2011
DOI: 10.1007/978-3-642-22006-7_55
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Sorting by Transpositions Is Difficult

Abstract: Abstract.In comparative genomics, a transposition is an operation that exchanges two consecutive sequences of genes in a genome. The transposition distance, that is, the minimum number of transpositions needed to transform a genome into another, can be considered as a relevant evolutionary distance. The problem of computing this distance when genomes are represented by permutations, called the SORTING BY TRANSPOSITIONS problem (SBT), has been introduced by Bafna and Pevzner [3] in 1995. It has naturally been … Show more

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Cited by 15 publications
(4 citation statements)
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“…Recently, Bulteau et al 1 published a NP-hardness proof for this problem. Many algorithms were developed in order to¯nd a result close to the transposition distance, and most of them focused on improving the approximation factor or presenting novel data structures to the problem.…”
Section: Introductionmentioning
confidence: 98%
“…Recently, Bulteau et al 1 published a NP-hardness proof for this problem. Many algorithms were developed in order to¯nd a result close to the transposition distance, and most of them focused on improving the approximation factor or presenting novel data structures to the problem.…”
Section: Introductionmentioning
confidence: 98%
“…While the characterization does not lead to a new algorithm for computating rotation distance between two trees, we believe that it might be useful in proving NP-compeleteness of the problem, given that the problem of transforming a given permutation to identity permutation (this is called the sorting problem for permutations) with minimum number of transposition operations is known to be NP-complete [BFR11].…”
Section: Introductionmentioning
confidence: 99%
“…The problem of determining the transposition distance of permutations is NP -hard [3] and there are no tight bounds for the distance. We combine the reality and desire diagram [1] and the unitary toric classes to obtain tight bounds for the transposition distance of lonely permutations.…”
Section: Introductionmentioning
confidence: 99%
“…
One of the main operations of genome rearrangement is the transposition (exchange of contiguous blocks). Recently, the problem of computing the minimum amount of operations of transpositions needed to transform one sequence into another (transposition distance) between two permutations was proved to be N P -hard [3]. The exact distance is known for few cases.
…”
mentioning
confidence: 99%