Soshiho-tang water extract inhibits ovalbumin-induced airway inflammation via the regulation of heme oxygenase-1

Abstract

BackgroundSoshiho-tang, known as Xio-hai-Hu-Tang in Chinese and Sho-Saiko-to in Japanese, has been widely used as a therapeutic agent. Its pharmacological effects include anti-inflammatory, antioxidant, antihepatic fibrosis, antitumor and immunomodulating activities. However, little is known regarding its effects on allergic asthma. Therefore, the aim of the present study was to investigate whether the Soshiho-tang water extract (SSTW) has antiasthmatic effects on airway inflammation in an ovalbumin (OVA)-induced mouse model.MethodsBALB/c mice were used as a model of asthma after induction by sensitization and challenge with OVA. We measured change in eosinophils, other inflammatory cells, and T helper 2 (Th2)-type cytokines, such as interleukin (IL)-4, IL-5, IL-13, IL-17, IL-33, and chemokine (eotaxin) in bronchoalveolar lavage fluid (BALF), presence of total and OVA-specific immunoglobulin (Ig)E in plasma, and expression of mucus production and heme oxygenase (HO)-1 protein in lung tissue.ResultsOur results show that SSTW had a suppressive effect on eosinophil influx into BALF and decreased the levels of Th2-type cytokines. Moreover, SSTW exhibited a marked decrease in mucus hypersecretion, total and OVA-specific IgE levels, and significantly induced HO-1 protein expression.ConclusionsThese results suggest that SSTW may be used as a valuable therapeutic agent for treating various inflammatory diseases including allergic asthma.

Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators

“…HO-1 has been shown to attenuate symptoms in AD-like lesions mice model (Kirino et al, 2008). Recent studies have shown that SST highly increases HO-1 protein expression (Jeon et al, 2015). In the present study, we also observed that SST increased HO-1 protein expression.…”

“…To date, several pharmacological activities of SST have been reported. According to previous experimental studies, this herbal prescription effects treatment of chronic hepatitis (Kusunose et al, 2002) and liver cirrhosis (Chen et al, 2004; Chen et al, 2005) and exhibits a variety of pharmacological properties including anti-inflammatory (Amagaya et al, 1986; Oh et al, 2013), antioxidant (Sakaguchi et al, 1993), anti-tumor (Zhu et al, 2005), anti-obesity (Yoo et al, 2016), anti-asthmatic (Jeon et al, 2015), and immune-regulative activities (Taira et al, 2004; Kang et al, 2009). In addition, SST showed no significant variation between contents depending on the storage period.…”

Korean traditional herbal formula Soshiho-tang attenuates memory impairment and neuronal damage in mice with amyloid-beta-induced Alzheimer's disease

“…SST was traditionally used to control febrile diseases in several Asian countries. 1 Recent studies support the notion that SST has potential anti-tumor, 2 , 3 , 4 , 5 anti-inflammatory, 6 , 7 , 8 immune regulatory, 9 , 10 and hepatoprotective 5 , 7 activities in preclinical investigations. Most clinical studies using SST have shown its efficacy for liver problems such as hepatic dysfunction, 11 chronic liver diseases, 12 hepatitis B and C, 13 , 14 and liver cancer.…”

Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications

“…To date, a variety of HO-1 activator can be extracted from Saururus chinensis [ 54 , 55 ], Phytolacca esculenta [ 68 ], Garlic [ 40 ], and soshiho-tang [ 73 ]. Among them, diallyl-disulfide (isolated from Garlic ) [ 40 ] and esculentoside A (isolated from Phytolacca esculenta ) [ 68 ] have been further proved as Nrf-2 activators.…”