Sotos syndrome.

Abstract

S otos syndrome is a congenital overgrowth disorder associated with medical, educational, and social-emotional effects. The overgrowth in particular is associated with advanced bone age, macrocephaly (i.e., head circumference that measures two standard deviations larger than the average for the given sex and age), distinctive craniofacial features (e.g., high-bossed forehead; prominent narrow jaw; long, narrow face), and intellectual disability (Albores-Gallo et al.