“…However, the research in this field is mainly centered in the manufacturing process, so the application of such microdevices is rather limited. In the coming years research in this field will focus on exploring the potential of chip-based SPE-CE for its application in the analysis of real samples (Puig et al, 2007(Puig et al, , 2008. SPE is the most attractive way of coupling extraction with CE and, especially, MCE, particularly as it can provide significant improvements in sensitivity without the use of electrokinetic injection (Puig et al, 2007(Puig et al, , 2008Bertoncini & Hennion, 2004).…”