Sonomammographic characteristics of invasive lobular carcinoma

Kombar, Osama; Fahmy, Dalia; Brown, Mary V.; Farouk, Omar; Eldamshety, Osama

doi:10.2147/bctt.s34655

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…US is superior to mammogram at localizing multifocality of ILC and allows for accurate evaluation of size of the lesions [ 4 ]. On US, ILC commonly manifests as an irregular hypoechoic mass with ill-defined or spiculated margins, and posterior acoustic shadowing [ 6 ]. Breast MRI is not only useful for detection of small lesions in high risk patients, but it is also useful for identifying the extent of disease.…”

Section: Discussionmentioning

confidence: 99%

Palpable multifocal and multicentric invasive lobular breast carcinoma in a young female

Qiu

2022

Radiology Case Reports

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Breast cancer is the most common carcinoma plaguing women in the United States. Invasive lobular carcinoma is the second most prevalent type of breast carcinoma with an incidence rate of 5% and 15% with high propensity for multifocal manifestation of disease. Multifocal disease is defined by two or more malignant foci within a single quadrant. Invasive lobular carcinoma is strongly associated with early menarche, late menopause, late age at first birth, and is typically seen in women ages 50 and older. Invasive lobular carcinoma can be difficult to detect clinically because lesions typically fail to form palpable masses, and it can be challenging to diagnose mammographically due to subtle imaging features of the lesions. Here we present a rare case of a palpable, unilateral, multifocal and multicentric lobular breast carcinoma in a young, previously healthy 41-year-old woman with no family history of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Palpable multifocal and multicentric invasive lobular breast carcinoma in a young female

Qiu

2022

Radiology Case Reports

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Association between ultrasound morphologic features and histopathological findings of lobular carcinoma

Malherbe

Bresser

2019

J of Medical Radiation Sci

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Introduction Despite the incidence and recurrence rates of breast cancer, there are currently no biomarkers to predict which cases will develop into lobular carcinoma (LC). The purpose of this study was to determine the association between ultrasound morphologic characteristics of LC and histopathological classifications. Methods A retrospective, cross‐sectional study was conducted on the ultrasound images and histopathological reports of 100 patients with a confirmed LC diagnosis between January 2013 and December 2016. Results Morphologic ultrasound characteristics most frequently reported in the dataset of positively diagnosed LC patients were; irregular ultrasound shape (86%), hypoechoic echogenicity (88%), poorly circumscribed margin (95%), posterior acoustic enhancement (93%) and absent calcifications (81%). Using Fisher's extract test, it was found that stromal fibrosis, single file type pattern, atypical lobular hyperplasia and LC Grade II were significantly correlated with irregular shape and hypoechoic echogenicity. Conclusion A prognostic predictor tool can be designed from this study's findings which can then be used in practice to raise awareness of the unique morphometric markers related to LC of the breast.

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Correlations Between Ultrasonographic Findings of Invasive Lobular Carcinoma of the Breast and Intrinsic Subtypes

Wen

Yang

et al. 2018

Ultraschall in Med

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Purpose To analyze the ultrasonographic findings of invasive lobular carcinoma (ILC) of the breast in 360 women and the correlations between the characteristics and the intrinsic subtypes. Materials and Methods We evaluated the imaging findings according to the lexicon of the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS). The included ultrasonographic features were shape, orientation, margin, echo pattern, posterior features, calcifications, the vascularity of the masses and the presence of architectural distortions. The associations between those features and the intrinsic ILC subtypes were investigated. Results The most common manifestations of ILC on ultrasound (US) were hypoechoic masses with irregular shape, parallel orientation, spiculated margin, posterior acoustic shadowing, no calcification and blood vessels in the rim. The patients in the luminal A subtype were the youngest, and the patients in the HER2 overexpression subtype were the oldest (p = 0.01). On US, the HER2 overexpression subtype was characterized by microlobulated margins (p = 0.002), while the luminal A subtype and the luminal B subtype mostly had spiculated margins. The basal-like subtype was distinctive in that it had no posterior features (p = 0.041), rather than acoustic shadowing, and the masses in the HER2 and basal-like subtypes were larger than in the other two groups (p = 0.03). Conclusion There were significant differences and several trends in the ultrasonographic characteristics of different intrinsic subtypes, which may supply accurate imaging diagnostic criteria to assist in the management of individuals with ILC.

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Sonomammographic characteristics of invasive lobular carcinoma

Cited by 5 publications

References 17 publications

Palpable multifocal and multicentric invasive lobular breast carcinoma in a young female

Palpable multifocal and multicentric invasive lobular breast carcinoma in a young female

Association between ultrasound morphologic features and histopathological findings of lobular carcinoma

Correlations Between Ultrasonographic Findings of Invasive Lobular Carcinoma of the Breast and Intrinsic Subtypes

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