Sorafenib tosylate loaded superparamagnetic nanoparticles: Development, optimization and cytotoxicity analysis on HepG2 human hepatocellular carcinoma cell line

Dahiya, Mandeep; Awasthi, Rajendra; Dua, Kamal; Dureja, Harish

doi:10.1016/j.jddst.2022.104044

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…The resulting nanostructure underwent vacuum drying at 45 °C. The loading entrapment efficiency (%EE) [ 39 ] of VNB into Fe 3 O 4 NPs was calculated using Equation 1 ; it was found that the entrapment efficiency was approximately 98%.…”

Section: Methodsmentioning

confidence: 99%

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

Özcan,

Hazar Yoruç

2024

Beilstein J. Nanotechnol.

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In this study, a multifunctional therapeutic agent combining chemotherapy and photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight ratios as a result of dopamine polymerisation and covalent bonding of thiol-polyethylene glycol (SH-PEG). The VNB/PDA/Fe3O4 nanoparticles have a saturation magnetisation value of 60.40 emu/g in vibrating sample magnetometry, which proves their magnetisation. Vinorelbine, which is used as an effective cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design, magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research.

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Section: Methodsmentioning

confidence: 99%

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

Özcan,

Hazar Yoruç

2024

Beilstein J. Nanotechnol.

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“…The optimized formulation was subjected to stability assessment at different storage conditions, such as 4±1 °C and 25±2 °C / 60±5 % of relative humidity (RH) for 3 months was carried out [ 28 ]. The results of the stability study were reported in terms of physical appearance, vesicle size, morphology, and zeta potential.…”

Section: Methodsmentioning

confidence: 99%

Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

Singh,

Awasthi

2024

ADMET DMPK

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Introduction: Berberine is a poorly water-soluble alkaloid compound showing significant anti-inflammatory characteristics. It reduces the levels of pro-inflammatory and inflammatory cytokines, including tumour necrosis factor (TNF-????, IFN-????) and interleukin (IL-23, IL-12, and IL-23). Diacerein significantly reduces the splenomegaly associated with psoriasis. It downregulates the production of TNF-α and IL-12. Method: This study reported the development of transferosomes containing berberine HCl and diacerein using a film hydration method followed by optimization using a Box-Behnken design. Sodium deoxycholate was used as an edge activator. The impact of independent variables (amount of phosphatidylcholine, amount of edge activator, and sonication cycles) on dependent variables (particle size and entrapment efficiency) was examined. The optimized formulation was characterized for polydispersity index, vesicle size, entrapment efficiency, ζ potential, spectral analysis like Fourier transform infrared, thermal analysis, X-ray diffraction, deformability, transmission electron microscopy, antioxidant assay, in-vitro release, and ex-vivo skin permeation studies. Results: The optimized formulation had a particle size of 110.90±2.8 nm with high entrapment efficiency (89.50±1.5 of berberine HCl and 91.23±1.8 of diacerein). Deformability, polydispersity index, ζ potential, and antioxidant activity of the optimized formulation were 2.44, 0.296, -13.3, and 38.36 %, respectively. Optimized transferosomes exhibited 82.093±0.81 % and 85.02±3.81 % release of berberine HCl and diacerein after 24 h of dissolution study. The transdermal flux of optimized formulation was 0.0224 µg cm-2 h-1 (2.24 cm h-1 permeation coefficient) and 0.0462 µg cm-2 h-1 (4.62 cm h-1 permeation coefficient), respectively, for berberine HCl and diacerein. Raman analysis of treated pig skin confirmed that the transferosomes can permeate the skin. No change in the skin condition or irritation was observed in BALB/c mice. Formulation stored at 4 and 25±2 °C / 60±5 % relative humidity was stable for 3 months. Conclusions: Thus, the results demonstrated successful optimization of the transferosomes for the efficient topical delivery of berberine HCl and diacerein in the effective management of psoriasis.

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“…The following coupling reaction between chitosan and epoxy ring of the AGE afforded thermosensitive magnetic nanocarrier (TSMNC). Due to superparamagnetic properties, rapid adsorption and slow release at low and high temperatures, Fickian diffusion-controlled drug release was obtained, where about 88% of SF was released within 35 h at 45 • C. Recently, SF tosylate-loaded PCL-superparamagnetic nanoparticles were prepared by an emulsion solvent evaporation method and optimized using Box-Behnken design [74]. A dicarboxylic acid-containing ICG was selected as a NIR photosensitizer and fluorescent dye, which was co-loaded with SF by Pluronic F127 to produce self-assembled and self-monitored nanodrug [79].…”

Section: Imaging-guided Sf Nanodrugsmentioning

confidence: 99%

“…Due to superparamagnetic properties, rapid adsorption and slow release at low and high temperatures, Fickian diffusion-controlled drug release was obtained, where about 88% of SF was released within 35 h at 45 °C. Recently, SF tosylate-loaded PCL-superparamagnetic nanoparticles were prepared by an emulsion solvent evaporation method and optimized using Box–Behnken design [ 74 ].…”

Section: Sf-based Nanomedicinementioning

confidence: 99%

Sorafenib-Based Drug Delivery Systems: Applications and Perspectives

et al. 2023

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As a Food and Drug Administration (FDA)-approved molecular-targeted chemotherapeutic drug, sorafenib (SF) can inhibit angiogenesis and tumor cell proliferation, leading to improved patient overall survival of hepatocellular carcinoma (HCC). In addition, SF is an oral multikinase inhibitor as a single-agent therapy in renal cell carcinoma. However, the poor aqueous solubility, low bioavailability, unfavorable pharmacokinetic properties and undesirable side effects (anorexia, gastrointestinal bleeding, and severe skin toxicity, etc.) seriously limit its clinical application. To overcome these drawbacks, the entrapment of SF into nanocarriers by nanoformulations is an effective strategy, which delivers SF in a target tumor with decreased adverse effects and improved treatment efficacy. In this review, significant advances and design strategies of SF nanodelivery systems from 2012 to 2023 are summarized. The review is organized by type of carriers including natural biomacromolecule (lipid, chitosan, cyclodextrin, etc.); synthetic polymer (poly(lactic-co-glycolic acid), polyethyleneimine, brush copolymer, etc.); mesoporous silica; gold nanoparticles; and others. Co-delivery of SF and other active agents (glypican-3, hyaluronic acid, apolipoprotein peptide, folate, and superparamagnetic iron oxide nanoparticles) for targeted SF nanosystems and synergistic drug combinations are also highlighted. All these studies showed promising results for targeted treatment of HCC and other cancers by SF-based nanomedicines. The outlook, challenges and future opportunities for the development of SF-based drug delivery are presented.

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Sorafenib tosylate loaded superparamagnetic nanoparticles: Development, optimization and cytotoxicity analysis on HepG2 human hepatocellular carcinoma cell line

Cited by 5 publications

References 46 publications

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

Sorafenib-Based Drug Delivery Systems: Applications and Perspectives

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