Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling

Ge, Sitang; Yang, Yanling; Zuo, Lugen; Xue, Song; Wen, Hexin; Geng, Zhijun; He, Yifan; Xu, Zhenzhen; Wu, Huayue; Shen, Mengdi; Ge, Yuanyuan; Sun, Xuejun

doi:10.1016/j.ejphar.2022.175464

Cited by 7 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…M1 polarization may be accompanied by the breakdown of the intestinal barrier and thereby lead to inflammatory progression of the intestine, while M2 polarization is usually associated with an elevation of tissue repair activity and remission of gut inflammation. For example, a study by Ge et al (2023) reported that inhibition of M1 macrophage using Sotetsuflavone, a natural flavonoid derived from many herbal plants, may be beneficial to the restoration of the intestinal barrier in IBD.…”

Section: Intestinal Barrier Plays a Critical Role In Maintaining Gut ...mentioning

confidence: 99%

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

Xu,

Yao,

Liu

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Ulcerative colitis (UC) is an idiopathic inflammatory disease mainly affects the large bowel and the rectum. The pathogenesis of this disease has not been fully elucidated, while the disruption of the intestinal barrier function triggered by various stimulating factors related to the host genetics, immunity, gut microbiota, and environment has been considered to be major mechanisms that affect the development of UC. Given the limited effective therapies, the treatment of this disease is not ideal and its incidence and prevalence are increasing. Therefore, developing new therapies with high efficiency and efficacy is important for treating UC. Many recent studies disclosed that numerous herbal decoctions and natural compounds derived from traditional herbal medicine showed promising therapeutic activities in animal models of colitis and have gained increasing attention from scientists in the study of UC. Some of these decoctions and compounds can effectively alleviate colonic inflammation and relieve clinical symptoms in animal models of colitis via regulating intestinal barrier function. While no study is available to review the underlying mechanisms of these potential therapies in regulating the integrity and function of the intestinal barrier. This review aims to summarize the effects of various herbal decoctions or bioactive compounds on the severity of colonic inflammation via various mechanisms, mainly including regulating the production of tight junction proteins, mucins, the composition of gut microbiota and microbial-associated metabolites, the infiltration of inflammatory cells and mediators, and the oxidative stress in the gut. On this basis, we discussed the related regulators and the affected signaling pathways of the mentioned traditional medicine in modulating the disruption or restoration of the intestinal barrier, such as NF-κB/MAPK, PI3K, and HIF-1α signaling pathways. In addition, the possible limitations of current studies and a prospect for future investigation and development of new UC therapies are provided based on our knowledge and current understanding. This review may improve our understanding of the current progression in studies of traditional medicine-derived therapies in protecting the intestinal barrier function and their roles in alleviating animal models of UC. It may be beneficial to the work of researchers in both basic and translational studies of UC.

show abstract

Section: Intestinal Barrier Plays a Critical Role In Maintaining Gut ...mentioning

confidence: 99%

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

Xu,

Yao,

Liu

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…According to reports, Sotetsuflavone has antibacterial, anticancer, anti-inflammatory and antiviral effects [12][13][14]. It is noteworthy that Sotetsuflavone can inhibit the invasion and metastasis of non-small cell lung cancer A549 cells by reversing EMT through TNF-α/NF-κB and PI3K/AKT signalling pathways [15], and also enhances the inhibitory effect of 5fluorouracil on gastric cancer cells through the AKT-mTOR pathway [16].…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology, single gene survival analysis and molecular docking to study the mechanism of Sotetsuflavone in the treatment of pancreatic cancer

Chu,

2024

Preprint

View full text Add to dashboard Cite

Pancreatic cancer is a highly lethal cancer with limited treatment options. The number of pancreatic cancer patients is increasing rapidly worldwide. Many natural products have been shown to have anticancer activity in a range of studies. Sotetsuflavone is derived from Cycas revoluta Thunb. and exhibits anticancer activity. The present study incorporates network pharmacology, single gene survival analysis, gene expression analysis and molecular docking to reveal the mechanism of Sotetsuflavone in the treatment of pancreatic cancer. Initially, it was evaluated through multiple databases for a comprehensive pharmacological evaluation of Sotetsuflavone. Then, the target information of Sotetsuflavone and pancreatic cancer was searched and screened using public databases. According to the results of matching the potential targets of Sotetsuflavone with the targets of pancreatic cancer, the protein-protein interaction (PPI) network was constructed by using the STRING database and imported into Cytoscape 3.9.0 for the network analysis to screen the hub targets, and then classify and co-expression analysis was carried out on the hub targets. Then, we conducted Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of potential and hub targets and discovered that these targets were involved in pancreatic cancer-related signalling pathways. In addition, the GEPIA 2 platform was used to be performed for single gene survival analysis and gene expression analysis, and AutoDock Vina was employed for molecular docking analysis. In total, we have acquired 31 hub targets for the treatment of pancreatic cancer by Sotetsuflavone, namely ABCB1, AURKA, CDK1, and so on. Kaplan-Meier survival analyses demonstrated that ABCB1, AURKA, CDK1, HDAC6, MET, and MMP3 are promising hub targets that can be used as biomarkers for pancreatic cancer diagnosis and prognosis. These hub targets are highly expressed in pancreatic cancer tissues compared to normal tissues. The molecular docking results showed a strong binding capacity of Sotetsuflavone to these hub targets. In summary, it is proposed that Sotetsuflavone is a new anticancer drug, which can regulate cancer-related signalling pathways such as pancreatic cancer by inhibiting the activities of ABCB1, AURKA, CDK1, HDAC6, MET, and MMP3, which are hub targets with up-regulated expression in pancreatic cancer tissues, in order to treat pancreatic cancer. However, it also requires a series of in vivo and in vitro studies to ensure its safety and efficacy.

show abstract

The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis

Song,

Zhang,

Zhang

et al. 2024

Chemico-Biological Interactions

View full text Add to dashboard Cite

Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling

Cited by 7 publications

References 42 publications

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

Network pharmacology, single gene survival analysis and molecular docking to study the mechanism of Sotetsuflavone in the treatment of pancreatic cancer

The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis

Contact Info

Product

Resources

About