SOS-dependent A→G transitions induced by hydroxyl radical generating system hypoxanthine/xanthine oxidase/Fe3+/EDTA are accompanied by the increase of Fapy-adenine content in M13 mp18 phage DNA

Gra̧ziewicz, Maria-Anna; Zastawny, Tomasz H.; Oliński, Ryszard; Tudek, Barbara

doi:10.1016/s0921-8777(99)00012-9

Cited by 21 publications

(21 citation statements)

References 40 publications

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“…Therefore, it can be hypothesized that the symbiotic mesophilic fungi (such as P. hepiali and/or other mesophilic fungi) may provide the essential machinery (e.g., tautomerase, methyltransferases, deaminases, xanthine oxidase, etc.) for mismatch inter-conversion and facilitate the initiation of stroma germination and the subsequent maturation processes [36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Maturational Alteration of Oppositely Orientated rDNA and Differential Proliferation of GC- and AT-biased Genotypes of Ophiocordyceps sinensis and Paecilomyces hepiali in Natural Cordyceps sinensis

Zhu¹,

Gao²,

Li³

et al. 2010

Am. J. Biomed. Sci.

165

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Multiple reports have detailed the simultaneous detection of ribosomal DNA (rDNA) of Paecilomyces hepiali (Ph), Hirsutella sinensis and two genotypes of Ophiocordyceps sinensis (Os) from Cordyceps sinensis (Cs), and the altered phenotypes and chemical components of Cs during Cs maturation. In this study, we observed an increase in the biomass of Ph and two moieties of Os rDNA during Cs maturation. The GCand AT-biased genotypes of transition mutations in the Cs stroma were confirmed using MassARRAY SNP genotyping. In premature Cs, the AT-biased genotypes were not expressed in the caterpillar, but highly predominated in the stroma. The GC bias was expressed in an opposite manner in the premature Cs compartments. The differential expression of GC-and AT-biased mutants was altered during Cs maturation. The increased biomass of the inverse-oriented Os rDNA of the GC-genotype was associated with a maturational increase in stroma height. We also report evidence of transversion mutations within Cs genes. The dynamic alterations of Ph and Os mutant gene expressions along with Cs maturation may play an essential role in Cs germination and maturation, the key elements of Cs life cycle, and result in the varied therapeutic potency of Cs.

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Section: Discussionmentioning

confidence: 99%

Maturational Alteration of Oppositely Orientated rDNA and Differential Proliferation of GC- and AT-biased Genotypes of Ophiocordyceps sinensis and Paecilomyces hepiali in Natural Cordyceps sinensis

Zhu¹,

Gao²,

Li³

et al. 2010

Am. J. Biomed. Sci.

165

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show abstract

“…ROS induces a wide spectrum of mutations in mammalian cells [63][64][65][66], some of which have been related to specific oxidized bases. For example, 8-hydroxyguanine is chiefly associated with G to T mutations [67] whereas 2-hydroxyadenine and FapyAde are associated with A to G and A to T mutations [68,69]. The overwhelming abundance of A·T to G·C transitions in the pre-existing spectra does not permit an easy correlation of these mutations with oxidative DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Induction of A·T to G·C mutations by erroneous repair of depurinated DNA following estrogen treatment of the mammary gland of ACI rats

Mailander

Meza

Higginbotham

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

117

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“…ROS oxidize both the sugar and base components of DNA, causing a variety of adducts as well as abasic sites and single-and double-stranded breaks (1,9). Such premutagenic oxidative lesions to DNA, if left unrepaired, have been shown to cause point mutations and frameshift mutations (20).…”

Section: Discussionmentioning

confidence: 99%

POS5 Gene of Saccharomyces cerevisiae Encodes a Mitochondrial NADH Kinase Required for Stability of Mitochondrial DNA

et al. 2003

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In a search for nuclear genes that affect mutagenesis of mitochondrial DNA in Saccharomyces cerevisiae, an ATP-NAD (NADH) kinase, encoded by POS5, that functions exclusively in mitochondria was identified. The POS5 gene product was overproduced in Escherichia coli and purified without a mitochondrial targeting sequence. A direct biochemical assay demonstrated that the POS5 gene product utilizes ATP to phosphorylate both NADH and NAD ؉ , with a twofold preference for NADH. Disruption of POS5 increased minus-one frameshift mutations in mitochondrial DNA 50-fold, as measured by the arg8 m reversion assay, with no increase in nuclear mutations. Also, a dramatic increase in petite colony formation and slow growth on glycerol or limited glucose were observed. POS5 was previously described as a gene required for resistance to hydrogen peroxide. Consistent with a role in the mitochondrial response to oxidative stress, a pos5 deletion exhibited a 28-fold increase in oxidative damage to mitochondrial proteins and hypersensitivity to exogenous copper. Furthermore, disruption of POS5 induced mitochondrial biogenesis as a response to mitochondrial dysfunction. Thus, the POS5 NADH kinase is required for mitochondrial DNA stability with a critical role in detoxification of reactive oxygen species. These results predict a role for NADH kinase in human mitochondrial diseases.

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SOS-dependent A→G transitions induced by hydroxyl radical generating system hypoxanthine/xanthine oxidase/Fe3+/EDTA are accompanied by the increase of Fapy-adenine content in M13 mp18 phage DNA

Cited by 21 publications

References 40 publications

Maturational Alteration of Oppositely Orientated rDNA and Differential Proliferation of GC- and AT-biased Genotypes of Ophiocordyceps sinensis and Paecilomyces hepiali in Natural Cordyceps sinensis

Maturational Alteration of Oppositely Orientated rDNA and Differential Proliferation of GC- and AT-biased Genotypes of Ophiocordyceps sinensis and Paecilomyces hepiali in Natural Cordyceps sinensis

Induction of A·T to G·C mutations by erroneous repair of depurinated DNA following estrogen treatment of the mammary gland of ACI rats

POS5 Gene of Saccharomyces cerevisiae Encodes a Mitochondrial NADH Kinase Required for Stability of Mitochondrial DNA

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