Sorbitol, Rubus fruit, and misconception

Lee, Jungmin

doi:10.1016/j.foodchem.2014.06.073

Cited by 37 publications

(22 citation statements)

References 63 publications

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“…Most fruits are well known to be rich sources of naturally occurring sugars, particularly simple sugars such as glucose, sucrose, fructose, etc. [32]. Therefore, consuming an increased proportion of fruit containing higher amounts of sugars in the daily diet may directly increase the ingestion of simple sugars to positively influence the body energy equilibrium.…”

Section: Probable Mechanisms For the Pro-obesity Effect Of Fruitmentioning

confidence: 99%

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Paradoxical Effects of Fruit on Obesity

et al. 2016

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Obesity is exponentially increasing regardless of its preventable characteristics. The current measures for preventing obesity have failed to address the severity and prevalence of obesity, so alternative approaches based on nutritional and diet changes are attracting attention for the treatment of obesity. Fruit contains large amounts of simple sugars (glucose, fructose, sucrose, etc.), which are well known to induce obesity. Thus, considering the amount of simple sugars found in fruit, it is reasonable to expect that their consumption should contribute to obesity rather than weight reduction. However, epidemiological research has consistently shown that most types of fruit have anti-obesity effects. Thus, due to their anti-obesity effects as well as their vitamin and mineral contents, health organizations are suggesting the consumption of fruit for weight reduction purposes. These contradictory characteristics of fruit with respect to human body weight management motivated us to study previous research to understand the contribution of different types of fruit to weight management. In this review article, we analyze and discuss the relationships between fruit and their anti-obesity effects based on numerous possible underlying mechanisms, and we conclude that each type of fruit has different effects on body weight.

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Section: Probable Mechanisms For the Pro-obesity Effect Of Fruitmentioning

confidence: 99%

“…Most types of fruit have very high simple sugar content, such as sucrose, fructose, glucose, etc. [32]. Thus, considering that the overconsumption of simple sugars is one of the main causes of obesity and related diseases [33,34,35], it is perhaps surprising that the consumption of fruit is associated with anti-obesity in most cases.…”

Section: Introductionmentioning

confidence: 99%

Paradoxical Effects of Fruit on Obesity

et al. 2016

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“…When eaten, sorbitol has a mouth-cooling sensation, with virtually no aftertaste. Sorbitol offers disadvantages in the intestine by causing water retention, resulting in diarrhoea 74,75,76 .…”

Section: Fig 9: Trehalosementioning

confidence: 99%

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2019

IJPSR

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Background: Due to the rise of diabetes as the primary health issue nowadays, there is a need for a sweetener, which apart from fulfilling the role of a sweetener, also complies with the normal body metabolism. Objectives: To review the literature available on the different sugar alternates present globally. Methods: A literature search has been done on the various substitutes of sugar present, belonging to various categories such as artificial sweeteners, natural sweeteners, novel sweeteners, and sugar alcohols. Results: A vast variety of sugar substitutes are available, which are suitable in one or more ways. The main matter of concern is the selection of the right sweetener according to the requirement. Conclusion: Apart from being of low calorie, these sweeteners provide multiple advantages; therefore by choice of right alternate, consumers are benefitted with the sweet taste, thereby complying with the normal body metabolism.

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“…The antioxidant effect of R. anatolicus leaves is due to high phenolic compounds, which have antioxidant and free radical scavenging activities. [21][22][23][24] Free radicals and oxidative stress that results from overproduction of reactive oxygen species (ROS) are closely associated with a number of disease states such as hyperglycemia and metabolic disorders including diabetes mellitus. 25 Therefore, it is reasonable that dietary antioxidants, especially polyphenolic compounds that present in wild plants can neutralize free radicals and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of <em>Rubus anatolicus</em> Leaf Extract on Glucose Metabolism in HepG2, CRI-D2 and C2C12 Cell Lines</p>

Safarzad¹,

Marjani²,

Jazi³

et al. 2020

DMSO

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The aim of this study was to assess the effects of Rubus anatolicus on glucose metabolism in HepG2, CRI-D2 and C2C12 cell lines. Materials and Methods: R. anatolicus was collected in Golestan province, Iran. Three different cell lines HepG2 (human liver cell), CRI-D2 (mice pancreatic cell) and C2C12 (rat myoblast) were used for cell culture experiments. Cell viability was measured using MTT assay. Cells were treated with various concentrations of the extract (6.25-400 μg/mL) and then the extracellular glucose level and intracellular glycogen content were measured using colorimetric methods. The insulin level of the culture medium was measured using the ELISA method. Results: Our findings showed that R. anatolicus extract enhances glucose uptake and consumption by all three cell lines. The R. anatolicus extract exposure also elevated cellular glycogen content in HepG2 and C2C12 cells (for 200 and 100 μg/mL) significantly. We found a significant increase in glucose uptake and consequently higher stimulation of insulin secretion in CRI-D2 cell pancreatic cells treated with R. anatolicus extract. Conclusion: The R. anatolicus appears to activate glucose uptake and cellular glycogen synthesis probably by activating the glycogenesis or inhibition of glycogenolysis pathways. The extract enhances insulin secretion in the pancreatic cells by increased glucose uptake.

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Sorbitol, Rubus fruit, and misconception

Cited by 37 publications

References 63 publications

Paradoxical Effects of Fruit on Obesity

Paradoxical Effects of Fruit on Obesity

Untitled

<p>Effect of <em>Rubus anatolicus</em> Leaf Extract on Glucose Metabolism in HepG2, CRI-D2 and C2C12 Cell Lines</p>

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