The Federal Aviation Administration’s vision for the Next Generation Air Transportation System (NextGen) includes the implementation of advanced automation capabilities to deliver operational benefits. As these new systems have been deployed, some inefficiencies in the systems engineering process have been noted and attributed to the failure to adequately consider human systems integration in the engineering process (GAO, 2010). Human systems integration can be improved through the definition of quantitative requirements, which ensure that systems are designed effectively and validated fully prior to implementation. This paper provides an overview of a process used to define quantitative guidelines for human systems integration and the application of that process to a set of guidelines for supporting the perception of visual and auditory displays.