Sophora flavescens Aiton inhibits the production of pro-inflammatory cytokines through inhibition of the NF κB/IκB signal pathway in human mast cell line (HMC-1)

Transcriptome Analysis of Nine Tissues to Discover Genes Involved in the Biosynthesis of Active Ingredients in <i>Sophora flavescens</i>

“…1) As a widely distributed and effective herbal medicine, it severed as a cure for asthma, sores, gastrointestinal hemorrhage, diarrhea, allergy, inflammation in eastern Asian countries. 2,3) Main chemical components of S. flavescens include flavonoids (1.5%), alkaloids (3.3%), alkylxanthones, quinones, triterpene glycosides, fatty acids as well as essential oils and recently, several clinical studies reported that alkaloids of S. flavescens were efficacious in treating various types of solid tumors (including breast, lung, liver and gastrointestinal tract cancers), which drew close attention to this traditional herbal plant. 1,4) In 1889, the characteristic compound matrine was isolated from the dry roots of S. flavescens by Nagai 5) and then in 1966, Okuda et al confirmed the absolute structure of (+)-matrine.…”

Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression

“…In our previous study, we showed the anti allergic effect of Kujin mediated through the suppression of histamine signaling and Th2 cytokines [7]. Inhibition of NF-κB activation by Kujin was also reported [29,30]. All these reports and observations prompt us to know more insight about the mechanism of anti-allergic effect of Kujin and to identify the other genes involved.…”

Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

“…Trifolirhizin, a pterocarpan flavonoid, was isolated from the roots of S. flavescens and showed potential anti-inflammatory and anticancer activities (Zhou et al 2009). Sophora could possibly be used as a treatment for mast cell-derived allergic inflammatory diseases (Hong et al 2009). …”