Sources of pathogens causing pleuropulmonary infections after lung cancer resection

Sok, Mihael

doi:10.1016/s1010-7940(02)00244-0

Cited by 44 publications

(30 citation statements)

References 12 publications

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“…One study reports that pulmonary infection may impact negatively on the survival of lung cancer patients [3]. A thorough review of the literature indicated that bronchial colonisation has been often evaluated in patients undergoing a cancer resection, as this population has a high risk of severe pulmonary infectious complications and mortality following thoracic surgery [6,7,[15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Bronchial colonisation in patients with lung cancer: a prospective study

et al. 2012

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Bronchial colonisation is frequently reported in patients with lung cancer, and has a potential impact on therapeutic management and prognosis. We aimed to prospectively define the prevalence and nature of bronchial colonisation in patients at the time of diagnosing lung cancer.210 consecutive patients with lung cancer underwent a flexible bronchoscopy for lung cancer. The type and frequency of bacterial, mycobacterial and fungal colonisation were analysed and correlated with the patients' and tumours' characteristics.Potential pathogens were found in 48.1% of samples: mainly the Gram-negative bacilli Escherichia coli (8.1%), Haemophilus influenzae (4.3%) and Enterobacter spp. (2.4%); Gram-positive cocci, Staphylococcus spp. (12.9%) and Streptococcus pneumoniae (3.3%); atypical mycobacteria (2.9%); Candida albicans (42.9%); and Aspergillus fumigatus (6.2%). Aged patients (p50.02) with chronic obstructive pulmonary disease (p50.008) were significantly more frequently colonised; however, tumour stage, atelectasis, bronchial stenosis and abnormalities of chest radiography were not associated with a higher rate of colonisation. Squamous cell carcinoma tended to be more frequently colonised than other histological subtypes. Airway colonisation was reported in almost half of patients presenting with lung cancer, mainly in fragile patients, and was significantly associated with worse survival (p50.005).Analysing colonisation status of patients at the time of diagnosis may help improve the management of lung cancer. @ERSpublications Characteristics and impact of bronchial colonisation in patients at the time of lung cancer diagnosis

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Section: Discussionmentioning

confidence: 99%

Bronchial colonisation in patients with lung cancer: a prospective study

et al. 2012

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“…Comparison with previous studies on PAC is difficult since the majority of data relates to patients with lung resection for cancer [22][23][24][25][26]. However, the majority of these studies on lung cancer demonstrate a significant correlation of PAC with postoperative lung infection as seen in this study on esophageal cancer [22,25,26].…”

Section: Discussionmentioning

confidence: 62%

Preoperative airway colonization prior to transthoracic esophagectomy predicts postoperative pulmonary complications

Bludau

Hölscher

Bollschweiler

et al. 2015

Langenbecks Arch Surg

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“…-If the empyema is healed, the surgical procedure for lung cancer can be planned as normal -Decortication is not always necessary -Interval between the empyema treatment and the operation: -no strict recommendations -no suffi cient data for comparison -Post-operative adjuvant therapy should be used if required of post-operative sputum samples (p<0.01) [45]. These data, although useful, are of little help for pre-operative selection.…”

Section: Intrathoracic Contaminationmentioning

confidence: 99%

Fit for surgery? Assessment of marginal lung cancer patients

Subotic

2009

breathe

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Educational aimsOutline the risks of surgery for lung cancer and chronic obstructive lung disease (COPD) patients.Define the risks of lung resection in patients with lung cancer and cardiac comorbidity.Describe complications with lung resection in the elderly.Examine the ideal operative procedure for lung resection.SummarySurgical treatment is still a treatment of choice for many stage I–IIIA lung cancer patients. Owing to modern methods of risk assessment, the option of surgery has now extended to patient groups that would have been rejected from surgery 10–15 yrs ago. Patients with COPD constitute the majority of such patients, followed by patients with associated cardiac comorbidity and elderly patients undergoing lung resection. In these patients, the risk of post-operative complications and death exists independently of the level of surgical skills and post-operative care. Similarly, patients undergoing lung resection after neoadjuvant treatment and previous pleural empyema, or patients requiring very extended resections, are exposed to an increased risk of operative morbidity and mortality. The possibility of unpredicted complications makes the pre-operative selection even more delicate. Each of these patient groups requires a specific, multidisciplinary approach that necessitates close collaboration between pulmonary physicians, thoracic oncologists and thoracic surgeons.

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Sources of pathogens causing pleuropulmonary infections after lung cancer resection

Abstract: Our results indicate that pathogens that cause pleuropulmonary infective complications are probably acquired postoperatively from the patient's oral cavity, pharynx and hypopharynx. Appropriate antibiotic prophylaxis is discussed.

Cited by 44 publications

References 12 publications

Bronchial colonisation in patients with lung cancer: a prospective study

Bronchial colonisation in patients with lung cancer: a prospective study

Preoperative airway colonization prior to transthoracic esophagectomy predicts postoperative pulmonary complications

Fit for surgery? Assessment of marginal lung cancer patients

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