Source and Route of Microbial Colonisation of Parenteral Nutrition Catheters

Cicco, Marcello De; Chiaradia, V.; Veronesi, Andrea; Santini, Gianfranco; Panarello, G.; Fracasso, A; Testa, Vinicio; Tesio, Franco

doi:10.1016/s0140-6736(89)91861-8

Cited by 95 publications

(30 citation statements)

References 14 publications

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“…Our findings also support the theory of intra-luminal infections as a major complication of non-tunnelled, central venous catheters in oncological patients [10,12,17,26]. Extended hospitalisation and delay in administration of further antineoplastic chemotherapy is often observed as well as pulmonary complications requiring a prolonged course of antibiotic treatment, leading to an increased risk of fungal infection [33].…”

Section: Fig 3 Catheter Colonisationsupporting

confidence: 85%

Chlorhexidine and silver-sulfadiazine coated central venous catheters in haematological patients—a double-blind, randomised, prospective, controlled trial

Ostendorf

Meinhold

Harter

et al. 2005

Support Care Cancer

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Section: Fig 3 Catheter Colonisationsupporting

confidence: 85%

Chlorhexidine and silver-sulfadiazine coated central venous catheters in haematological patients—a double-blind, randomised, prospective, controlled trial

Ostendorf

Meinhold

Harter

et al. 2005

Support Care Cancer

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“…Intravascular catheters may become directly infected at the hub site during insertion or manipulation (618)(619)(620), with the subsequent complication of central line-associated bloodstream infection (CLABSI). The reported incidence of CLABSI ranges from 1.3 to 6.8 events per 1,000 device-days (621-624).…”

Section: Intravascular Catheter Infectionsmentioning

confidence: 99%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…The bacterial species found on the catheter tips corresponded more frequently to those found in the stopcocks than to those found on the skin. De Cicco et al [27] observed that 45% of infected CVC tips harboured the same bacterial species as were found in the stopcocks. Infection in the patients with contaminated stopcocks was more frequently due to several species and genotypes than in patients with uncontaminated stopcocks h2 = 18.3, p = 0.001) (Tables 1-4).…”

Section: Discussionmentioning

confidence: 84%

Use of semi-quantitative and quantitative culture methods and typing for studying the epidemiology of central venous catheter-related infections in neonates on parenteral nutrition

Mueller‐Premru¹,

Gubina²,

Kaufmann

et al. 1999

Journal of Medical Microbiology

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To study the epidemiology -especially the impact of contaminated stopcocks -on central venous catheter (CVC) infection and catheter-related sepsis (CRS), semiquantitative (SQ) and quantitative (Q) culture methods and typing of coagulase-negative staphylococci (CNS) were employed in 49 neonates with clinical signs of sepsis while receiving parenteral nutrition in the paediatric intensive care unit. The patients were divided into two groups according to stopcock contamination: group A consisted of 18 patients (36%) with contaminated stopcocks and group B consisted of 31 patients (64%) with sterile stopcocks. Five specimens were obtained from each patient, in addition to that from the stopcock: a swab taken from the skin surrounding the catheter puncture site; the CVC tip; the intradermal segment (IDC); and samples of parenteral fluid and blood. A total of 294 specimens (392 sites) was cultured and micro-organisms were identified. All CNS isolated were typed by biotyping, antibiogram, plasmid analysis and pulsed-field gel electrophoresis (PFGE), and the discriminatory power of the typing methods was compared. The CVC tips were infected in 25 patients (51%); 15 (83%) in group A and 10 (32%) in group B. Sepsis was detected in 24 neonates (@YO), 13 in group A and 11 in group B. This was catheter-related in 15 patients (63%), 12 in group A and 3 in group B. CNS were recovered from 13 (52%) of 25 infected CVCs, nine in group A and four in group B. Sixty-five CNS isolates were recovered from these patients and belonged to 14 biotypes, 22 antibiograms, 22 plasmid profiles and 26 PFGE types. Typing showed that in six of nine patients in group A, CNS of the same type were recovered from the catheter tip and the stopcock, in one patient the catheter tip and skin isolates were the same and in two others the catheter tip isolates were different from stopcock and skin isolates. In all four patients in group B, different CNS types were recovered from CVC tips and skin. Bacteraemia was caused by CNS in 14 patients (58%), six in group A and eight in group B. v p i n g confirmed that nine cases (six in group A and three in group B) were catheter-related but five were not. SQ and Q culture methods and typing, especially by PFGE, allowed the study to determine that bacteria from contaminated stopcocks were frequently the source of CVC infection and CRS.

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Source and Route of Microbial Colonisation of Parenteral Nutrition Catheters

Cited by 95 publications

References 14 publications

Chlorhexidine and silver-sulfadiazine coated central venous catheters in haematological patients—a double-blind, randomised, prospective, controlled trial

Chlorhexidine and silver-sulfadiazine coated central venous catheters in haematological patients—a double-blind, randomised, prospective, controlled trial

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Use of semi-quantitative and quantitative culture methods and typing for studying the epidemiology of central venous catheter-related infections in neonates on parenteral nutrition

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