Sources, Occurrence, and Environmental Risk Assessment of Antibiotics and Antimicrobial-Resistant Bacteria in Aquatic Environments of Poland

Korzeniewska, Ewa; Harnisz, Monika

doi:10.1007/978-3-030-12139-6_9

Cited by 11 publications

(8 citation statements)

References 69 publications

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“…The pattern and consumption rate, excretion, and the efficacy of elimination by wastewater treatment processes, together with weather conditions, especially rainwater, usually influence the concentrations of the antibiotics detected in wastewater treatment plant influents and effluents (Osorio et al 2012 ). Certain antimicrobial agents, especially macrolides, sulfonamides, quinolones, and trimethoprim, persist in the aqueous environment and are among the most frequently detected substances in the environmental matrices due to their stability and because they are frequently prescribed in veterinary and human medicine (Wang and Wang 2016 ; Korzeniewska and Harnisz 2020 ). Considering their occurrence as demonstrated in various studies, the WWTP effluents containing high concentrations of these antibiotics are discharged into surface water, especially rivers, which subsequently become the main outlets of such antimicrobials into the rest of the natural aqueous environment.…”

Section: Antibiotics Classes Frequently Detected In Aqueous Environmentsmentioning

confidence: 99%

“…This group consists of a class of broad-spectrum antimicrobial compounds, which are the most frequently administered antimicrobials in all European countries similar to the rest of the world (Korzeniewska and Harnisz 2020 ). β-Lactams are structurally characterized by a β-lactam ring which is highly susceptible to hydrolysis by a variety of reagents, both biotic (enzymatic and biological degradation) and abiotic (chemical degradation) processes.…”

Section: Antibiotics Classes Frequently Detected In Aqueous Environmentsmentioning

confidence: 99%

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Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches

Mutuku

Gazdag

Melegh

2022

World J Microbiol Biotechnol

111

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Antimicrobial pharmaceuticals are classified as emergent micropollutants of concern, implying that even at low concentrations, long-term exposure to the environment can have significant eco-toxicological effects. There is a lack of a standardized regulatory framework governing the permissible antibiotic content for monitoring environmental water quality standards. Therefore, indiscriminate discharge of antimicrobials at potentially active concentrations into urban wastewater treatment facilities is rampant. Antimicrobials may exert selective pressure on bacteria, leading to resistance development and eventual health consequences. The emergence of clinically important multiple antibiotic-resistant bacteria in untreated hospital effluents and wastewater treatment plants (WWTPs) has been linked to the continuous exposure of bacteria to antimicrobials. The levels of environmental exposure to antibiotics and their correlation to the evolution and spread of resistant bacteria need to be elucidated to help in the formulation of mitigation measures. This review explores frequently detected antimicrobials in wastewater and gives a comprehensive coverage of bacterial resistance mechanisms to different antibiotic classes through the expression of a wide variety of antibiotic resistance genes either inherent and/or exchanged among bacteria or acquired from the reservoir of antibiotic resistance genes (ARGs) in wastewater systems. To complement the removal of antibiotics and ARGs from WWTPs, upscaling the implementation of prospective interventions such as vaccines, phage therapy, and natural compounds as alternatives to widespread antibiotic use provides a multifaceted approach to minimize the spread of antimicrobial resistance.

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Section: Antibiotics Classes Frequently Detected In Aqueous Environmentsmentioning

confidence: 99%

Section: Antibiotics Classes Frequently Detected In Aqueous Environmentsmentioning

confidence: 99%

Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches

Mutuku

Gazdag

Melegh

2022

World J Microbiol Biotechnol

111

View full text Add to dashboard Cite

show abstract

Section: Antibiotics Classes Frequently Detected In Aqueous Environmentsmentioning

confidence: 99%

Occurrence of Antibiotics and Bacterial Resistance Genes in Wastewater Resistance Mechanisms and Antimicrobial Resistance Control Approaches

Mutuku¹,

Gazdag²,

Melegh³

2022

Which Factors Contribute to Innovative Performance? A Case Study Applied to the Food and Beverage Industry

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Antimicrobial pharmaceuticals are classified as emergent micropollutants of concern, implying that even at low concentrations long-term exposure to the environment can have significant eco-toxicological effects. There is a lack of a standardized regulatory framework governing the permissible antibiotic content for monitoring environmental water quality standards. Therefore, indiscriminate discharge of antimicrobials at potentially active concentrations into urban wastewater treatment facilities is rampant. Antimicrobials may exert selective pressure on bacteria, leading to resistance development and eventual health consequences. The emergence of clinically Prime Archives in Immunology: 2 nd Edition 3 www.videleaf.com important multiple antibiotic-resistant bacteria (ARB) in untreated hospital effluents and wastewater treatment plants (WWTPs) has been linked to the continuous exposure of bacteria to antimicrobials. The levels of environmental exposure to antibiotics and their correlation to the evolution and spread of resistant bacteria need to be elucidated to help in the formulation of mitigation measures. This review explores frequently detected antimicrobials in wastewater and gives a comprehensive coverage of bacterial resistance mechanisms to different antibiotic classes through the expression of a wide variety of antibiotic resistance genes either inherent and/or exchanged among bacteria or acquired from the reservoir of antibiotic resistance genes (ARGs) in wastewater systems. To complement the removal of antibiotics and ARGs from WWTPs, upscaling the implementation of prospective interventions such as vaccines, phage therapy, and natural compounds as alternatives to widespread antibiotic use provides a multifaceted approach to minimize the spread of antimicrobial resistance.

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“…Amoxicillin is not highly persistent in the environment due to its specific chemical structure and the presence of a ring that is easily degraded by H + , OH -, Ca 2+ , Mg 2+ and Fe 2+ ions [15]. However, even trace amounts of drug transformation products (TPs) in the environment can promote the spread of antibiotic resistance [16]. The presence and spread of broad-spectrum betalactamases in the environment pose a particularly serious threat to public health around the world [17].…”

Section: Introductionmentioning

confidence: 99%

Metagenomic Analysis of the Long-Term Synergistic Effects of Antibiotics on the Anaerobic Digestion of Cattle Manure

et al. 2022

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The conversion of cattle manure into biogas in anaerobic digestion (AD) processes has been gaining attention in recent years. However, antibiotic consumption continues to increase worldwide, which is why antimicrobial concentrations can be expected to rise in cattle manure and in digestate. This study examined the long-term synergistic effects of antimicrobials on the anaerobic digestion of cattle manure. The prevalence of antibiotic resistance genes (ARGs) and changes in microbial biodiversity under exposure to the tested drugs was investigated using a metagenomic approach. Methane production was analyzed in lab-scale anaerobic bioreactors. Bacteroidetes, Firmicutes, and Actinobacteria were the most abundant bacteria in the samples. The domain Archaea was represented mainly by methanogenic genera Methanothrix and Methanosarcina and the order Methanomassiliicoccales. Exposure to antibiotics inhibited the growth and development of methanogenic microorganisms in the substrate. Antibiotics also influenced the abundance and prevalence of ARGs in samples. Seventeen types of ARGs were identified and classified. Genes encoding resistance to tetracyclines, macrolide–lincosamide–streptogramin antibiotics, and aminoglycosides, as well as multi-drug resistance genes, were most abundant. Antibiotics affected homoacetogenic bacteria and methanogens, and decreased the production of CH4. However, the antibiotic-induced decrease in CH4 production was minimized in the presence of highly drug-resistant microorganisms in AD bioreactors.

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Sources, Occurrence, and Environmental Risk Assessment of Antibiotics and Antimicrobial-Resistant Bacteria in Aquatic Environments of Poland

Cited by 11 publications

References 69 publications

Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches

Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches

Occurrence of Antibiotics and Bacterial Resistance Genes in Wastewater Resistance Mechanisms and Antimicrobial Resistance Control Approaches

Metagenomic Analysis of the Long-Term Synergistic Effects of Antibiotics on the Anaerobic Digestion of Cattle Manure

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