“…The BRISK-FL and LiGHT trials showed that brivanib and linifanib are not superior and, moreover, not noninferior, despite the fact that the trial designs allowed for assessment of noninferiority [5,6]. A superiority trial of sorafenib plus erlotinib (SEARCH trial) [7], a superiority trial of sorafenib plus doxorubicin (CALGB808028 trial), and a trial investigating sorafenib plus hepatic arterial infusion chemotherapy (HAIC) (SILIUS trial) [8] all failed. The results of two superiority trials comparing sorafenib with radioembolization called SARAH (SorAfenib versus Radioembolization in Advanced Hepatocellular carcinoma) [9] and SIRveNIB (Study to Compare Selective Internal Radiation Therapy [SIRT] Versus Sorafenib in Locally Advanced Hepatocellular Carcinoma [HCC]) were also reported at EASL 2017 and ASCO 2017, although these trials failed as well [10].…”