Sophorolipid biosurfactants: Possible uses as antibacterial and antibiofilm agent

Rienzo, Mayri Alejandra Dìaz De; Banat, Ibrahim M.; Dolman, Ben; Winterburn, James; Martin, Peter

doi:10.1016/j.nbt.2015.02.009

Cited by 193 publications

(117 citation statements)

References 36 publications

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“…Several reports have demonstrated the ability of biosurfactants to inhibit and/or kill microorganisms, for example, with natural lipopeptides (Banat, Díaz De Rienzo and Quinn 2014;Cochrane et al 2015), rhamnolipids (Díaz De Rienzo et al 2016a,b) and Sophorolipids (Díaz de Rienzo et al 2015Rienzo et al , 2016c. It has also been reported that they are able to alter a substrate's surface energy (Busscher and van der Mei 1997) and increase surface area (Rodrigues et al 2006), which would make biosurfactants important potential candidates for oral health-related applications.…”

Section: Potential Biosurfactant Applications For Oral Health and Hygmentioning

confidence: 99%

Biosurfactants: promising bioactive molecules for oral-related health applications

Elshikh¹,

Marchant²,

Banat³

2016

FEMS Microbiology Letters

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One sentence summary: Biosurfactant properties including antimicrobial activity, emulsion formation and the ability to increase bioavailability of hydrophobic compounds make them potential candidates for use in cosmetic, therapeutic, oral hygiene and medical devices. Editor: Geertje van Keulen ABSTRACTBiosurfactants are naturally produced molecules that demonstrate potentially useful properties such as the ability to reduce surface tensions between different phases. Besides having similar properties to their artificial chemical counterparts, they are regarded as environmental friendly, biodegradable and less toxic, which make them desirable candidates for downstream applications. The structure-activity-related properties of the biosurfactants which are directly correlated with potency of the biosurfactants as antimicrobial agents, the ability of the biosurfactants to alter surface energies and their ability to increase bioavailability are particularly what attract researchers to exploit their potential use in the oral-related health applications. Current research into biosurfactant indicates significant future potential for use in cosmetic and therapeutic oral hygiene product formulations and related medical device treatments.

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Section: Potential Biosurfactant Applications For Oral Health and Hygmentioning

confidence: 99%

Biosurfactants: promising bioactive molecules for oral-related health applications

Elshikh¹,

Marchant²,

Banat³

2016

FEMS Microbiology Letters

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“…The hydroxy fatty acids are generally 16 or 18 carbon atoms in length and may possess multiple olefinic groups. SLs have been shown to possess various antimicrobial properties against bacteria and fungi (Lang and Wagner, 1993; Kitamoto et al, 2002; Ashby et al, 2011; De Rienzo et al, 2015; Zhang et al, 2016). The antibacterial activity of SLs against Rhodococcus erythropolis , Bacillus subtilis , Staphylococcus epidermidis , Streptococcus agalactiae , Moraxella sp., Pseudomonas putida , Enterobacter aerogenes , and E. coli was evaluated by Shah et al (2007).…”

Section: Introductionmentioning

confidence: 99%

“…It is known that physicochemical and biological properties of SLs are significantly influenced by the distribution of the lactone vs. free-acid forms in the fermentative broth (Van Bogaert et al, 2007; Sleiman et al, 2009; De Rienzo et al, 2015; Maddikeri et al, 2015). The specific fatty acids used in the growth medium also influence the composition of SLs.…”

Section: Introductionmentioning

confidence: 99%

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Inactivation of Salmonella spp. and Listeria spp. by Palmitic, Stearic, and Oleic Acid Sophorolipids and Thiamine Dilauryl Sulfate

et al. 2016

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Food contaminated with human pathogens, such as Salmonella spp. and Listeria monocytogenes, frequently causes outbreaks of foodborne illness. Consumer concern over the use of synthesized antimicrobials to enhance microbial food safety has led to a search of natural alternatives. The objectives of this study were to evaluate the antimicrobial activity of various types of sophorolipids (SLs) and thiamine dilauryl sulfate (TDS) against pathogenic Salmonella spp. and Listeria spp. Both free and lactonic forms of SLs were synthesized from Candida bombicola using palmitic, stearic, and oleic acids as co-feedstocks. TDS and purified SLs were used to treat cocktails of Salmonella spp. and Listeria spp. Results showed that lactonic SLs had higher antimicrobial activity than the free-acid form, and Gram-positive Listeria spp. were more susceptible to SLs and TDS than Gram-negative Salmonella spp. Listeria populations were reduced from an initial concentration of 7.2 log CFU/mL to a non-detectible level within a 1 min treatment of 0.1% (w/v) lactonic SLs and TDS in the presence of 20% ethanol, which itself did not significantly reduce the populations. There were no significant differences in the antimicrobial efficacy among palmitic, stearic, and oleic acid-based SLs against Salmonella or Listeria spp. Ethanol was utilized to improve the antimicrobial activity of free-acid SLs against Gram-negative bacteria. In general, TDS was more effective than the SLs against Salmonella and Listeria spp. scanning electron microscopy and transmission electron microscopy images showed that SLs and TDS damaged Listeria cell membranes and resulted in cell lysis. Overall, our results demonstrated that SLs and TDS in the presence of ethanol can be used to inactivate foodborne pathogens, especially Gram-positive bacteria.

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“…SLs possess a sophorose backbone structure with a variety of acyl groups at the 6 and 6′-positions, and a hydroxyl fatty acid. 1,4) These compounds have excellent surface active properties, and they exhibit antimicrobial, 10,11) anticancer, 12) and antiviral activities. 13) They are also highly biodegradable in the environment.…”

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confidence: 99%

Isolation of yeast candidates for efficient sophorolipids production: their production potentials associate to their lineage

Konishi

Fujita

Ishibane

et al. 2016

Bioscience, Biotechnology, and Biochemistry

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Eleven biosurfactant-producing strains were newly isolated from environmental samples using a drop-collapse assay and thin-layer chromatography (TLC). According to the TLC analysis, the separation patterns of the glycolipid spots of nine dominant strains corresponded to that of the sophorolipids produced by a Starmerella bombicola type strain. The retention factor values of the spot patterns of two strains were less than those of the others. Two representative major products were purified, and their molecular structures were determined. The major products were identified as diacetylated lactonic and acidic sophorolipids. The fatty acid moieties of both compounds were estimated to be 17-hydroxymethyl hexadecenoic acid. The amounts of glycolipids ranged from 5.0 to 22.9 g/L after 4 d of cultivation. According to a phylogenetic analysis, the strains were identified as Starmerella bombicola and Candida floricola.

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Sophorolipid biosurfactants: Possible uses as antibacterial and antibiofilm agent

Cited by 193 publications

References 36 publications

Biosurfactants: promising bioactive molecules for oral-related health applications

Biosurfactants: promising bioactive molecules for oral-related health applications

Inactivation of Salmonella spp. and Listeria spp. by Palmitic, Stearic, and Oleic Acid Sophorolipids and Thiamine Dilauryl Sulfate

Isolation of yeast candidates for efficient sophorolipids production: their production potentials associate to their lineage

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