Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model

Belafsky, Peter C.; Peake, Janice L.; Smiley‐Jewell, Suzette; Verma, Sunil P.; Dworkin-Valenti, James; Pinkerton, Kent E.

doi:10.1002/lary.25467

Cited by 17 publications

(5 citation statements)

References 34 publications

(63 reference statements)

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“…Allergic sensitization of drugs is an important health problem with serious clinical consequences [21, 22]. In the pre-clinical evaluation process, guinea pig models are often used to evaluate the allergenicity of drugs [23, 24].…”

Section: Discussionmentioning

confidence: 99%

A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine

Wang

Liu

et al. 2017

PLoS ONE

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Although adjuvants are a common component of many vaccines, there are few adjuvants licensed for use in humans due to concerns about their toxic effects. There is a need to develop new and safe adjuvants, because some existing vaccines have low immunogenicity among certain patient groups. In this study, SBP, a hepatitis B surface antigen binding protein that was discovered through screening a human liver cDNA expression library, was introduced into hepatitis B vaccine. A good laboratory practice, non-clinical safety evaluation was performed to identify the side effects of both SBP and SBP-adjuvanted hepatitis B vaccine. The results indicate that SBP could enhance the HBsAg-specific immune response, thus increasing the protection provided by the hepatitis B vaccine. The safety data obtained here warrant further investigation of SBP as a vaccine adjuvant.

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Section: Discussionmentioning

confidence: 99%

A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine

Wang

Liu

et al. 2017

PLoS ONE

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“…LPR is considered to be one of the common causes of chronic laryngitis, but there are other associated causes as well, as written by Belafsky PC and colleagues utilized an experimental animal model to examine pathogenetic triggers for laryngeal inflammation. The authors concluded that the combination of dust mite antigen and iron soot caused laryngeal eosinophilia with an established guinea pig model of chronic laryngitis thus providing that there were associated predisposing factors that caused dysphonia (30).…”

Section: Discussionmentioning

confidence: 99%

The factors associated with allergic rhinitis in the dysphonic professional voice users

Velickovic¹,

Simovic²,

Živanović³

et al. 2017

Medicinski casopis

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“…Several studies have evaluated the direct effect of allergens on the larynx. Belafsky et al 3268 . and Mouadeb et al 3269 .…”

Section: Associated Conditionsmentioning

confidence: 99%

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise

Damask

Roland

et al. 2023

Int Forum Allergy Rhinol

157

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Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence‐based findings and recommendation from the full document. Methods ICAR‐Allergic Rhinitis 2023 employed established evidence‐based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results ICAR‐Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion The ICAR‐Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

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Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model

Cited by 17 publications

References 34 publications

A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine

A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine

The factors associated with allergic rhinitis in the dysphonic professional voice users

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

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