Background: Available empirical evidence shows increasing rates of stoma surgeries (i.e., colostomy) among persons in sub-Saharan Africa, particularly Ghana. Compared to developed countries, the management of colostomy is considered more stressful due to the absence of a homecare management model after discharge from the hospital. Yet, there exist a paucity of evidence on the experiences, challenges and coping strategies of persons living with colostomy after being discharged, within a resource constrained setting such as Ghana. Aims: The experiences and challenges as well as coping strategies of colostomy patients were explored and described in this study. Methods: Using a descriptive phenomenological design, semi-structured face-to-face interviews were conducted with a purposive sample of 15 patients with colostomy. Colaizzi’s analytical framework and a deductive process was employed to thematically analyse the data. Results: Themes that characterised participants’ experiences and challenges with colostomy comprised: social stigmatisation, social isolation/withdrawal, sex-related challenges, psychological experiences and challenges, suicidal ideation, physiological experiences and challenges, dietary/eating challenges, difficulties caring for colostomy, skin disorders, cost of colostomy accessories, and work restrictions. Amidst these experiences and challenges, participants were shown to promote their resilience in the face of adversity through assets and resources: social support, spirituality and religion, lifestyle modifications, nutritional and pharmacological strategies, and improvised stoma accessories.Conclusion: Persons living with colostomy experience numerous challenges that threatens their health and wellbeing. Yet, they rely on assets and resources to remain resilient in the face of these challenges. Findings have implications for policy interventions on public education, expansion of health insurance scheme, stoma nurse recruitment and training, and patients’ resilience healthcare strategies of colostomy in Ghana.