Sophisticated sleep improves our brains

Hunter, Philip

doi:10.15252/embr.201642044

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Restoring sleep is associated with a broad variety of physical, 1 emotional, 2 , 3 cognitive, 4 , 5 and social benefits. 6 Poor and nonrestoring sleep, in contrast, leads to impairments on physiological, emotional, cognitive, and social levels. In other words, poor sleep is associated with impaired daily functioning.…”

Section: Introductionmentioning

confidence: 99%

Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention

Rahimi

Ahmadpanah

Shamsaei

et al. 2016

NDT

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BackgroundSleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP–LOR).MethodsA total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56.7% females) and treated with a standard SSRI (citalopram at 20–40 mg at therapeutic level) were randomly assigned to one of the following three conditions: SHP (n=40), LOR (1 mg/d; n=40), SHP–LOR (1 mg/d; n=40). At the beginning and at the end of the study 8 weeks later, patients completed two questionnaires, the Pittsburgh Sleep Quality Index to assess sleep and the Beck Depression Inventory to assess symptoms of depression.ResultsSleep disturbances decreased over time and in all groups. No group differences or interactions were observed. Symptoms of depression decreased over time and in all three groups. Reduction in symptoms of depression was greatest in the SHP–LOR group and lowest in the LOR group.ConclusionThe pattern of results suggests that all three adjuvant treatments improved symptoms of sleep disturbances and depression, with greater benefits for the SHP–LOR for symptoms of depression, but not for sleep. Nevertheless, risks and benefits of benzodiazepine prescriptions should be taken into account.

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Section: Introductionmentioning

confidence: 99%

Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention

Rahimi

Ahmadpanah

Shamsaei

et al. 2016

NDT

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“…The need for sleep is a cross-species universal: extensive evidence confirms its necessity despite the costliness of sleep in terms of reduced vigilance [42]. Rats forced to stay awake are more vulnerable to bacterial infections and tumor growth [43].…”

Section: Links Between Short Sleep Evolution and Admentioning

confidence: 99%

Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?

Nesse

Finch

Nunn

2017

Evolution, Medicine, and Public Health

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Compared with other primates, humans sleep less and have a much higher prevalence of Alzheimer ’s disease (AD) pathology. This article reviews evidence relevant to the hypothesis that natural selection for shorter sleep time in humans has compromised the efficacy of physiological mechanisms that protect against AD during sleep. In particular, the glymphatic system drains interstitial fluid from the brain, removing extra-cellular amyloid beta (eAβ) twice as fast during sleep. In addition, melatonin—a peptide hormone that increases markedly during sleep—is an effective antioxidant that inhibits the polymerization of soluble eAβ into insoluble amyloid fibrils that are associated with AD. Sleep deprivation increases plaque formation and AD, which itself disrupts sleep, potentially creating a positive feedback cycle. These and other physiological benefits of sleep may be compromised by short sleep durations. Our hypothesis highlights possible long-term side effects of medications that reduce sleep, and may lead to potential new strategies for preventing and treating AD.

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Dynamic associations between daily alternate healthy eating index, exercise, sleep, seasonal change and mental distress among young and mature men and women

Begdache

Chen

McKenna

et al. 2021

Journal of Affective Disorders Reports

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Sophisticated sleep improves our brains

Abstract: Sleep contributes to humankind's unique cognitive abilities and our mental and physical health. Recent research on the evolution and importance of sleep suggests that sleep is vital to learning and could become an important component of therapies for various mental disorders.

Cited by 3 publications

References 8 publications

Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention

Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention

Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?

Dynamic associations between daily alternate healthy eating index, exercise, sleep, seasonal change and mental distress among young and mature men and women

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