Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance

Tang, Maomao; Huang, Yuzhe; Liang, Xiao; Tao, Yaotian; He, Ning; Li, Zhenbao; Guo, Jian; Gui, Shuangying

doi:10.1208/s12249-022-02214-y

Cited by 11 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the literature [ 45 ], SFN-loaded PLGA (SP) NPs were prepared for the following in vitro and in vivo studies. Using a transmission electron microscope, prepared SP NPs were examined ( Figure 1 A).…”

Section: Resultsmentioning

confidence: 99%

PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

Wang

Liu

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in combination with microwave (MW) hyperthermia for RT sensitization. SPH with stable properties was produced by combining SFN and PLGA in a specific ratio and encapsulating the mixture in agarose hydrogel. Intratumoral injection of SPH to mice combined with MW hyperthermia can not only directly cause thermal damage to tumor cells, but also increase blood oxygen delivery to the tumor site, thus overcoming the problem of intratumoral hypoxia and achieving “first layer” RT sensitization. Moreover, high temperatures can cause the hydrogel to disintegrate and release SFN. Not only can SFN inhibit tumor growth, but it can also achieve the “second layer” of RT sensitization by inhibiting glutathione (GSH) synthesis in cells and increasing reactive oxygen species (ROS) production. Experiments, both in vitro and in vivo, have indicated that SPH and MW hyperthermia can achieve a double RT sensitization effect and a significant tumor inhibition effect. In conclusion, combining our SPH nanosystem and thermoradiotherapy is a promising anti-tumor treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

Wang

Liu

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Further, the researchers prepared polylactic acid-glycolic acid - D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles (SPTNs) loading sorafenib. In vivo and in vitro experiments showed that the uptake of SPTNs by HCC cells increased by 1.6 times, and the particles could inhibit the expression of multidrug resistance-related genes in HCC cells, which showed a good antitumor effect ( Tang et al, 2022 ). The exosome system including multiple siRNAs, SP94 peptide, U1-A’s n-terminal RNA recognition motif and exosomal membrane protein Lamp2b has been confirmed to enhance sorafenib-induced ferroptosis and inhibit sorafenib resistance ( Li et al, 2022 ).…”

Section: The Applications Of Nanotechnology-based Drugs In Hcc Treatmentmentioning

confidence: 99%

The improving strategies and applications of nanotechnology-based drugs in hepatocellular carcinoma treatment

Ren,

Su,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the leading causes of tumor-related death worldwide. Conventional treatments for HCC include drugs, radiation, and surgery. Despite the unremitting efforts of researchers, the curative effect of HCC has been greatly improved, but because HCC is often found in the middle and late stages, the curative effect is still not satisfactory, and the 5-year survival rate is still low. Nanomedicine is a potential subject, which has been applied to the treatment of HCC and has achieved promising results. Here, we summarized the factors affecting the efficacy of drugs in HCC treatment and the strategies for improving the efficacy of nanotechnology-based drugs in HCC, reviewed the recent applications’ progress on nanotechnology-based drugs in HCC treatment, and discussed the future perspectives and challenges of nanotechnology-based drugs in HCC treatment.

show abstract

Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions

Zhang

et al. 2023

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Kaempferol (KAE) is a natural avonoid compound with antitumor activity. However, the low aqueous solubility, poor chemical stability and suboptimal bioavailability greatly restricted its clinical application of cancer. In order to overcome these shortages and enhance the antitumor effect of KAE, we developed a kaempferol nanosuspensions (KAE-NSps) with D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) as stabilizer, screened the optimal preparation process, and investigated the basic properties and the antitumor effect in the study. The results demonstrated that the particle size was 186.6 ± 2.6 nm of the TPGS-KAE-NSps optimized, the shape of which was fusiform under the transmission electron microscope. The 2% (w/v) glucose was used as the cryoprotectant for TPGS-KAE-NSps, whose drug loading content was 70.31 ± 2.11%, and the solubility was improved prominently compared to KAE. The stability and biocompatibility of TPGS-KAE-NSps were favorable, which had a certain sustained release effect. Moreover, TPGS-KAE-NSps clearly seen to be taken in the cytoplasm exhibited a stronger cytotoxicity and suppression of cell migration, higher apoptosis rate and more intracellular ROS production compared to KAE in vitro cell experiments. In addition, TPGS-KAE-NSps showed a stronger inhibition of tumor growth (the tumor inhibition rate of high dose intravenous injection group was 68.9 ± 1.46%) than KAE with no obvious toxicity on 4T1 tumor-bearing mice. Overall, TPGS-KAE-NSps prepared improved the defect and the antitumor effect of KAE notably, which was a promising nanodrug delivery system for KAE and was expected to become a clinical antitumor drug.

show abstract

Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance

Cited by 11 publications

References 36 publications

PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

The improving strategies and applications of nanotechnology-based drugs in hepatocellular carcinoma treatment

Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions

Contact Info

Product

Resources

About