Source monitoring for actions in adolescents with 22q11.2 deletion syndrome (22q11DS)

Debbané, Martin; Linden, Martial Van der; Glaser, Bronwyn; Eliez, Stéphan

doi:10.1017/s003329170700222x

Cited by 24 publications

(23 citation statements)

References 46 publications

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“…We suggest that an impaired shift perspective and/or episodic memory dysfunctions might alter self-other distinction in hallucination-prone subjects. Consequently, the lack of reliable representations of the actions performed by others could account for SM action impairments previously observed by Larøi et al (2005) and Debbane et al (2008). Our results also argue in favor of a decreased salience toward others in the 22q11.2DS, as illustrated by the decreased activations in regions sustaining social cognition and episodic memory.…”

Section: Discussionmentioning

confidence: 97%

“…These two studies (Larøi et al, 2005; Debbane et al, 2008) highlight the impairments in offline SM for actions in two populations with hallucination-proneness. Their results might come from disturbances in how information is encoded between first-person perspective (1PP) and 3PP.…”

Section: Introductionmentioning

confidence: 96%

“…A subsequent study employed a similar action-monitoring paradigm with adolescents affected by a 22q11.2 deletion syndrome (22q11.2DS) (Debbane et al, 2008). 22q11.2DS is a neurogenetic disorder with an ultra-high risk for developing schizophrenia (Murphy et al, 1999; Karayiorgou et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Action simulation in hallucination-prone adolescents

Dahoun

Eliez

Chen

et al. 2013

Front. Hum. Neurosci.

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Theoretical and empirical accounts suggest that impairments in self-other discrimination processes are likely to promote the expression of hallucinations. Studies using a variety of paradigms involving self-performed actions argue in favor of perspective taking confusion in hallucination-prone subjects. However, our understanding of such processes during adolescence is still at an early stage. The present study thus aims (1) to delineate the neural correlates sustaining mental simulation of actions involving self-performed actions (first-person perspective; 1PP) and other-performed actions (third-person perspective; 3PP) during adolescence (2) to identify atypical activation patterns during 1PP/3PP mental simulation of actions in hallucination-prone adolescents (3) to examine whether differential risk for schizophrenia (clinical vs. genetic) is also associated with differential impairments in the 1PP/3PP mental simulation of actions during adolescence. Twenty-two typically developing controls (Control group; 6 females), 12 hallucination-prone adolescents [auditory hallucination (AH) group; 7 females] and 13 adolescents with 22q11.2 Deletion Syndrome (22q11.2DS group; 4 females) were included in the study. During the fMRI task, subjects were presented with a cue (self-other priming cues) indicating to perform the task using either a first person perspective (“you”-1PP) or a third person perspective (“best friend”-3PP) and then they were asked to mentally simulate actions based on the type of cue. Hallucination-proneness was assessed using a self-report questionnaire [Cardiff Anomalous Perception Scale (CAPS)]. Our results indicated that atypical patterns of cerebral activation, particularly in the key areas of self-other distinction, were found in both groups at risk for auditory hallucinations (AHs and 22q11.2DS). More precisely, adolescents in the AH group presented decreased activations in the right middle occipital gyrus BA19, left cingulate gyrus BA31, and right precuneus BA31 for the 3PP > 1PP contrast. Adolescents in the 22q11.2DS group presented decreased activations in the right superior occipital gyrus BA19, left caudate tail and left precuneus BA7 for the 3PP > 1PP contrast. In comparison to the Control group, only the 22q11.2DS adolescents showed a decreased activation for other-related cues (prime other > prime self contrast) in areas of visual imagery, episodic memory and social cognition. This study characterizes the neural correlates of mental imagery for actions during adolescence, and suggests that a differential risk for hallucination-proneness (clinical vs. genetic) is associated to similar patterns of atypical activations in key areas sustaining self-other discrimination processes. These observations may provide relevant information for future research and prevention strategies with regards to hallucination-proneness during adolescence.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 96%

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Action simulation in hallucination-prone adolescents

Dahoun

Eliez

Chen

et al. 2013

Front. Hum. Neurosci.

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“…Our group has carried out two investigations examining the relationship between self-monitoring difficulties and schizotypy during adolescence (Debbané et al, 2008, 2009). In both studies, we observed a significant association between increased self-reported schizotypy and self-monitoring impairments, suggesting that metacognitive difficulties related to the self may underpin the early expression of risk for psychosis in adolescence.…”

Section: Mentalizing As a Moderator Of Psychosis Vulnerabilitymentioning

confidence: 99%

Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum

Debbané

Salaminios

Luyten

et al. 2016

Front. Hum. Neurosci.

135

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In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which insecure attachment may contribute to psychosis, we identify at least five neurobiological pathways linking attachment to risk for developing psychosis. Besides its well documented influence on the hypothalamic-pituary-adrenal (HPA) axis, insecure attachment may also contribute to neurodevelopmental risk through the dopaminergic and oxytonergic systems, as well as bear influence on neuroinflammation and oxidative stress responses. We further consider the neuroscientific and behavioral studies that underpin mentalization as a suite of processes potentially moderating the risk to transition to psychotic disorders. In particular, mentalization may help the individual compensate for endophenotypical impairments in the integration of sensory and metacognitive information. We propose a model where embodied mentalization would lie at the core of a protective, resilience response mitigating the adverse and potentially pathological influence of the neurodevelopmental cascade of risk for psychosis.

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“…Participants aged 18 years and older were assessed using the Structured Clinical Interview for DSM Disorders (SCID). Participants with 22q11DS underwent the Structured Interview of Prodromal Symptoms (SIPS) (McGlashan, 2001) to assess the full breath of prodromal signs of psychosis in this population (Debbané et al, 2008;Stoddard et al, 2010;Schneider et al, 2012). We followed the Criteria for Prodromal Syndromes (COPS 3.0) in identifying prodromal syndromes.…”

Section: Participantsmentioning

confidence: 99%

Resting-state networks in adolescents with 22q11.2 deletion syndrome: Associations with prodromal symptoms and executive functions

Debbané

Lazouret

Lagioia

et al. 2012

Schizophrenia Research

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Atypical functional connectivity in the maturing brains of 22q11.2 deletion syndrome (22q11DS) may contribute to the expression of early psychotic symptoms commonly reported by these youths. This study's objective was to examine functional connectivity in cerebral networks at rest (Resting-State Networks; RSNs) and their relationship to symptomatic and neuropsychological characteristics putting them at very high risk factor for developing psychosis. Twenty-seven adolescents with 22q11DS and 33 typically developing control adolescents matched for age, gender and handedness underwent an 8-minute resting state functional MRI session. RSNs identification procedure employed Independent Component Analysis (ICA). We tested for potential group differences in functional connectivity within-networks. Then, we examined relationships between network connectivity and symptomatic/neuropsychological characteristics in the 22q11DS group. A total of nine resting-state networks were identified. Between-group differences suggested both increased and decreased functional connectivity in the 22q11DS group, involving the default-mode, sensorimotor, visuo-spatial, and high level visual networks. Finally, atypical connectivity in the default-mode network, specifically within the left superior frontal gyrus region, correlated with prodromal symptom intensity and neuropsychological performances in the 22q11DS group. The results suggest that atypical functional connectivity may sustain both increased vulnerability to psychosis and characteristic cognitive impairments in 22q11DS.

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Source monitoring for actions in adolescents with 22q11.2 deletion syndrome (22q11DS)

Cited by 24 publications

References 46 publications

Action simulation in hallucination-prone adolescents

Action simulation in hallucination-prone adolescents

Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum

Resting-state networks in adolescents with 22q11.2 deletion syndrome: Associations with prodromal symptoms and executive functions

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