Sophorolipid Biosurfactant Can Control Cutaneous Dermatophytosis Caused by Trichophyton mentagrophytes

Production of Sophorolipid Biosurfactant by Insect Derived Novel Yeast Metschnikowia churdharensis f.a., sp. nov., and Its Antifungal Activity Against Plant and Human Pathogens

“…Upon treatment with biosurfactant from CIG-6A T , live and dead cells of F. solani, stained with PI were visualized by CLSM, that confirm the irreversible damage to membrane integrity and structure damage. Previously, (Sen et al, 2020) demonstrated permeabilization of Trichophyton mentagrophytes membrane on treatment with sophorlipid produced by R. babjevae. Sophorolipid from CIG-6A T has seven homologs of lactonic analog in contrast to two homologs of acidic analog, giving it more lipophilic character.…”

“…Cells of F. solani were grown in the liquid medium to late logarithmic phase and 1 ml culture was centrifuged for 3 min at 1,000 g, washed and incubated with biosurfactant for two different time intervals (48 and 72 h) at 25 • C. After each time point, cells were washed and resuspended in PBS containing PI (10 µmol −1 ) (Sen et al, 2020). Samples were incubated for 15 min and washed with PBS.…”

Biosurfactants: The green generation of speciality chemicals and potential production using Solid-State fermentation (SSF) technology

“…As previously mentioned, BS may be used in cosmetics, not only for their formulation properties but also for their valuable bioactivities. In this regards, yeast biosurfactants showed promising results to treat dermatophytosis caused by Trichophyton mentagrophytes (Sen et al, 2020). A mouthwash containing a mixture of biosurfactants from Pseudomonas aeruginosa and Candida bombicola (now Starmerella bombicola) was effective against cariogenic microorganisms and was significantly less toxic than commercially available mouthwashes (Farias et…”

Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations

“…Moreover, the movement of compounds across the membrane of skin cells is dependent on their lipophilicity and surface activity, therefore, the unique structure of biosurfactants offers them a high rate of permeability through the membrane of skin cells to regulate protein and skin barrier functions, and trigger beneficial effects relating to hair repair and skin protection mechanisms [ 9 , 31 , 57 ]. Additionally, several in vitro studies have demonstrated that rhamnolipids, sophorolipids, MELs and surfactin are compatible with the human skin [ 22 , 31 , 58 ]. Furthermore, their emulsification, foaming, wetting and solubilizing functions, which are dependent on their chemical structure, make them desirable for use as ingredients in creams, lotions, powder, shampoos and other essential cosmetic products applied on the skin [ 59 ].…”

“…Nevertheless, during this period, their interaction with the skin and its associated cells could affect the structural integrity of the stratum corneum, denature proteins, and solubilize intracellular lipids [ 47 ]. Microbial biosurfactants proposed as substitutes for chemical surfactants have been demonstrated to be compatible with the human skin and provide excellent skin surface moisturization [ 22 , 31 , 58 , 117 ]. The MELs produced by Candida spp.…”