Sonography of thyroid nodules with peripheral calcifications

Park, Min-Jung; Shin, Jung Hee; Han, Boo‐Kyung; Ko, Eun Young; Hwang, Hye Sun; Kang, Seok Seon; Kim, Jung Han; Oh, Young Lyun

doi:10.1002/jcu.20584

Cited by 49 publications

(35 citation statements)

References 21 publications

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“…On the basis of retrospective US image analysis, 14 malignant nodules with an eggshell calcification had either an interrupted eggshell (10/14, 71.4%) or a thick hypoechoic outer rim (7/14, 50%), which concurs with studies that suggest that these 2 findings predict malignancy in eggshell-calcified nodules. 24,25 Nevertheless, large-scale studies are needed to correctly predict the risk of malignancy in borderline nodules because of the high possibility that the 50 nonresected borderline nodules were benign in this study.…”

Section: Discussionmentioning

confidence: 93%

“…The usefulness of hypoechogenicity, macrocalcifications, and centrally predominant vascularity as characteristics that predict malignancy for solid nodules has been debated. [2][3][4][5][6][7][8][11][12][13]24,25 Nonetheless, we used these characteristics to classify nodules as borderline malignancy. The nodules that we classified as borderline had a high incidence of malignancy (65.9%, 29/44).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound-Based Diagnostic Classification for Solid and Partially Cystic Thyroid Nodules

Kim¹,

Park²,

In³

et al. 2012

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ultrasound-Based Diagnostic Classification for Solid and Partially Cystic Thyroid Nodules

Kim¹,

Park²,

In³

et al. 2012

AJNR Am J Neuroradiol

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“…Although, microcalcifications are known to be strongly associated with malignant nodules, the association of macrocalcifications with malignancy is controversial (8)(9)(10)(11)(12)(13)(14)(15). Recent studies have revealed a relationship between macrocalcification and malignancy, particularly in papillary thyroid carcinomas (9,10,(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytopathological findings in thyroid nodules with macrocalcification: macrocalcification is not innocent as it seems

Arpacı

Özdemır

Çuhacı

et al. 2014

Arq Bras Endocrinol Metab

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Objective: Microcalcification is strongly correlated with papillary thyroid cancer. It is not clear whether macrocalcification is associated with malignancy. In this study, we aimed to assess the result of fine needle aspiration biopsies (FNAB) of thyroid nodules with macrocalcifications. Subjects and methods: We retrospectively evaluated 269 patients (907 nodules). Macrocalcifications were classified as eggshell and parenchymal macrocalcification. FNAB results were divided into four groups: benign, malignant, suspicious for malignancy, and non-diagnostic. Results: There were 79.9% female and 20.1% male and mean age was 56.9 years. Macrocalcification was detected in 46.3% nodules and 53.7% nodules had no macrocalcification. Parenchymal and eggshell macrocalcification were observed in 40.5% and 5.8% nodules, respectively. Cytologically, malignant and suspicious for malignancy rates were higher in nodules with macrocalcification compared to nodules without macrocalcification (p = 0.004 and p = 0.003, respectively). Benign and non-diagnostic cytology results were similar in two groups (p > 0.05). Nodules with eggshell calcification had higher rate of suspicious for malignancy and nodules with parenchymal macrocalcification had higher rates of malignant and suspicious for malignancy compared to those without macrocalcification (p = 0.01, p = 0.003 and p = 0.007, respectively). Conclusions: Our findings suggest that macrocalcifications are not always benign and are not associated with increased nondiagnostic FNAB results. Macrocalcification, particularly the parenchymal type should be taken into consideration. Arq Bras Endocrinol Metab. 2014;58(9):939-45 Keywords Thyroid nodule; macrocalcification; malignancy; suspicious of malignancy RESUMO Objetivo: A microcalcificação está fortemente correlacionada com o câncer papilar de tiroide. Não está claro se a macrocalcificação também está associada com malignidade. Neste estudo, nosso objetivo foi avaliar o resultado da biópsia de aspiração por agulha fina (FNAB) de nó-dulos tiroidianos com macrocalcificações. Sujeitos e métodos: Avaliamos retrospectivamente 269 pacientes (907 nódulos). As macrocalcificações foram classificadas como periféricas (casca de ovo) ou parenquimatosas (interna). Os resultados da FNAB foram divididos em quatro grupos citológicos: benignos, com malignidade, suspeita de malignidade e não diagnósticos. Resultados: Das amostras, 79,9% foram coletadas de mulheres e 20,1% de homens, e a idade média foi de 56,9 anos. A macrocalcificação foi detectada em 46,3% dos nódulos, e em 53,7% dos nódulos não havia macrocalcificação. A macrocalcificação parenquimatosa e periférica foi observada em 40,5% e 5,8% dos nódulos, respectivamente. Em termos citológicos, a malignidade e suspeita de malignidade foram mais comuns em nódulos com macrocalcificação em comparação com nódulos sem macrocalcificação (p = 0,004 e p = 0,003, respectivamente). Resultados benignos e não diagnósticos da citologia foram similares em ambos os grupos (p > 0,05). Os nódulos com calci...

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“…Polega na ocenie sprężysto-ści i ściśliwości zmian ogniskowych w tarczycy poprzez ucisk mechaniczny głowicą aparatu ultrasonograficznego na jej miąższ lub propagację impulsu fali ultradźwiękowej w miąższu. Ocena ściśliwości i sprężystości zmian ogniskowych jest odwzorowywana w postaci kolorowej skali lub w kilopaskalach [12,13].…”

Section: Zmiany Guzkowe Tarczycyunclassified

The role of the ultrasound scanning in the diagnostics of the thyroid gland of children and adolescents

Nowalska¹,

Suligowska²,

Pac-Kożuchowska³

2016

Pediatr. Endocrinol.

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Thyroid gland diseases constitute an essential part of pathologies in paediatric endocrinology. Ultrasound examination is the basic imaging method used to evaluate morphological condition of the thyroid gland. In many cases morphological changes visible in the ultrasound scan precede occurrence of clinical signs and hormonal impairments. Familiarity with typical imagesof particular thyroid gland diseases enables to surmise specific pathological disorderssolely on the basis of the ultrasound examination. Ultrasound imaging is used not only in the diagnostics but also to monitor thyroid gland diseases treatment as well as to perform thyroid gland biopsy correctly. Data from the literatureand results of authors' own research indicate the need for the development of regional standards of thyroid gland volume. In the present study we present results of research carried out worldwide by many scientists evaluating thyroid gland volume of healthy children and those indicating thyroid gland pathologies diagnosed by ultrasound scanning. Conclusions. The ultrasound examination is considered to be a gold standard in imaging diagnosis of thyroid gland, particularly in the developmental age. Pediatr. Endocrinol. 2016.15.4.57.51-58. © Copyright by PTEiDD 2016Słowa kluczowe badanie ultrasonograficzne, tarczyca, choroby dzieci StreszczenieChoroby gruczołu tarczowego stanowią dużą część patologii w endokrynologii pediatrycznej. Podstawową metodą obrazową służącą do oceny stanu morfologicznego tarczycy jest badanie ultrasonograficzne. W wielu przypadkach zmiany morfologiczne tarczycy widoczne w USG poprzedzają wystąpienie objawów klinicznych i zaburzeń hormonalnych. Znajomość obrazów charakterystycznych dla poszczególnych schorzeń tarczycy sprawia, że już na podstawie wyniku badania USG możemy sugerować konkretne jednostki chorobowe. Badanie ultrasonograficzne znajduje zastosowanie nie tylko w diagnostyce, ale i w monitorowaniu leczenia chorób tarczycy, jak rów-nież jest pomocne w prawidłowym wykonaniu biopsji gruczołu tarczowego. Dane z piśmiennictwa oraz wyniki badań własnych wskazują na konieczność opracowania norm regionalnych dla objętości tarczycy. W pracy przedstawiono wyniki badań z różnych części świata, oceniające objętość tarczycy u dzieci zdrowych oraz badania wykazujące patologie tarczycy zdiagnozowane w badaniu ultrasonograficznym. Wniosek. Badanie ultrasonograficzne stanowi złoty standard w diagnostyce obrazowej gruczołu tarczowego szczególnie w wieku rozwojowym.

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Sonography of thyroid nodules with peripheral calcifications

Abstract: Interruption and thickening of peripheral calcifications and decreased internal echogenicity of a thyroid nodule with peripheral calcifications are in favor of malignancy.

Cited by 49 publications

References 21 publications

Ultrasound-Based Diagnostic Classification for Solid and Partially Cystic Thyroid Nodules

Ultrasound-Based Diagnostic Classification for Solid and Partially Cystic Thyroid Nodules

Evaluation of cytopathological findings in thyroid nodules with macrocalcification: macrocalcification is not innocent as it seems

The role of the ultrasound scanning in the diagnostics of the thyroid gland of children and adolescents

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