“…Aging-associated destruction of joints and cartilage degradation in osteoarthritis is correlated with changes in extracellular matrix of articular cartilage, such as cartilage ECM stiffness, and in the levels and solubility profiles of matrix crosslinks, especially pentosidine, as well as reduced thickness of cartilage, proteolysis, advanced glycation and calcification (Eyre et al, 1988;Pokharna et al, 1995;Lotz and Loeser, 2012). Notably, rejuvenation has emerged as a promising therapeutic regenerative approach for improvement or restoration of the self-repair capacity of injured or aging tissue and organ systems (Leung et al, 2006;Nelson et al, 2008;Luria and Chu, 2014;Sarkar et al, 2020), which has been proposed as a conversion into an embryonic-like state recapitulating many events during embryogenesis, including the reactivation of embryonic signature genes, and cytoskeletal/ECM components, and lineage specification (Vortkamp et al, 1998;Jankowski et al, 2009;Luo et al, 2009;Adam et al, 2015;Caldwell and Wang, 2015;Hu et al, 2017;Ransom et al, 2018;Feng et al, 2019;Lin W. et al, 2019;Miao et al, 2019). Consistently, the process of cartilage repair has been considered as recapitulation of various events during developmental morphogenesis.…”