Sorption of antibiotics to biofilm

Wunder, David B.; Bosscher, Valerie; Cok, Rhiana C.; Hozalski, Raymond M.

doi:10.1016/j.watres.2010.11.013

Cited by 81 publications

(42 citation statements)

References 60 publications

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“…The high tendency of some drugs to partition to solid organic matter, similar to biofilms has been confirmed by ASE followed by LC-MS/MS analysis [30,[38][39][40]. Those hydrophobic drugs with a comparatively high log K ow (>4) (e.g., diclofenac and fluoxetine) are considered to have a tendancy to sorb to solid organic surfaces such as biofilms [82][83]. However, sorption cannot be predicted by hydrophobicity alone [83][84]; other properties such as molecular weight and ionic speciation are of known importance [83], as is the nature of other dissolved species with which they may interact [85].…”

Section: 1mentioning

confidence: 91%

“…Those hydrophobic drugs with a comparatively high log K ow (>4) (e.g., diclofenac and fluoxetine) are considered to have a tendancy to sorb to solid organic surfaces such as biofilms [82][83]. However, sorption cannot be predicted by hydrophobicity alone [83][84]; other properties such as molecular weight and ionic speciation are of known importance [83], as is the nature of other dissolved species with which they may interact [85]. Extracellular polymeric substances offer both anionic and cationic functional groups for the exchange of charged species [83].…”

Section: 1mentioning

confidence: 99%

“…However, sorption cannot be predicted by hydrophobicity alone [83][84]; other properties such as molecular weight and ionic speciation are of known importance [83], as is the nature of other dissolved species with which they may interact [85]. Extracellular polymeric substances offer both anionic and cationic functional groups for the exchange of charged species [83]. At a pH typical of municipal wastewaters (e.g., 7-8), EPS is negatively charged [83] with pKa's generally ranging from 6.2 to 10.1 [86].…”

Section: 1mentioning

confidence: 99%

“…Extracellular polymeric substances offer both anionic and cationic functional groups for the exchange of charged species [83]. At a pH typical of municipal wastewaters (e.g., 7-8), EPS is negatively charged [83] with pKa's generally ranging from 6.2 to 10.1 [86]. Those drugs whose pKa is <7 (e.g., ibuprofen, diclofenac, naproxen, ketoprofen and oxytetracyline) ( Table 1) will themselves be negatively charged and repulsion with the biofilm may restrict sorption.…”

Section: 1mentioning

confidence: 99%

“…Removal will also be influenced by biofilm porosity. Drugs whose molecular size is comparatively large (e.g., erythromycin), will have a reduced rate of mass transfer between the liquid medium and the biofilm, limiting partitioning [83]. Drugs which are comparatively smaller (<300 g mol -1 ) and relatively hydrophobic in nature (log K ow 's >3) (e.g., ibuprofen, diclofenac, naproxen, ketoprofen, propranolol and EE2, Table 1) are expected to partition well within the biofilm matrix.…”

Section: 1mentioning

confidence: 99%

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Fate of drugs during wastewater treatment

Petrie

McAdam

Scrimshaw

et al. 2013

TrAC Trends in Analytical Chemistry

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Recent trends for the determination of pharmaceutical drugs in wastewaters focus on the development of rapid multi-residue methods. These encompass a large number of drugs (up to 90) of varying physicochemical composition (hydrophobicity, molecular weight etc) at ng l -1 concentrations in the aqueous phase of complex heterogeneous matrices. These are well suited for drug determination in secondary effluents which contain detectable concentrations of pharmaceuticals. Drugs are not routinely monitored for in particulate phases of wastewaters despite being essential for fate determination, particularly in secondary processes receiving relatively high concentrations of suspended solids. Secondary effluents tend to contain multiple drugs, often above their proposed legislative targets for consent. Thus, tertiary processing may be considered to enhance drug removal and provide additional environmental protection. However, current analytical methods do not enable the efficacy of tertiary processes to be fully ascertained due to the inherently lower drug concentrations achieved. Existing method optimisation is required to lower detection capabilities for tertiary process monitoring. This would aid the understanding of breakdown reaction completeness and the criticality between parent drug and degradation product concentrations. Numerous degradation products are formed by biological and chemical processes which can exhibit toxicity. The complimentary use of biological assays here would improve understanding of the synergistic toxicological effect of multiple drugs and their degradation products at low concentration. Additionally, tertiary processes receive secondary effluents comprising comparatively high concentrations of dissolved organics (e.g., colloids). However, knowledge of drug behaviour in the charged colloidal fraction of wastewater and its impact to treatment is limited. Monitoring and understanding here is needed to develop tertiary process diagnosis and optimisation.

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Section: 1mentioning

confidence: 91%

Section: 1mentioning

confidence: 99%

Section: 1mentioning

confidence: 99%

Section: 1mentioning

confidence: 99%

Section: 1mentioning

confidence: 99%

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Fate of drugs during wastewater treatment

Petrie

McAdam

Scrimshaw

et al. 2013

TrAC Trends in Analytical Chemistry

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Vulnerability and Resilience of Estuaries to Contamination by Antibiotics and Antibiotic‐Resistant Bacteria: A Challenge for the Next Decade

Petit¹,

Berthe²,

Budzinski³

et al. 2014

Vulnerability of Coastal Ecosystems and Adaptation

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Chemical Fate and Partitioning Behavior of Antibiotics in the Aquatic Environment—A Review

Harrower

McNaughtan

Hunter

et al. 2021

Enviro Toxic and Chemistry

108

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Antibiotics (ABs) in the aquatic environment is a major problem due to the emergence of antibiotic resistance. The long-term ecological impact on the aquatic environment is unknown. Many sources allow entry of ABs into the environment, including Wastewater Treatment Plants (WWTPs), agricultural run-off, hospital effluent and landfill leachate. Concentrations of ABs in the aquatic environment vary significantly, studies have shown fluoroquinolones, tetracycline, macrolides, sulphonamides and penicillins to reach 2900, 1500, 9700, 21400 and 1600 ngL -1 in wastewater effluent samples, however, concentrations are highly variable between different countries and depend on several factors including seasonally variation, prescription, and WWTP operating procedures. Likewise, the reported concentrations that cause environmental effects varies greatly between ABs, even within the same This article is protected by copyright. All rights reserved. Accepted Articleclass, however, this predicted concentration for the ABs considered was frequently <1000 ngL -1 indicating that when discharged into the environment along with treated effluent, these have a potential detrimental effect on the environment. Antibiotics are generally quite hydrophilic in nature; however, they can ionise in the aquatic environment to form charged structures, such as cations, zwitterions, and anions.Certain classes, particularly fluoroquinolones and tetracyclines, can adsorb onto solid matrices, including soils, sediment, and sludge, making it difficult to fully understand their chemical fate in the aquatic environment. The adsorption coefficient (K d ) varies between different classes of ABs, where tetracyclines and fluoroquinolones show the highest K d values. Adsorption coefficients values for fluoroquinolones, tetracyclines, macrolides and sulphonamides have been reported as 54600, 7600, 130 and 1.37 Lkg -1 . Factors such as pH of the environment, solid matrix (sediment/soil sludge) and ionic strength can influence the K d , therefore, several values exist in literature for the same compound.

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Sorption of antibiotics to biofilm

Cited by 81 publications

References 60 publications

Fate of drugs during wastewater treatment

Fate of drugs during wastewater treatment

Vulnerability and Resilience of Estuaries to Contamination by Antibiotics and Antibiotic‐Resistant Bacteria: A Challenge for the Next Decade

Chemical Fate and Partitioning Behavior of Antibiotics in the Aquatic Environment—A Review

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