Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing the Efficiency of Tumor Chemotherapy

Исайкина, Н. В.; Калинкина, Г. И.; Разина, Т. Г.; Зуева, Е. П.; Rybalkina, O. Yu.; Ulirich, A. V.; Федорова, Е. П.; Shilova, A. B.

doi:10.1134/s1068162018070038

Cited by 13 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chlorogenic (3- O -caffeoylquinic acid, 3–CQA) and neochlorogenic (5- O -caffeoylquinic acid, 5–CQA) acids represent the most abundant phenolic acids [ 10 ], accounting for 56–80% of the total phenolic content in Sorbus berries [ 8 ]. Cinnamic, vanillic, p–coumaric and benzoic acids were detected only in trace amounts in the fruits of S. aucuparia [ 33 ] and S. domestica [ 34 ]; p–coumaric acid was determined in S. discolor fruits as well [ 35 ]. Raudonis et al (2014) established a significant variability in the contents of phenolic acid and flavonoid substances and the levels of antioxidant activity in the fruits of the Sorbus species, which is in accordance with the results of this study [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Total Phenolic and Total Flavonoid Content, Individual Phenolic Compounds and Antioxidant Activity in Sweet Rowanberry Cultivars

et al. 2023

View full text Add to dashboard Cite

Sweet rowanberry and its cultivars represent a less-known fruit species with significant antioxidant activity, mostly promoted by polyphenolic compounds. This paper examined seven Sorbus cultivars and evaluated their total polyphenolic and flavonoid content, as well as the content of individual polyphenolic compounds from the group of phenolic acids and flavonoids. It also determined their antioxidant activity using DPPH, ACW and ACL. Furthermore, to reflect the distribution of the contribution to antioxidant activity, correlations between antioxidant activity and the contents of ascorbic acid, vitamin E and individual phenolic compounds were established. The highest total phenolic content of 8307.4 mg kg−1 was determined in ‘Granatina’, with the main contribution of phenolic acid content of 7001.7 mg kg−1 and a significantly lower total flavonoid content of 1304.6 mg kg−1. Flavanols represented the most abundant group of flavonoids, with catechin being the second most frequent flavanol with the highest content of 633.67 mg kg−1 in ‘Granatina’. Flavonols were represented by rutin and quercetin. ‘Businka’ displayed a significant vitamin E content of 4.77 mg kg−1, and ‘Alaja Krupnaja’ had the highest vitamin C level of 7.89 g kg−1. These results emphasize their potential health and nutritional benefits and, thus, their promising and valuable role in the food processing industry.

show abstract

Section: Resultsmentioning

confidence: 99%

Total Phenolic and Total Flavonoid Content, Individual Phenolic Compounds and Antioxidant Activity in Sweet Rowanberry Cultivars

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Therapy with the extract alone or in combination with cyclophosphamide markedly decreased the tumor growth in both cases. Similarly, Isaikina et al (2018) revealed a potential antitumor activity of acidified 95% ethanol extract from rowanberries in C57BL/6 female mice with transferred Lewis lung carcinoma.…”

Section: Cytotoxic Activitymentioning

confidence: 92%

“…Raudon_ e et al (2015), Klensporf-Pawlik and Przybylski (2015), Š avikin et al (2017), Tian et al (2017), Turumtay et al (2017),Mrkonjić et al (2017) andIsaikina et al (2018) …”

mentioning

confidence: 99%

Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

2020

View full text Add to dashboard Cite

Sorbus L. sensu lato (Rosaceae family) comprises over 250 trees and shrubs growing in the Northern Hemisphere. Several Sorbus species have found their way into traditonal materia medica, as different leaf, bark or fruit preparations have a longstanding folk use. Ethnomedicine recommends their use not only in respiratory and gastrointestinal system disorders, but also in rheumatism, cancer or diabetes. Chemical composition of the genus Sorbus has been studied since 1960s and until now more than 250 compounds have been identified from thirty-eight species. The most thoroughly investigated substances are phenolic compounds (flavonoids and phenolic acids). Other constituents include triterpenes, sterols, carboxylic acids, coumarins and cyanogenic glycosides. Biological activity studies performed on the representatives of the genus Sorbus have been predominantly conducted on extracts prepared with the use of different solvents, and more rarely on isolated constituents. The majority of these studies were devoted to determination of antioxidant potential of Sorbus extracts. In a few cases targeted studies were conducted to confirm specific folk usage. Two of the fairly well documented medicinal uses are the antidiabetic activity of Sorbus decora and antiinflammatory activity of Sorbus commixta. Keywords Sorbus Á Folk medicine Á Phytochemistry Á Biological activity Abbreviations AAPH 2,2 0 -Azobis-(2-amidinopropane) dihydrochloride ABTS 2,2 0 -Azino-bis(3-ethylbenzothioazoline-6sulphonic acid) diammonium salt ACE Angiotensin converting enzyme AChE Acetylcholinesterase ADH Alcohol dehydrogenase ALT Alanine aminotransferase AMPK Adenosine-monophosphate-activated protein kinase AST Aspartate transaminase ATO Arsenic trioxide BChE Butyrylcholinesterase CAT Catalase CD Conjugated dienes cGMP Guanosine 3 0 ,5 0 -cyclic monophosphate COX-2 Cyclooxygenase-2 CYP Cytochrome P450 DMPD ? N,N-Dimethyl-p-phenylenediamine DPPH 2,2 0 -Diphenyl-1-picrylhydrazyl dw Dry weight ecNOS Endothelial cell NO synthase EDTA Ethylenediamine tetraacetic acid

show abstract

“…Some other well-known phenolic acids and their derivatives such as cinnamic, vanillic, p-coumaric and benzoic acids have been found in traces in the fruits of S. aucuparia [64] and S. domestica [41], while p-coumaric acid was also detected in the S. discolor berries [40]. Caffeic acid and its derivatives were reported in the berries of S. aucuparia [40], S. domestica [62], S. discolor [40], S. alnifolia [62], S. pohuashanensis [16], S. torminalis [40].…”

Section: Phenolic Acidsmentioning

confidence: 99%

The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential

2020

View full text Add to dashboard Cite

The Sorbus spp. are valuable plants, which have been used for ornamental purposes, in traditional medicines and less seldom in foods. Recent studies have revealed different anatomical parts of the Sorbus spp. to contain valuable phytochemicals demonstrating various bioactivities. However, in terms of applications in the products intended for human consumption, Sorbus still remains as an underutilised genus. The increasing number of studies on phytochemicals, antioxidant potential and other bioactivities of Sorbus extracts has revealed the prospects of expanding its use in natural medicines, cosmetics and as innovative food ingredients, which might find wider applications in functional foods and/or nutraceuticals. Caffeoylquinic acids, flavonoids and proanthocyanidins have been reported in various Sorbus spp. as the most abundant polyphenolic antioxidants. The preparations of various plant anatomical parts have been used in ethnopharmacology as natural remedy for treating bacterial, viral, inflammatory diseases including tumors. Sorbus spp. plant parts have also been tested for management of diabetes, neurological, and cardiovascular disorders. The present review is focused on Sorbus plants (in total 27 Sorbus spp.), their composition and properties in terms of developing promising ingredients for foods, nutraceutical, cosmeceutical and other applications. It is expected that this review will assist in designing further studies of rowans and other Sorbus spp. in order to expand their uses for various human applications.

show abstract

Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing the Efficiency of Tumor Chemotherapy

Cited by 13 publications

References 7 publications

Total Phenolic and Total Flavonoid Content, Individual Phenolic Compounds and Antioxidant Activity in Sweet Rowanberry Cultivars

Total Phenolic and Total Flavonoid Content, Individual Phenolic Compounds and Antioxidant Activity in Sweet Rowanberry Cultivars

Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review

The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential

Contact Info

Product

Resources

About