Soursop leaves (Annona muricata L.) endophytic fungi anticancer activity against HeLa cells

Potential of Indonesian Herbal as an Anti-Cancer Therapy: A Systemic Review of in vitro Studies

“… Astuti Y, et al 22 2022 S3 Annona muricata (Soursop) Note: Ethanol extract Tawangmangu Widr cell Colorectal cancer MTT Assay Induces cell viability loss, morphological changes, membrane mitochondrial potential loss, and cell termination in the G0/G1 phase The IC50 value of soursop leaf ethanol extract against Widr cells ranges from 0.03124–0.5 μg/mL at a dosage range of 33.125–450 ug/mL Soursop leaf ethanol extract against Widr cancer cells has a high cytotoxic activity 11. Hasan AEZ, et al 31 2022 Q1 Annona muricata (Soursop) Note: Ethyl acetate extract endophytic mushroom of Soursop leaf Sukabumi, Cianjur, Garut HeLa cell Cervix cancer MTT Assay Inhibits cell proliferation All three endophytic mushroom extracts (Sir-CA1, Sir-G2, and Sir-SM2) showed IC values of <30 lg mL All three endophytic mushroom extracts (Sir-CA1, Sir-G2, and Sir-SM2) have cytotoxic effects against HeLa cancer cell 12. Nugraha AS, et al 11 2019 Q3 Annona muricata (Soursop) Note: Methanol extract; alkaloid fraction; bioactive compound of coclaurine, reticuline, argentinine, atherosperminine, xylopine Malang HL-60, A549, HepG2 cell Leukemia, lung, and liver cancer MTT Assay Inhibits cell proliferation The IC50 value of xylopine bioactive compound of Annona muricata root extract against cancer cells HL-60, A549, and HepG2 is between 20–80 μg/mL Xylopine bioactive compound of Annona muricata root extract has the highest cytotoxic effect among other compounds against HL-60, A549, and HepG2 cancer cell 13.…”

“…Soursop has the potential to be anti-cancer 14 , 15 , 17–19 , 31 because it contains various compounds such as flavonoids, AGEs , and alkaloids that have anticancer capabilities. AGEs have the ability to inhibit mitochondrial complex I which can inhibit the formation of adenosine triphosphate (ATP), resulting in a decrease in ATP in cancer cells so that it can inhibit proliferation and induce apoptosis of cancer cells.…”

“…When compared to its presence in soursop leaves, the phytochemical content of soursop fruit, which includes alkaloids, annonaceous acetogenin compounds (AGEs), and phenols, demonstrates that each phytochemical category has a smaller variance in the fruit. 17 Soursop has the potential to be anti-cancer 14,15,[17][18][19]31 because it contains various compounds such as flavonoids, AGEs, and alkaloids that have anticancer capabilities. AGEs have the ability to inhibit mitochondrial complex I which can inhibit the formation of adenosine triphosphate (ATP), resulting in a decrease in ATP in cancer cells so that it can inhibit proliferation and induce apoptosis of cancer cells.…”

Endophytic Colletotrichum (Sordariomycetes, Glomerellaceae) species associated with Citrus grandis cv. “Tomentosa” in China

“…Dai et al (2017) found that nine species of Taxus endophytic fungi could produce paclitaxel. Hasan et al (2022) found endophytic fungi, Penicillium crustosum from Annona muricata L. has anti-cancer activity against HeLa cells. Therefore, it is necessary to study the effects of the endophytic community associated with these traditional medicinal plants.…”

Acetogenins from Annona muricata as Antimicrobial Agents

“…ACGs are the most studied biological compounds because they are specific to the Annonaceae family. They can inhibit the mitochondria's complex I and NADH oxidase, causing cellular apoptosis [7,8]. In addition, ACGs can affect alternative targets in cells, with possible covalent interaction, such as their ability to inhibit metalloproteins, chelate calcium, and modulate the histone H3 phosphorylation.…”