Sources, bioaccumulation, and toxicity mechanisms of cadmium in Chlamys farreri

Liu, Huan; Tian, Xiuhui; Jiang, Lisheng; Han, Dong; Hu, Shunxin; Cui, Yunxia; Jiang, Fang; Xu, Yingjiang; Li, Huanjun

doi:10.1016/j.jhazmat.2023.131395

Cited by 10 publications

(3 citation statements)

References 87 publications

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“…For instance, cadmium exposure elicited differential regulation of superoxide dismutases (SOD) and gluthatione-S-transferases (GST) (ZM: SOD2; QM SOD1, GST, GSTP1; for details, see Table 1 B and Table S5 ). This response was expected due to cadmium’s properties and its ability to indirectly cause oxidative stress [ 22 , 24 , 31 , 40 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

“…Of these, 88 exhibited a significant difference in protein abundance between exposed and control animals. In total, 60 For the detailed results of the ZM gill proteomics, the gel images were merged into a master gel displaying 1561 proteoforms. Of these, 88 exhibited a significant difference in protein abundance between exposed and control animals.…”

Section: General Overviewmentioning

confidence: 99%

“…Table S4: Gene Ontology Biological Process enrichment in zebra and quagga mussel gills after cadmium exposure. Table S5: Short Summary of protein functions extracts from online database annotations [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 …”

mentioning

confidence: 99%

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Cadmium Highlights Common and Specific Responses of Two Freshwater Sentinel Species, Dreissena polymorpha and Dreissena rostriformis bugensis

Bultelle,

Le Saux,

David

et al. 2024

Proteomes

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Zebra mussel (ZM), Dreissena polymorpha, commonly used as a sentinel species in freshwater biomonitoring, is now in competition for habitat with quagga mussel (QM), Dreissena rostriformis bugensis. This raises the question of the quagga mussel’s use in environmental survey. To better characterise QM response to stress compared with ZM, both species were exposed to cadmium (100 µg·L−1), a classic pollutant, for 7 days under controlled conditions. The gill proteomes were analysed using two-dimensional electrophoresis coupled with mass spectrometry. For ZM, 81 out of 88 proteoforms of variable abundance were identified using mass spectrometry, and for QM, 105 out of 134. Interestingly, the proteomic response amplitude varied drastically, with 5.6% of proteoforms of variable abundance (DAPs) in ZM versus 9.4% in QM. QM also exhibited greater cadmium accumulation. Only 12 common DAPs were observed. Several short proteoforms were detected, suggesting proteolysis. Functional analysis is consistent with the pleiotropic effects of the toxic metal ion cadmium, with alterations in sulphur and glutathione metabolisms, cellular calcium signalling, cytoskeletal dynamics, energy production, chaperone activation, and membrane events with numerous proteins involved in trafficking and endocytosis/exocytosis processes. Beyond common responses, the sister species display distinct reactions, with cellular response to stress being the main category involved in ZM as opposed to calcium and cytoskeleton alterations in QM. Moreover, QM exhibited greater evidence of proteolysis and cell death. Overall, these results suggest that QM has a weaker stress response capacity than ZM.

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