Sonographically Measured Adipose Tissue Thickness Correlates with Laboratory Test Abnormalities Reflecting Metabolic State in Elderly Women

Urata, Tsuyoshi; Kishino, Tomonori; Watanabe, Keiko; Shibasaki, Shohei; Yotsukura, Masayuki; Mori, Hiromu; Kawamura, Naohiro; Tanaka, Toshiaki; Osaka, Maiko; Matsushima, Satsuki; Yamasaki, Satoko; Ohtsuka, Kouki; Ohnìshì, H.; Watanabe, Takashi

doi:10.1089/met.2021.0082

Cited by 1 publication

(2 citation statements)

References 17 publications

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“…It is well known that increases in WAT mass are associated with metabolic diseases including diabetes and obesity, while WAT thickness correlates positively with triacylglycerol . Activation of β3-adrenergic receptors could induce signaling cascades to enhance thermogenesis and trigger adipocyte lipolysis, initiating the sequential hydrolysis of TAGs. , In the current study, the overall abundance of TAGs in BAT is significantly lower than in WAT, and this is related to that WAT functions primarily to store energy, while BAT performs thermogenic functions.…”

Section: Discussionmentioning

confidence: 53%

“…It is well known that increases in WAT mass are associated with metabolic diseases including diabetes and obesity, 28 while WAT thickness correlates positively with triacylglycerol. 29 Activation of β3-adrenergic receptors could induce signaling cascades to enhance thermogenesis and trigger adipocyte lipolysis, initiating the sequential hydrolysis of TAGs.…”

Section: ■ Discussionmentioning

confidence: 99%

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Multiomics Approaches Identify Biomarkers for BAT Thermogenesis

Zhang,

Ma,

Wang

et al. 2023

J. Proteome Res.

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Brown adipose tissue (BAT) thermogenesis confers beneficial effects on metabolic diseases such as obesity and type-2 diabetes. Nevertheless, the mechanism and lipid driving the process that evokes this response have not been investigated yet. Here, a multiomics approach of integrative transcriptomics and lipidomics is used to explore the mechanism of regulating thermogenesis in BAT and providing promising lipid biomarkers and biomarker genes for thermogenic activators as antiobesity drugs. Lipidomics analysis demonstrated that a high abundance of glycerophospholipids and sphingolipids was more significant in BAT than in WAT. Enrichment analysis of upregulated DEGs between WAT and BAT screened suggested that the differences were mainly involved in lipid metabolism. Besides, β3-adrenergic agonist stimulation reduced the levels of TAG and DAG and increased the content of PC, PE, CL, and LPC and expression of genes involved in thermogenesis, fatty acid elongation, and glycerophospholipid metabolism in BAT. In this study, based on interpreting the inherent characterization of BAT as thermogenic tissue through comparison with WAT as fat storage tissue, adrenergic stimulation-induced BAT thermogenesis further identified specific lipid biomarkers (7 TAG species, 10 PC species, 1 LPC species, and 1 CL species) and Elovl3 and Crat gene biomarkers, which may provide targets for combating obesity by boosting BAT thermogenesis.

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