Sorption of parenteral nitrates during administration with a syringe pump and extension set

Allwood, M. C.

doi:10.1016/0378-5173(87)90215-8

Cited by 1 publication

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“…It is possible, therefore, that the initial slope of the first-order plot was due to rapid adsorption of the parent compound onto PVC followed by a slower dissolution and migration of the drugs into the plastic matrix. This sorption model has been suggested for the interaction of glyceryl trinitrate, warfarin and the benzodiazepines with PVC (13)(14)(15). Table 2 shows the percentage of each drug sorbed to 100ml PVC minibags after 192 h. The apparent partition coefficient (K) of these drugs between PVC and the solution was estimated using the following equation (13) For solutions stored in sodium chloride (0.9%; pH = 6.47) at 25"C, the log K values for doxorubicin, epirubicin and daunorubicin were 0.1, 0.2 and -0.2, respectively.…”

Section: Stability In Polyvinylchloride ( P V C ) Minibagsmentioning

confidence: 99%

STABILITY OF DOXORUBICIN, DAUNORUBICIN and EPIRUBICIN IN PLASTIC SYRINGES and MINIBAGS

1990

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The shelf lives of doxorubicin, daunorubicin and epirubicin in infusion fluids were studied using high-performance liquid chromatographic (HPLC) methods. Doxorubicin and epirubicin were stable (loss in potency of less than 10%) for 24 and 20 days respectively, when dissolved in sodium chloride solution (0.9%; pH, 6.47) at 25 degrees C and stored in polyvinyl chloride (PVC) minibags, while daunorubicin was stable for at least 43 days. All three drugs were stable for at least 43 days in sodium chloride (0.9%; pH 6.47 and 5.20) and dextrose (5%; pH 4.36) at 4 and -20 degrees C. Repeated thawing and re-freezing of these solutions at ambient temperature did not cause degradation. All three drugs were stable for at least 43 days when reconstituted with Water-for-Injections BP and stored in polypropylene syringes at 4 degrees C.

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Section: Stability In Polyvinylchloride ( P V C ) Minibagsmentioning

confidence: 99%