“…Tetrodotoxin (TTX) is a voltage-gated sodium channel blocker and is one of the bestknown and well-studied marine natural toxins [12]. The representative vector of TTX are pufferfishes (globefishes), and there have been many cases of human intoxication (some fatal), especially in East and Southeast Asia [13,14]. TTX has been found in various marine animals, including goby, blue-ringed octopus, and xanthid crabs.…”