Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

Sze, Alexandre; Olagnier, David; Hadj, Samar Bel; Han, Xiaoying; Tian, Xiao Hong; Xu, Hongtao; Yang, Long; Shi, Qing; Wang, Penghua; Wainberg, Mark A.; Wu, Jian; Lin, Rongtuan

doi:10.3390/v9100287

Cited by 15 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results presented in this study underscore the entry antagonist as a promising class of antivirals and add D. apetalum to the group of medicinal plant extracts or phytochemicals that interfere with the early stage of the ZIKV replication cycle [11,12,20,41,42,43]. We recently reported that both extracts from Aphloia theiformis and Psiloxylon mauritianum , indigenous medicinal plants from Reunion Island, inactivate cell-free virions, as well as EGCG, impeding virus binding to the host cell surface by deforming ZIKV particles [12,20].…”

Section: Resultsmentioning

confidence: 83%

Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells

Haddad

Koishi

Gaudry

et al. 2019

IJMS

View full text Add to dashboard Cite

Zika virus (ZIKV) and Dengue virus (DENV) are mosquito-borne viruses of the Flavivirus genus that could cause congenital microcephaly and hemorrhage, respectively, in humans, and thus present a risk to global public health. A preventive vaccine against ZIKV remains unavailable, and no specific antiviral drugs against ZIKV and DENV are licensed. Medicinal plants may be a source of natural antiviral drugs which mostly target viral entry. In this study, we evaluate the antiviral activity of Doratoxylum apetalum, an indigenous medicinal plant from the Mascarene Islands, against ZIKV and DENV infection. Our data indicated that D. apetalum exhibited potent antiviral activity against a contemporary epidemic strain of ZIKV and clinical isolates of four DENV serotypes at non-cytotoxic concentrations in human cells. Time-of-drug-addition assays revealed that D. apetalum extract acts on ZIKV entry by preventing the internalisation of virus particles into the host cells. Our data suggest that D. apetalum-mediated ZIKV inhibition relates to virus particle inactivation. We suggest that D. apetalum could be a promising natural source for the development of potential antivirals against medically important flaviviruses.

show abstract

Section: Resultsmentioning

confidence: 83%

Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells

Haddad

Koishi

Gaudry

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…In a dose-dependent manner, the number of expressed cells significantly reduced. This finding also suggested that the polymerase of both flaviviruses was severely inhibited by SFG [104].…”

Section: Natural Inhibitors Of Arbovirusesmentioning

confidence: 67%

Review of Phytochemical Compounds as Antiviral Agents Against Arboviruses from the Genera Flavivirus and Alphavirus

Sardari

Rafieian-Kopaei

Malekmohammad

et al. 2020

CDDT

View full text Add to dashboard Cite

: Arboviruses are a diverse group of viruses that are among the major causes of emerging infectious diseases. Arboviruses from the genera flavivirus and alphavirus are the most important human arboviruses from a public health perspective. During recent decades, these viruses have been responsible for millions of infections and deaths around the world. Over the past few years, several investigations have been carried out to identify antiviral agents to treat these arbovirus infections. The use of synthetic antiviral compounds is often unsatisfactory since they may raise the risk of viral mutation, they are costly and possess either side effects or toxicity. One attractive strategy is the use of plants as promising sources of novel antiviral compounds that present significant inhibitory effects on these viruses. In this review, we describe advances in the exploitation of compounds and extracts from natural sources that target the vital proteins and enzymes involved in arbovirus replication.

show abstract

“…The roots of this herb have been used to treat fever, pain, and several other symptoms (He et al, 2015). Sze et al (2017) identified sophoraflavenone G derived from the roots of S. flavescens as an antiviral compound against DENV and ZIKV. The isolated molecule, sophoraflavenone G (5,7,2',4'-tetrahydroxy-8-lavandulylflavanone), is a flavanone analog of naringenin with two stereogenic centers, bearing an additional hydroxyl substituent at the 2' position and a (2R)-5-methyl-2-(prop-1en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at the 8' position.…”

Section: Sophoraflavenone Gmentioning

confidence: 99%

“…To address the anti-ZIKV mechanism of the compound, the authors performed an RNA-dependent RNA-polymerase (RdRP) activity assay and observed the inhibition of this enzyme. Despite the IC 50 of 22.61 μM and the low selectivity index (SI) of sophoraflavenone G, the specific inhibition of ZIKV-RdRP has the potential to cause fewer side effects in vivo (Sze et al, 2017). However, the in vivo efficacy of sophoraflavenone G against ZIKV needs to be determined.…”

Section: Sophoraflavenone Gmentioning

confidence: 99%

Flavonoids as Molecules With Anti-Zika virus Activity

et al. 2021

View full text Add to dashboard Cite

Zika virus (ZIKV) is an arthropod-born virus that is mainly transmitted to humans by mosquitoes of the genus Aedes spp. Since its first isolation in 1947, only a few human cases had been described until large outbreaks occurred on Yap Island (2007), French Polynesia (2013), and Brazil (2015). Most ZIKV-infected individuals are asymptomatic or present with a self-limiting disease and nonspecific symptoms such as fever, myalgia, and headache. However, in French Polynesia and Brazil, ZIKV outbreaks led to the diagnosis of congenital malformations and microcephaly in newborns and Guillain-Barré syndrome (GBS) in adults. These new clinical presentations raised concern from public health authorities and highlighted the need for anti-Zika treatments and vaccines to control the neurological damage caused by the virus. Despite many efforts in the search for an effective treatment, neither vaccines nor antiviral drugs have become available to control ZIKV infection and/or replication. Flavonoids, a class of natural compounds that are well-known for possessing several biological properties, have shown activity against different viruses. Additionally, the use of flavonoids in some countries as food supplements indicates that these molecules are nontoxic to humans. Thus, here, we summarize knowledge on the use of flavonoids as a source of anti-ZIKV molecules and discuss the gaps and challenges in this area before these compounds can be considered for further preclinical and clinical trials.

show abstract

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

Cited by 15 publications

References 24 publications

Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells

Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells

Review of Phytochemical Compounds as Antiviral Agents Against Arboviruses from the Genera Flavivirus and Alphavirus

Flavonoids as Molecules With Anti-Zika virus Activity

Contact Info

Product

Resources

About