Case PresentationConsultation Request "Mr. B, a 36-year-old man with a history of Graves' disease and mood disorder is admitted to the inpatient psychiatric service on an emergency hold. The endocrinology service has recommended radioactive iodine (RAI) ablation of his thyroid gland to control severe Graves' disease, but the patient is refusing this procedure. Please assess for informed consent."
InformantsInformation was obtained from Mr. B, the inpatient psychiatric service, the endocrinology service, and a review of most of Mr. B's outpatient psychiatric and medical records.
History of Present IllnessPolice brought Mr. B to the emergency department after he was caught trespassing in a restricted area. He told the police officers that he had to go to this restricted area to punish those responsible for implanting satellite chips in his head, neck, and abdomen when he was 1 year old. On interview, Mr. B provided the same account. He denied any auditory or visual hallucinations or suicidal ideation. His mood was irritable, and he would not cooperate with an assessment of neurovegetative symptoms. Mr. B reported that he had not been taking his psychotropic medications or his methimazole for his Graves' disease. Because of evidence of psychiatric disorder, imminent harm to others, and perc e i v e d b e n e f i t o f i n p a t i e n t psychiatric treatment, Mr. B was placed on a 7-day hold.
Hospital CourseMr. B was quickly titrated to his former outpatient dose of ziprasidone (80 mg b.i.d.). Despite this treatment, he continued to have an irritable mood, impulsive and aggressive behavior, decreased need for sleep, and somatic and paranoid delusions. On multiple occasions, his disruptive and "dangerous" behavior resulted in the use of chemical and physical restraints. His cooperation with the treatment team was minimal. Mr. B's inpatient psychiatric hospitalization was further complicated by his medical problems. The psychiatric service consulted the internal medicine service to investigate malignant hypertension and the endocrinology service regarding Graves' disease. The endocrinology service was impressed with the severe stigmata of Mr. B's Graves' disease, which included visible goiter, bilateral tremor, and Graves' dermopathy. Mr. B's thyroid laboratory test results on admission were equally impressive, with his thyrotropin level undetectable and his T 4 level at 23.4 µg/dl. Given the failure of outpatient management with methimazole, the low likelihood of cure with methimazole with such a large gland, and the severity of the psychiatric and medical manifestations of Mr. B's hyperthyroidism, the endocrinologists recommended a definitive cure with RAI ablation. The endocrinologists explained their reasoning to Mr. B, but he refused the procedure. According to the endocrinology notes, his rationale for refusal was that he was "being held against [his] will." Efforts to contact Mr. B's family to obtain a surrogate decision maker were unsuccessful. The psychiatric intern subsequently told the patient and the endocr...