Quartz-vein type gold mineralization at Xishimen is a recently discovered gold deposit in the central North China Craton. More than 50 auriferous quartz veins occur in this region within a NNW-SSE-trending fault zone 4600 m in length and 3-10 m wide. Wall rocks are mainly Precambrian tonalite-trondhjemite-granodiorite (TTG) gneisses and associated supracrustals, modified by K-feldspathization and pyrite-phyllic hydrothermal alteration. Based on detailed field and petrographic studies, we identify five episodes of mineralization: pyrite-phyllic stage (I), coarse-grained pyrite-milky white quartz stage (II), fine-grained smoky grey quartz-pyrite stage (III), fine-grained smoky grey quartz-polymetallic sulphide stage (IV), and quartz-carbonate stage (V). We present results of δ 34 S analysis of sulphide minerals from the different stages which show tightly clustered values in the range of -1.0‰ to 2.1‰, close to those of mantle and meteorite sulphur. Lead isotopic ratios of pyrite from the early to main stages also show restricted ranges with 206 Pb/ 204 Pb of 16.289-17.286, 207 Pb/ 204 Pb of 15.217-15.453, 208 Pb/ 204 Pb of 37.012-38.232, implying lower crustal input. 3 He/ 4 He and 40 Ar/ 36 Ar ratios of fluid trapped in pyrite are 0.68 Ra to 1.20 Ra (where Ra is the 3 He/ 4He ratio of air = 1.4 × 10 −6 ) and 540.9-1065, respectively. 3 He and 4 Ar concentrations vary from 10.05 to 18.5 (10 −7 cm 3 STP/g) and 6.15 to 17.4 (10 −7 cm 3 STP/g), respectively, with calculated mantle helium ranging from 8.47% to 14.96% (average 11.01%). δ 18 O Q and δ 18 D Q values of quartz range from 8.0‰ to 13.2‰ and -101.9‰ to -70.5‰, respectively, with calculated δ 18 O W values of the mineralizing fluid ranging from 1.11‰ to 5.72‰, suggesting the mixing of magmatic aqueous fluid with meteoric water during gold precipitation. We correlate the mixed crust-mantle signature of the ore-forming sources to magmatism and metallogeny associated with Mesozoic inhomogeneous lithosphere thinning in the central North China Craton.