in this study.…”

Section: Discussionmentioning

confidence: 97%

“…The examination is aided by a fluidfilled urinary bladder [9]. Catheterization of the urinary bladder and injection of saline may help distend the urinary bladder but care must be taken not to simultaneously inject air bubbles, which may significantly impair ultrasonographic interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…It is important for the clinician to recognize that polypoid cystitis is an inflammatory lesion, because not all urinary masses are neoplasms and the therapy and prognosis are different for dogs with polypoid cystitis from those with bladder cancer such as transitional cell carcinoma [9]. Histopathological analysis is required for accurate diagnosis because some neoplasms can have a similar gross morphologic appearance to polypoid cystitis [3,4,8,14,15].…”

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confidence: 99%

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Diagnostic Ultrasound of Polypoid Cystitis in Dogs

Takiguchi

Inaba

2005

The Journal of Veterinary Medical Science

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ABSTRACT. Polypoid cystitis is a rare disease of the urinary bladder in dogs characterized by chronic inflammation, epithelial proliferation, and development of a polypoid mass or masses without histopathologic evidence of neoplasia. The ultrasonographic appearances of eight dogs with polypoid cystitis are described. Ultrasonography confirmed the presence of a bladder mass or masses in all patients. Ultrasonographic findings are mucosal projections and a polypoid to pedunculated mass of variable size and shape. Although a polypoid mass tends to be located in the cranioventral bladder mucosa, the polyps also could arise in the craniodorsal bladder mucosa. Ultrasonographic images are well correlated with contrast radiographic studies and gross morphological appearance. Ultrasound is a non-invasive, very useful diagnostic tool for detecting bladder polyps, but histopathology is required for definitive diagnosis.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Diagnostic Ultrasound of Polypoid Cystitis in Dogs

Takiguchi

Inaba

2005

The Journal of Veterinary Medical Science

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“…Ultrasonography also has the added benefit of improved staging of lymph nodes and abdominal organs. 37,38 Contrast cystography has the advantages of not requiring expensive ultrasound equipment and, perhaps, of having a more reproducible technique when multiple staff members are involved in the imaging on different visits. In both ultrasonography and cystography, the bladder must be fully distended for accurate assessment of the location and size of the mass.…”

Section: Other Cellular and Molecular Featuresmentioning

confidence: 99%

Canine Transitional Cell Carcinoma

Mutsaers

Widmer

Knapp

2003

Veterinary Internal Medicne

191

217

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Transitional cell carcinoma (TCC) of the urinary bladder, the most common malignancy of the urinary tract in dogs, is challenging to both diagnose and treat effectively. The prevalence of this disease may be increasing. The etiology of canine TCC is likely multifactorial. Epidemiological studies of TCC in the dog have revealed a number of risk factors, including breed and female gender, as well as environmental factors, such as insecticide exposure. This tumor is difficult to remove surgically and responds poorly to chemotherapy. The efficacy of radiotherapy and other treatment modalities needs further investigation. Cyclooxygenaseinhibiting drugs have some activity against TCC, and studies to further define these effects are ongoing. Use of the tumor/node/ metastasis (TNM) classification scheme for bladder cancer has allowed for the identification of prognostic factors. Urinary tract obstruction and metastatic disease remain challenges to treat. Work with canine TCC has demonstrated how closely this disease resembles human invasive urinary bladder cancer. Therefore, future research has the potential to benefit both dogs and humans with TCC.Key words: Animal models; Bladder cancer; Chemotherapy; Cyclooxygenase; Piroxicam; Risk factors.U rinary bladder cancer in dogs is a challenging disease to diagnose, stage, and treat. Fortunately, urinary bladder cancer is uncommon in the dog, comprising Ͻ2% of all reported canine malignancies. 1 Transitional cell carcinoma (TCC) is the most common neoplasm affecting the urinary bladder of dogs. In this article, we review current knowledge of canine TCC with regard to frequency, etiology, histopathological characteristics, cellular and molecular features, response to therapy, and prognostic factors. We also discuss why canine TCC is a good model of human invasive bladder cancer. FrequencyAlthough the true prevalence of canine TCC is not known, it is the most common form of urinary tract cancer in the dog and comprises 1.5-2% of all canine cancers. 2,3 The hospital prevalence, or proportionate morbidity, of bladder cancer at university-based veterinary hospitals appears to be increasing. 4 A search of the Veterinary Medical Data Base (VMDB) 5 from 1975 to 1995 showed a continuous increase in the prevalence of bladder cancer, with prevalence defined as the number of dogs with bladder cancer divided by the total number of individual dogs seen for any reason at the same participating university veterinary hospitals. 4 Etiology and Risk FactorsThe etiology of canine TCC is most likely multifactorial. Risk factors that have been identified include exposure to topical insecticides for flea and tick control, exposure to marshes that have been sprayed for mosquito control, obe- University, West Lafayette, IN. Reprint requests: Deborah W. Knapp, DVM, MS, DACVIM, Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907-1248; e-mail: knappdw@purdue.edu. Submitted December 28, 2001; Revised April 23, 2002; Accepted June 17, 2002. Copyright ᭧ 2003 sity, ...

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“…Entretanto, quando comparados à ultrasonografia, tais métodos demonstram consumir mais tempo, ser relativamente mais invasivos e dissipar radiação ionizante (Léveillé et al, 1992;Park e Wrigley, 2003).…”

Section: Introductionunclassified

Avaliação ultra-sonográfica e pelo Doppler colorido do carcinoma de células transicionais da bexiga em cães

Froes¹,

Iwasaki

Campos

et al. 2007

Arq. Bras. Med. Vet. Zootec.

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RESUMOEstudaram-se os aspectos ultra-sonográficos das lesões sugestivas de carcinoma de células transicionais (CCT), investigou-se a contribuição do mapeamento Doppler colorido e de amplitude no diagnóstico das lesões sugestivas de CCT e verificou-se a acurácia do método de biópsia ecodirigida por sucção traumática via sondagem uretral na coleta de material para confirmação diagnóstica CCT da bexiga. Para tal, foram selecionados nove cães que atendiam aos critérios de inclusão determinados. Destes, sete apresentavam CCT. A ultra-sonografia permitiu a detecção de massas exofílicas com características vegetantes em cinco cães, e de lesões infiltrativas na parede vesical estendendo-se para a uretra em dois. Pelo exame com Doppler colorido e de amplitude, constatou-se a vascularização interna da massa, indicativa de neoangiogênese tumoral, em quatro animais. A técnica de sucção traumática por aspiração permitiu a elucidação diagnóstica em cinco dos sete animais com CCT. Concluiu-se que, na maioria dos casos, a ultra-sonografia propicia a identificação de lesões sugestivas de CCT, constituindo a primeira técnica de diagnóstico por imagem indicada para pacientes que apresentem hematúria e disúria.Palavras-chave: cão, bexiga, ultra-sonografia, Doppler, carcinoma de células transicionais ABSTRACT

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Sonographic Investigation of Transitional Cell Carcinoma of the Urinary Bladder in Small Animals

Cited by 42 publications

References 11 publications

Diagnostic Ultrasound of Polypoid Cystitis in Dogs

Diagnostic Ultrasound of Polypoid Cystitis in Dogs

Canine Transitional Cell Carcinoma

Avaliação ultra-sonográfica e pelo Doppler colorido do carcinoma de células transicionais da bexiga em cães

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