The mass and heat transport of Casson nanofluid flow in a channel under the influence of the magnetic field, heat generation, chemical reaction, ramped concentration, and ramped temperature is studied. Nanoparticles of copper (Cu) are inserted in sodium alginate (SA) to make nanofluid. The definition of time-fractional Caputo derivative is applied to have the fractional model. The analytical results of concentration, temperature, velocity, skin friction, Sherwood numbers, and Nusselt numbers for ramped and isothermal boundary conditions are obtained in the form of summation after applying the Laplace inverse transform. The effects of the fractional parameter (
ξ
) and physical parameters are depicted graphically. For higher values of
ξ
the velocity, concentration and temperature reduce. The fractional model is a better choice to control velocity, concentration, and temperature profiles. The energy enhances by increasing volume fraction (
ϕ
), whereas mass and flow of nanofluid reduce. The Sherwood and Nusselt numbers for both isothermal and ramped conditions increase by increasing
ϕ
. Ramped conditions can control the flow, mass, and heat of the nanofluid.