Sound-induced modulation of hippocampal θ oscillations

Abe, Reimi; Sakaguchi, Tetsuya; Kitajo, Keiichi; Ishikawa, Daisuke; Matsumoto, Nobuyoshi; Matsuki, Norio; Ikegaya, Yuji

doi:10.1097/wnr.0000000000000274

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…The animal wakefulness was important for the recorded neurons responding to broadband noise as well as their spontaneous activities (Figure 1 ), despite the small sample size ( n = 8). It is similar as previous results (Abe et al, 2014a , b ) that neuronal acoustic responses were largely reduced and even abolished for a short time by general anesthesia. However, anesthetized hippocampal acoustic responses have been reported in many studies (Miller and Freedman, 1995 ; Ruusuvirta et al, 1995a , b , 2013 , 2015 ; Krause et al, 2003 ; Dissanayake et al, 2008 , 2009 ).…”

Section: Discussionsupporting

confidence: 93%

“…We also found that both the latency and peak amplitude of the noise-induced excitatory and inhibitory inputs to an awake CA3 neuron changed synchronously along with the sound levels (Figures 4B–D , 5 ). However, the unbalanced, only inhibitory inputs evoked by pure tones via fimbria-fornix pathway were reported on CA1 neurons recently (Abe et al, 2014a ) while we found CA3 neurons had poor responses to tones in this study (Figures 2A,B ). Since the information flows from CA3 to CA1 directly or via the EC (Deadwyler et al, 1975 ; Finch et al, 1986 ; Buzsaki, 1989 ; Sik et al, 1994 ; Tamamaki and Nojyo, 1995 ; Hongo et al, 2015 ), neural circuits, including hippocampus and EC and even more, might play an important role in the difference of the acoustic evoked inputs in CA3 and CA1.…”

Section: Discussioncontrasting

confidence: 53%

“…We adopted in vivo loose-patch recordings to reveal the basic features of the CA3 neurons responding to acoustic stimuli in awake, head-fixed animals. Although, the balance between excitation and inhibition appears to be a common feature of neural circuits in a variety of sensory systems (Okun and Lampl, 2008 ; Xue et al, 2014 ; Zhou et al, 2014 ; Large et al, 2016 ), Abe et al ( 2014a ) showed that tone bursts only evoked transient increase of inhibitory post-synaptic conductance in awake CA1 neurons. Since the information flow routes exist mainly from CA3 to CA1 (Deadwyler et al, 1975 ; Hongo et al, 2015 ), we attempted to reveal the relationship between the acoustic evoked excitation and inhibition on CA3 neurons by using in vivo whole-cell recording techniques and analyzing the changes of their peak amplitude and latency along with stimulation intensity.…”

Section: Introductionmentioning

confidence: 99%

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Balanced Noise-Evoked Excitation and Inhibition in Awake Mice CA3

et al. 2017

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The hippocampus is known as a neuronal structure involved in learning, memory and spatial navigation using multi-sensory cues. However, the basic features of its response to acoustic stimuli without any behavioral tasks (conditioning) remains poorly studied. Here, we investigated the CA3 response to auditory stimuli using in vivo loose-patch recordings in awake and anesthetized C57 mice. Different acoustic stimuli in addition to broadband noise such as click, FM sound and pure tone were applied to test the response of CA3 in awake animals. It was found that the wakefulness of the animal is important for the recorded neurons to respond. The CA3 neurons showed a stronger response to broadband noise rather than the other type of stimuli which suggested that auditory information arrived at CA3 via broadband pathways. Finally, we investigated the excitatory and inhibitory inputs to CA3 neurons by using in vivo whole-cell voltage-clamp techniques with the membrane potential holding at −70 and 0 mV, respectively. In awake animals, the excitatory and inhibitory inputs CA3 neurons receive induced by noise are balanced by showing stable intervals and proportional changes of their latencies and peak amplitudes as a function of the stimulation intensities.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

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Balanced Noise-Evoked Excitation and Inhibition in Awake Mice CA3

et al. 2017

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“…In particular, any salient stimulus should be able to evoke these hippocampal responses, regardless of whether the task is hippocampally dependent (Berger et al, 1983; Moita et al, 2003; Abe et al, 2014). The salience of the stimulus, and hence its ability to trigger alertness, may change as the subject learns the predictive power of the stimulus, producing a stereotyped evolution of hippocampal activity across learning (McEchron and Disterhoft, 1997).…”

Section: Discussionmentioning

confidence: 99%

Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task

Shan

Lubenov

Παπαδοπούλου

et al. 2016

eLife

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The hippocampus is a brain area crucial for episodic memory in humans. In contrast, studies in rodents have highlighted its role in spatial learning, supported by the discovery of place cells. Efforts to reconcile these views have found neurons in the rodent hippocampus that respond to non-spatial events but have not unequivocally dissociated the spatial and non-spatial influences on these cells. To disentangle these influences, we trained freely moving rats in trace eyeblink conditioning, a hippocampally dependent task in which the animal learns to blink in response to a tone. We show that dorsal CA1 pyramidal neurons are all place cells, and do not respond to the tone when the animal is moving. When the animal is inactive, the apparent tone-evoked responses reflect an arousal-mediated resumption of place-specific firing. These results suggest that one of the main output stages of the hippocampus transmits only spatial information, even in this non-spatial task.DOI: http://dx.doi.org/10.7554/eLife.14321.001

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“…For voltage-clamp recordings, the intrapipette solution consisted of the following (in m m ): 130 CsMeSO 4 , 4 tetraethylammonium-Cl, 10 Hepes, 10 Na 2 -phosphocreatine, 0.5 EGTA, 4 MgATP, 0.3 Na 2 GTP, 2 QX-314, and 0.2% biocytin, all adjusted to pH 7.3. Because the ionic composition of extracellular fluid in the brain is similar to that of aCSF, excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs, respectively) were dominant at clamped voltages of –74 and 0 mV, respectively (Abe et al, 2014). Based on the assumptions that leak currents were blocked by intracellular cesium ions and that the equilibrium potentials for EPSCs and IPSCs were 0 and –74 mV, the excitatory and inhibitory conductance at any given point in time was estimated as G e = EPSC/(–74) and G i = IPSC/74.…”

Section: Methodsmentioning

confidence: 99%

Flashing Lights Induce Prolonged Distortions in Visual Cortical Responses and Visual Perception

Minamisawa

Funayama

Matsumoto

et al. 2017

eNeuro

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The primary sensory neocortex generates an internal representation of the environment, and its circuit reorganization is thought to lead to a modification of sensory perception. This reorganization occurs primarily through activity-dependent plasticity and has been well documented in animals during early developmental stages. Here, we describe a new method for the noninvasive induction of long-term plasticity in the mature brain: simple transient visual stimuli (i.e., flashing lights) can be used to induce prolonged modifications in visual cortical processing and visually driven behaviors. Our previous studies have shown that, in the primary visual cortex (V1) of mice, a flashing light stimulus evokes a long-delayed response that persists for seconds. When the mice were repetitively presented with drifting grating stimuli (conditioned stimuli) during the flash stimulus–evoked delayed response period, the V1 neurons exhibited a long-lasting decrease in responsiveness to the conditioned stimuli. The flash stimulus–induced underrepresentation of the grating motion was specific to the direction of the conditioned stimuli and was associated with a decrease in the animal’s ability to detect the motion of the drifting gratings. The neurophysiological and behavioral plasticity both persisted for at least several hours and required N-methyl-d-aspartate receptor activation in the visual cortex. We propose that flashing light stimuli can be used as an experimental tool to investigate the visual function and plasticity of neuronal representations and perception after a critical period of neocortical plasticity.

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Sound-induced modulation of hippocampal θ oscillations

Cited by 9 publications

References 31 publications

Balanced Noise-Evoked Excitation and Inhibition in Awake Mice CA3

Balanced Noise-Evoked Excitation and Inhibition in Awake Mice CA3

Spatial tuning and brain state account for dorsal hippocampal CA1 activity in a non-spatial learning task

Flashing Lights Induce Prolonged Distortions in Visual Cortical Responses and Visual Perception

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