Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage

Manning, Cameron; Stringer, Michael; Dickie, Ben; Clancy, Una; Hernández, Maria C. Valdés; Wiseman, Stewart; García, Daniela Jaime; Sakka, Eleni; Backes, Walter H.; Ingrisch, Michael; Chappell, Francesca M; Doubal, Fergus; Buckley, Craig; Parkes, Laura M.; Parker, Geoff J.M.; Marshall, Ian; Wardlaw, Joanna M.; Thrippleton, Michael J.

doi:10.1002/mrm.28833

Cited by 29 publications

(37 citation statements)

References 45 publications

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“…However, validation would be required to determine how representative such metrics are of the vascular surface area. In-silico methods are also a promising approach to evaluate the influence of different noise sources, acquisition, and analysis strategies at minimal cost ( Bernal et al, 2021 , Manning et al, 2021 ). While promising non-contrast based imaging MRI-based techniques, including diffusion-weighted arterial spin labelling, require further development, particularly to improve the limited SNR in white matter.…”

Section: Discussionmentioning

confidence: 99%

Tracer kinetic assessment of blood–brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors

Stringer

Heye

Armitage

et al. 2021

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

Tracer kinetic assessment of blood–brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors

Stringer

Heye

Armitage

et al. 2021

NeuroImage: Clinical

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“…A dynamic contrast-enhanced MRI (DCE-MRI) [ 63 ] has been employed for in-vivo quantification of the pathological passage of plasma through BBB [ 64 , 65 ]. Moreover, apart from the BBB leakage, the possibility of estimating the vascular permeability-surface area product (PS) and the plasma volume fraction (VP) in a given region of interest has also been described [ 66 , 67 ].…”

Section: Possible and Proved New Markers Of Blood–brain Barrier Leaka...mentioning

confidence: 99%

“…Moreover, apart from the BBB leakage, the possibility of estimating the vascular permeability-surface area product (PS) and the plasma volume fraction (VP) in a given region of interest has also been described [ 66 , 67 ]. The model suggested that PS increased with WMH severity, aging, and other vascular risk factors, and at the same time, a lower blood vP [ 65 ]. The most promising in-vivo demonstration is that BBB integrity is compromised in more severe WMH, even beyond visible lesions [ 63 ] (Insert Figure 1 ).…”

Section: Possible and Proved New Markers Of Blood–brain Barrier Leaka...mentioning

confidence: 99%

Small Vessel Disease: Ancient Description, Novel Biomarkers

Moretti

Caruso

2022

IJMS

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Small vessel disease (SVD) is one of the most frequent pathological conditions which lead to dementia. Biochemical and neuroimaging might help correctly identify the clinical diagnosis of this relevant brain disease. The microvascular alterations which underlie SVD have common origins, similar cognitive outcomes, and common vascular risk factors. Nevertheless, the arteriolosclerosis process, which underlines SVD development, is based on different mechanisms, not all completely understood, which start from a chronic hypoperfusion state and pass through a chronic brain inflammatory condition, inducing a significant endothelium activation and a consequent tissue remodeling action. In a recent review, we focused on the pathophysiology of SVD, which is complex, involving genetic conditions and different co-morbidities (i.e., diabetes, chronic hypoxia condition, and obesity). Currently, many points still remain unclear and discordant. In this paper, we wanted to focus on new biomarkers, which can be the expression of the endothelial dysfunction, or of the oxidative damage, which could be employed as markers of disease progression or for future targets of therapies. Therefore, we described the altered response to the endothelium-derived nitric oxide-vasodilators (ENOV), prostacyclin, C-reactive proteins, and endothelium-derived hyperpolarizing factors (EDHF). At the same time, due to the concomitant endothelial activation and chronic neuroinflammatory status, we described hypoxia-endothelial-related markers, such as HIF 1 alpha, VEGFR2, and neuroglobin, and MMPs. We also described blood–brain barrier disruption biomarkers and imaging techniques, which can also describe perivascular spaces enlargement and dysfunction. More studies should be necessary, in order to implement these results and give them a clinical benefit.

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“…The direct method, high resolution dynamic contrast enhancement/imaging (DCI or DCE), is to image the presence of fluid leaking past the BBB into the interstitium, either by direct or indirect means. DCE is a post gadolinium contrast infusion technique [35][36][37][38][39][40][41]. It utilizes fast image acquisition to sequentially measure the entrance of contrast into the field of view and it can determine a variety of physiologic parameters related to blood flow and perfusion [42].…”

Section: Yes Lowmentioning

confidence: 99%

Utilizing 3D Arterial Spin Labeling to Identify Cerebrovascular Leak and Glymphatic Obstruction in Neurodegenerative Disease

Joseph

2021

Diagnostics

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New approaches are required to successfully intervene therapeutically in neurodegenerative diseases. Addressing the earliest phases of disease, blood brain barrier (BBB) leak before the accumulation of misfolded proteins has significant potential for success. To do so, however, a reliable, noninvasive and economical test is required. There are two potential methods of identifying the BBB fluid leak that results in the accumulation of normally excluded substances which alter neuropil metabolism, protein synthesis and degradation with buildup of misfolded toxic proteins. The pros and cons of dynamic contrast imaging (DCI or DCE) and 3D TGSE PASL are discussed as potential early identifying methods. The results of prior publications of the 3D ASL technique and an overview of the associated physiologic challenges are discussed. Either method may serve well as reliable physiologic markers as novel therapeutic interventions directed at the vasculopathy of early neurodegenerative disease are developed. They may serve well in addressing other neurologic diseases associated with either vascular leak and/or reduced glymphatic flow.

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Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 29 publications

References 45 publications

Tracer kinetic assessment of blood–brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors

Tracer kinetic assessment of blood–brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors

Small Vessel Disease: Ancient Description, Novel Biomarkers

Utilizing 3D Arterial Spin Labeling to Identify Cerebrovascular Leak and Glymphatic Obstruction in Neurodegenerative Disease

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