In this study, reduction of chemical oxygen demand (COD), colour, and total organic carbon in effluents from a slaughterhouse in central Mexico was performed using clinoptilolite-rich tuff. The experimental parameters considered were initial concentration of the adsorbate, pH, adsorbent dosage, and contact time. Surface morphology of the materials was tested by using scanning electron microscopy. Specific surface area was analysed by using Brunauer-Emmett-Teller (BET) and phase composition was analysed by using X-ray diffraction. The experimental adsorption data were fitted to the first- and pseudo-second-order kinetic models. The highest COD removal was observed in slightly acidic pH conditions. The maximum reduction efficiency of COD was accomplished with unmodified clinoptilolite-rich tuff at a contact time of 1440 min. In these conditions, the adsorbent was efficient for treating wastewater from a slaughterhouse. Moreover, after several regeneration cycles with Fenton reagent or hydrogen peroxide, the regenerated zeolite with H2O2 (3%) showed the best reduction efficiencies.