Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response

Jin, Seong Chul; Kim, Mi Hye; Jo, Si Yeon; Choi, La Yoon; Lee, Haesu; Yang, Woong Mο

doi:10.1007/s11418-020-01421-w

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Previously, a potential of SST has been reported as anti-inflammatory medication in various diseases such as asthma, atopic dermatitis and liver injury. 6 , 7 , 8 These reports may support to address the main mechanisms thereby protecting neuronal damages by the SST treatment through activation of the proinflammation-related signaling pathways.…”

Section: Discussionmentioning

confidence: 77%

“…SST was traditionally used to control febrile diseases in several Asian countries. 1 Recent studies support the notion that SST has potential anti-tumor, 2 , 3 , 4 , 5 anti-inflammatory, 6 , 7 , 8 immune regulatory, 9 , 10 and hepatoprotective 5 , 7 activities in preclinical investigations. Most clinical studies using SST have shown its efficacy for liver problems such as hepatic dysfunction, 11 chronic liver diseases, 12 hepatitis B and C, 13 , 14 and liver cancer.…”

Section: Introductionmentioning

confidence: 84%

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Korean traditional herbal formula Soshiho-tang attenuates memory impairment and neuronal damage in mice with amyloid-beta-induced Alzheimer's disease

Sohn

Kim

Jeong

2021

Integrative Medicine Research

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Background Soshiho-tang (SST), also known as Xiaochaihu-tang in China and Sho-saiko-to in Japan, is an Oriental herbal formula traditionally used to treat febrile diseases. Recently, several in vitro and in vivo studies have reported the anti-cancer, anti-liver disease, and anti-inflammatory activities of SST. However, there is little evidence of its effects on neurological diseases. We previously reported the inhibitory effects of SST on in vitro acetylcholinesterase (AChE) activation and amyloid-β (Aβ) aggregation, which are crucial hallmarks of Alzheimer's disease (AD). In the present study, we report that SST has preventive effects on memory impairment and neuronal cell changes in an Aβ-induced AD-like mouse model. Methods Male mice underwent injection of Aβ aggregates and administered SST (500, 1,000, or 2,000 mg/kg/day) for 20 days. Behavioral tests (passive avoidance task [PAT] and Morris water maze [MWM] test) were conducted. Lastly, brain sections were obtained from sacrificed mice for quantitative analysis. Results Intracerebroventricular (ICV) injection of Aβ aggregates significantly decreased the latency time in the PAT and MWM test compared to normal control. In contrast, SST administration markedly reversed the latency caused by Aβ injection. Additionally, our data revealed that SST-mediated improvements in memory impairment are related to its neuroprotective and anti-neuroinflammatory effects. On histological analysis, SST treatment protected neuronal loss and damage as well as microglial activation, and ameliorated amount of Aβ in brain of mouse model of AD. Conclusion Our findings suggest that SST may be a promising candidate for the development of novel drugs for AD.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 84%

Korean traditional herbal formula Soshiho-tang attenuates memory impairment and neuronal damage in mice with amyloid-beta-induced Alzheimer's disease

Sohn

Kim

Jeong

2021

Integrative Medicine Research

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“…30 Previous investigations have reported that Shosaikoto has potential application as an anti-inflammatory drug by inhibiting proinflammatory cytokines and promoting endogenous enhancement of steroid secretion. 18,31 Therefore, Saireito has both antiinflammatory and water utilization benefits.…”

Section: Byakujutsu Saireitomentioning

confidence: 99%

The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: A Prospective Randomized Study

Matsumoto,

Miyata

et al. 2023

Neurosurgery

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BACKGROUND AND OBJECTIVES: Chronic subdural hematoma (CSDH) sometimes recurs after surgical treatment and requires reoperation. In Japan, Japanese herbal medicines (Kampo), such as Goreisan and Saireito, have been used as adjunctive therapies to prevent the recurrence of CSDH. However, no prospective randomized study has proven the efficacy of Kampo medicine in all patients. To investigate whether Goreisan and Saireito reduce the postoperative recurrence of CSDH in a prospective randomized study. METHODS: Between April 2017 and July 2019, a total of 118 patients who underwent initial burr hole surgery for CSDH were randomly assigned to the following 3 groups: (1) Goreisan for 3 months (Group G), (2) Saireito for 3 months (Group S), and (3) no medication (Group N). The primary end point was symptomatic recurrence within 3 months postoperatively, and the secondary end point was complications associated with the administration of Kampo medicine. RESULTS: Among 118 patients, 114 (Group N, n = 39; Group G, n = 37; and Group S, n = 38) were included in our analysis. In this study, byakujutsu (containing Atractylodes rhizome) Goreisan and Saireito were used, unlike other prospective randomized studies in which sojutsu (containing Atractylodes lancea rhizome) Goreisan was used. The overall recurrence rate was 11.4% (13/114: 10 for Group N, 2 for Group G, and 1 for Group S). The recurrence rate of Group G was significantly lower than that of Group N (5.4% vs 25.6%; P = .043). The recurrence rate of Group S was also significantly lower than that of Group N (2.6% vs 25.6%; P = .02). No patients developed complications associated with the administration of Kampo medicine. CONCLUSION: This is the first study to show that Kampo medicine reduced the recurrence rate of CSDH in an overall population. This study demonstrated that byakujutsu Goreisan and Saireito may have favorable effects, unlike other studies, because byakujutsu has stronger anti-inflammatory activity than sojutsu.

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Protective effects of paeonol against lipopolysaccharide-induced liver oxidative stress and inflammation in gibel carp (Carassius auratus gibelio)

Chen

et al. 2022

Comparative Biochemistry and Physiology Part C: Toxicology &

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Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response

Cited by 5 publications

References 36 publications

Korean traditional herbal formula Soshiho-tang attenuates memory impairment and neuronal damage in mice with amyloid-beta-induced Alzheimer's disease

Korean traditional herbal formula Soshiho-tang attenuates memory impairment and neuronal damage in mice with amyloid-beta-induced Alzheimer's disease

The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: A Prospective Randomized Study

Protective effects of paeonol against lipopolysaccharide-induced liver oxidative stress and inflammation in gibel carp (Carassius auratus gibelio)

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